about
Crystal structure of a DNA polymerase sliding clamp from a Gram-positive bacterium.The replication initiation protein Sld2 regulates helicase assembly.Cdc45 protein-single-stranded DNA interaction is important for stalling the helicase during replication stress.Dbf4-Cdc7 phosphorylation of Mcm2 is required for cell growth.The Dbf4-Cdc7 kinase promotes Mcm2-7 ring opening to allow for single-stranded DNA extrusion and helicase assembly.Methods to study kinase regulation of the replication fork helicase.Eukaryotic Replicative Helicase Subunit Interaction with DNA and Its Role in DNA Replication.Tracking a molecular motor with a nanoscale optical encoder.An intact Mcm10 coiled-coil interaction surface is important for origin melting, helicase assembly and the recruitment of Pol-α to Mcm2-7DnaB helicase activity is modulated by DNA geometry and forceDpb11 protein helps control assembly of the Cdc45·Mcm2-7·GINS replication fork helicase.Enabling association of the GINS protein tetramer with the mini chromosome maintenance (Mcm)2-7 protein complex by phosphorylated Sld2 protein and single-stranded origin DNA.Conserved mechanism for coordinating replication fork helicase assembly with phosphorylation of the helicaseThe Replication Initiation Protein Sld3/Treslin Orchestrates the Assembly of the Replication Fork Helicase during S Phase.Mcm10 coordinates the timely assembly and activation of the replication fork helicase.A Positive Amplification Mechanism Involving a Kinase and Replication Initiation Factor Helps Assemble the Replication Fork Helicase.Origin DNA Melting-An Essential Process with Divergent Mechanisms.Dpb11 may function with RPA and DNA to initiate DNA replicationInsights into the Initiation of Eukaryotic DNA Replication.GINS and Sld3 compete with one another for Mcm2-7 and Cdc45 binding.The replication initiation protein Sld3/Treslin orchestrates the assembly of the replication fork helicase during S phase.Origin single-stranded DNA releases Sld3 protein from the Mcm2-7 complex, allowing the GINS tetramer to bind the Mcm2-7 complex.Origin single-stranded DNA releases Sld3 protein from the Mcm2-7 complex, allowing the GINS tetramer to bind the Mcm2-7 complex.Mcm subunits can assemble into two different active unwinding complexes.The essential C family DnaE polymerase is error-prone and efficient at lesion bypass.Methods to study how replication fork helicases unwind DNA.Conserved interactions in the Staphylococcus aureus DNA PolC chromosome replication machine.Analysis of a multicomponent thermostable DNA polymerase III replicase from an extreme thermophile.The Dbf4-Cdc7 kinase promotes Mcm2-7 ring opening to allow for single-stranded DNA extrusion and helicase assemblySynthesis of Extended Single-Molecule Optical Encoders
P50
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P50
name
Irina Bruck
@ast
Irina Bruck
@en
Irina Bruck
@es
Irina Bruck
@nl
type
label
Irina Bruck
@ast
Irina Bruck
@en
Irina Bruck
@es
Irina Bruck
@nl
prefLabel
Irina Bruck
@ast
Irina Bruck
@en
Irina Bruck
@es
Irina Bruck
@nl