Fatty acid synthase as a potential therapeutic target in cancer. - Wikidata - awgldk - TriplyDB

Fatty acid synthase as a potential therapeutic target in cancer.

Fatty acid synthase as a potential therapeutic target in cancer.

http://www.wikidata.org/entity/Q35401716

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Targeting cellular metabolism to improve cancer therapeutics Parasitic Mistletoes of the Genera Scurrula and Viscum: From Bench to Bedside Fatty acid oxidation and carnitine palmitoyltransferase I: emerging therapeutic targets in cancer A novel approach to the discovery of anti-tumor pharmaceuticals: searching for activators of liponecrosis Lipid metabolic reprogramming in cancer cells Progress toward overcoming hypoxia-induced resistance to solid tumor therapy Lipid biology of breast cancer A human fatty acid synthase inhibitor binds β-ketoacyl reductase in the keto-substrate site Recent evidence regarding triclosan and cancer risk High sensitivity of Giardia duodenalis to tetrahydrolipstatin (orlistat) in vitro De novo fatty acid biosynthesis contributes significantly to establishment of a bioenergetically favorable environment for vaccinia virus infection From obesity to cancer: a review on proposed mechanisms.Dissecting the Structural Elements for the Activation of β-Ketoacyl-(Acyl Carrier Protein) Reductase from Vibrio cholerae.Feasibility and antitumor efficacy in vivo, of simultaneously targeting glycolysis, glutaminolysis and fatty acid synthesis using lonidamine, 6-diazo-5-oxo-L-norleucine and orlistat in colon cancer.Increased phosphatidylethanolamine N-methyltransferase gene expression in non-small-cell lung cancer tissue predicts shorter patient survival.4-methylene-2-octyl-5-oxotetrahydrofuran-3-carboxylic acid (C75), an inhibitor of fatty-acid synthase, suppresses the mitochondrial fatty acid synthesis pathway and impairs mitochondrial function Alpha-mangostin inhibits intracellular fatty acid synthase and induces apoptosis in breast cancer cells.FASN Inhibition and Taxane Treatment Combine to Enhance Anti-tumor Efficacy in Diverse Xenograft Tumor Models through Disruption of Tubulin Palmitoylation and Microtubule Organization and FASN Inhibition-Mediated Effects on Oncogenic Signaling and G Novel nuclear localization of fatty acid synthase correlates with prostate cancer aggressiveness Involvement of de novo synthesized palmitate and mitochondrial EGFR in EGF induced mitochondrial fusion of cancer cells.The selective target of capsaicin on FASN expression and de novo fatty acid synthesis mediated through ROS generation triggers apoptosis in HepG2 cells.The contribution of RNA decay quantitative trait loci to inter-individual variation in steady-state gene expression levels.Chemical inhibition of acetyl-CoA carboxylase suppresses self-renewal growth of cancer stem cells.Screening of multiple myeloma by polyclonal rabbit anti-human plasmacytoma cell immunoglobulin.Effect of maternal exposure to endocrine disrupting chemicals on reproduction and mammary gland development in female Sprague-Dawley rats.Combining cross-metathesis and activity-based protein profiling: new β-lactone motifs for targeting serine hydrolases Modulation of tumor fatty acids, through overexpression or loss of thyroid hormone responsive protein spot 14 is associated with altered growth and metastasis.Myelopoietic efficacy of orlistat in murine hosts bearing T cell lymphoma: implication in macrophage differentiation and activation Metabolic features of clear-cell renal cell carcinoma: mechanisms and clinical implications Efficacy of massage therapy on pain and dysfunction in patients with neck pain: a systematic review and meta-analysis.New strategies in prostate cancer: targeting lipogenic pathways and the energy sensor AMPK Maf1 is a novel target of PTEN and PI3K signaling that negatively regulates oncogenesis and lipid metabolism Raman microspectroscopy of noncancerous and cancerous human breast tissues. Identification and phase transitions of linoleic and oleic acids by Raman low-temperature studies.Investigational cancer drugs targeting cell metabolism in clinical development.Colonic mucosal fatty acid synthase as an early biomarker for colorectal neoplasia: modulation by obesity and gender Inhibition of the mevalonate pathway affects epigenetic regulation in cancer cells.Reverse TCA cycle flux through isocitrate dehydrogenases 1 and 2 is required for lipogenesis in hypoxic melanoma cells.Nuclear envelope expansion is crucial for proper chromosomal segregation during a closed mitosis.Inhibition of de novo Palmitate Synthesis by Fatty Acid Synthase Induces Apoptosis in Tumor Cells by Remodeling Cell Membranes, Inhibiting Signaling Pathways, and Reprogramming Gene Expression.Dysregulation of fatty acid synthesis and glycolysis in non-Hodgkin lymphoma.

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P2860

Fatty acid synthase as a potential therapeutic target in cancer.

http://www.wikidata.org/entity/Q35401716

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2010 nî lūn-bûn

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2010 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2010 թվականի ապրիլին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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Fatty acid synthase as a potential therapeutic target in cancer.

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Fatty acid synthase as a potential therapeutic target in cancer.

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Fatty acid synthase as a potential therapeutic target in cancer.

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Fatty acid synthase as a potential therapeutic target in cancer.

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Future Oncology

P1476

Fatty acid synthase as a potential therapeutic target in cancer.

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P2093

Paul L Nguyen

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Richard Flavin

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Stephane Peluso

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P2860

Inhibition of fatty acid synthase (FAS) suppresses HER2/neu (erbB-2) oncogene overexpression in cancer cells

Selectivity of inhibitors of endocannabinoid biosynthesis evaluated by activity-based protein profiling

Crystal structure of the thioesterase domain of human fatty acid synthase inhibited by Orlistat

The crystal structure of a mammalian fatty acid synthase

Structural and functional organization of the animal fatty acid synthase

Structure and molecular organization of mammalian fatty acid synthase

The isopeptidase USP2a regulates the stability of fatty acid synthase in prostate cancer

Characterization of the inactivation of rat fatty acid synthase by C75: inhibition of partial reactions and protection by substrates

Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis

A fatty acid synthase blockade induces tumor cell-cycle arrest by down-regulating Skp2.

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10.2217/FON.10.11

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