Reverse TCA cycle flux through isocitrate dehydrogenases 1 and 2 is required for lipogenesis in hypoxic melanoma cells.
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Mitochondrial metabolic remodeling in response to genetic and environmental perturbationsHypoxia and metabolic adaptation of cancer cellsNovel therapeutic targets of tumor metabolismMetabolic rewiring in melanomaDetermination of phosphate-activated glutaminase activity and its kinetics in mouse tissues using metabolic mapping (quantitative enzyme histochemistry)Mitochondrial respiration--an important therapeutic target in melanomaIDH1 regulates phospholipid metabolism in developing astrocytesMetabolic engineering of Mortierella alpina for arachidonic acid production with glycerol as carbon sourceAnalysis and interpretation of transcriptomic data obtained from extended Warburg effect genes in patients with clear cell renal cell carcinoma.The histone demethylase KDM3A regulates the transcriptional program of the androgen receptor in prostate cancer cells.Cancer-associated isocitrate dehydrogenase 1 (IDH1) R132H mutation and d-2-hydroxyglutarate stimulate glutamine metabolism under hypoxia.Determination of glutamate dehydrogenase activity and its kinetics in mouse tissues using metabolic mapping (quantitative enzyme histochemistry)Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stressThe Metagenome of Utricularia gibba's Traps: Into the Microbial Input to a Carnivorous Plant.The Effect of Pericellular Oxygen Levels on Proteomic Profile and Lipogenesis in 3T3-L1 Differentiated Preadipocytes Cultured on Gas-Permeable Cultureware.Isocitrate dehydrogenase mutations in gliomasMetabolomic signature of brain cancer.Redox regulation of the epigenetic landscape in cancer: a role for metabolic reprogramming in remodeling the epigenomeTargeting metabolic flexibility by simultaneously inhibiting respiratory complex I and lactate generation retards melanoma progression.Pharmacological inhibition of nicotinamide phosphoribosyltransferase (NAMPT), an enzyme essential for NAD+ biosynthesis, in human cancer cells: metabolic basis and potential clinical implications.Pro-inflammatory Macrophages Sustain Pyruvate Oxidation through Pyruvate Dehydrogenase for the Synthesis of Itaconate and to Enable Cytokine Expression.The potential for isocitrate dehydrogenase mutations to produce 2-hydroxyglutarate depends on allele specificity and subcellular compartmentalization.Expanding the concepts and tools of metabolic engineering to elucidate cancer metabolism.What do we know about IDH1/2 mutations so far, and how do we use it?Cofactor balance by nicotinamide nucleotide transhydrogenase (NNT) coordinates reductive carboxylation and glucose catabolism in the tricarboxylic acid (TCA) cycleWhat a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer.Annexin A1 sustains tumor metabolism and cellular proliferation upon stable loss of HIF1A.Metabolomics Reveals that Aryl Hydrocarbon Receptor Activation by Environmental Chemicals Induces Systemic Metabolic Dysfunction in Mice.Cancer metabolism meets systems biology: Pyruvate kinase isoform PKM2 is a metabolic master regulator.Metabolic Engineering of Mortierella alpina for Enhanced Arachidonic Acid Production through the NADPH-Supplying StrategyInhibition of mitochondrial 2-oxoglutarate dehydrogenase impairs viability of cancer cells in a cell-specific metabolism-dependent manner.cMYC expression in infiltrating gliomas: associations with IDH1 mutations, clinicopathologic features and outcome.IDH1 deficiency attenuates gluconeogenesis in mouse liver by impairing amino acid utilization.The aspartate metabolism pathway is differentiable in human hepatocellular carcinoma: transcriptomics and (13) C-isotope based metabolomics.Precision medicine driven by cancer systems biology.Glutamine-fueled mitochondrial metabolism is decoupled from glycolysis in melanoma.Mitophagy or how to control the Jekyll and Hyde embedded in mitochondrial metabolism: implications for melanoma progression and drug resistance.Therapeutic strategies impacting cancer cell glutamine metabolism.The Pasteur's Dictum: Nitrogen Promotes Growth and Oxygen Reduces the Need for Sugar.A systems approach reveals distinct metabolic strategies among the NCI-60 cancer cell lines.
P2860
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P2860
Reverse TCA cycle flux through isocitrate dehydrogenases 1 and 2 is required for lipogenesis in hypoxic melanoma cells.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Reverse TCA cycle flux through ...... sis in hypoxic melanoma cells.
@ast
Reverse TCA cycle flux through ...... sis in hypoxic melanoma cells.
@en
type
label
Reverse TCA cycle flux through ...... sis in hypoxic melanoma cells.
@ast
Reverse TCA cycle flux through ...... sis in hypoxic melanoma cells.
@en
prefLabel
Reverse TCA cycle flux through ...... sis in hypoxic melanoma cells.
@ast
Reverse TCA cycle flux through ...... sis in hypoxic melanoma cells.
@en
P2093
P2860
P1476
Reverse TCA cycle flux through ...... sis in hypoxic melanoma cells.
@en
P2093
Andrei L Osterman
David A Scott
Fabian V Filipp
Jeffrey W Smith
Ze'ev A Ronai
P2860
P304
P356
10.1111/J.1755-148X.2012.00989.X
P577
2012-03-27T00:00:00Z