Targeted mutation of the talpid3 gene in zebrafish reveals its conserved requirement for ciliogenesis and Hedgehog signalling across the vertebrates.
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The CP110-interacting proteins Talpid3 and Cep290 play overlapping and distinct roles in cilia assemblyEndothelial cilia are essential for developmental vascular integrity in zebrafishp53 gene targeting by homologous recombination in fish ES cellsMutations in human homologue of chicken talpid3 gene (KIAA0586) cause a hybrid ciliopathy with overlapping features of Jeune and Joubert syndromesEfficient methods for targeted mutagenesis in zebrafish using zinc-finger nucleases: data from targeting of nine genes using CompoZr or CoDA ZFNs.The chicken left right organizer has nonmotile cilia which are lost in a stage-dependent manner in the talpid(3) ciliopathy.Positive and negative regulation of Gli activity by Kif7 in the zebrafish embryo.IFT46 plays an essential role in cilia developmentThe Ciliopathy Protein CC2D2A Associates with NINL and Functions in RAB8-MICAL3-Regulated Vesicle Trafficking.KIAA0586 is Mutated in Joubert SyndromeUtilizing the chicken as an animal model for human craniofacial ciliopathies.Chromosomal deletions and inversions mediated by TALENs and CRISPR/Cas in zebrafish.miR-219 regulates neural progenitors by dampening apical Par protein-dependent Hedgehog signalingTargeted inactivation and identification of targets of the Gli2a transcription factor in the zebrafishAn essential role for Grk2 in Hedgehog signalling downstream of Smoothened.Primary Cilia and Mammalian Hedgehog Signaling.TALPID3 controls centrosome and cell polarity and the human ortholog KIAA0586 is mutated in Joubert syndrome (JBTS23)Mutations in KIAA0586 Cause Lethal Ciliopathies Ranging from a Hydrolethalus Phenotype to Short-Rib Polydactyly Syndrome.Failure of centrosome migration causes a loss of motile cilia in talpid(3) mutants.The ciliopathy protein TALPID3/KIAA0586 acts upstream of Rab8 activation in zebrafish photoreceptor outer segment formation and maintenance.Gene replacement by zinc finger nucleases in medaka embryos.A distal centriolar protein network controls organelle maturation and asymmetry
P2860
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P2860
Targeted mutation of the talpid3 gene in zebrafish reveals its conserved requirement for ciliogenesis and Hedgehog signalling across the vertebrates.
description
2011 nî lūn-bûn
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2011 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
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name
Targeted mutation of the talpi ...... alling across the vertebrates.
@ast
Targeted mutation of the talpi ...... alling across the vertebrates.
@en
type
label
Targeted mutation of the talpi ...... alling across the vertebrates.
@ast
Targeted mutation of the talpi ...... alling across the vertebrates.
@en
prefLabel
Targeted mutation of the talpi ...... alling across the vertebrates.
@ast
Targeted mutation of the talpi ...... alling across the vertebrates.
@en
P2093
P2860
P356
P1433
P1476
Targeted mutation of the talpi ...... alling across the vertebrates.
@en
P2093
Ashley Shu Mei Ng
Freek van Eeden
Stone Elworthy
P2860
P304
P356
10.1242/DEV.070862
P407
P577
2011-11-01T00:00:00Z