The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun. - Wikidata - awgldk - TriplyDB

The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun.

The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun.

http://www.wikidata.org/entity/Q35458082

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SIRT3 deacetylates and activates OPA1 to regulate mitochondrial dynamics during stress Potential Modulation of Sirtuins by Oxidative Stress Epigenetic regulation in cardiac fibrosis Sirtuins in hematological aging and malignancy Interplay between sirtuins, MYC and hypoxia-inducible factor in cancer-associated metabolic reprogramming SIRTain regulators of premature senescence and accelerated aging Regulation of Akt signaling by sirtuins: its implication in cardiac hypertrophy and aging From sirtuin biology to human diseases: an update Sirtuins in epigenetic regulation Overexpression of SIRT6 in the hippocampal CA1 impairs the formation of long-term contextual fear memory The role of sirtuins in cardiac disease Targeting histone deacetylases: perspectives for epigenetic-based therapy in cardio-cerebrovascular disease Exome Analyses of Long QT Syndrome Reveal Candidate Pathogenic Mutations in Calmodulin-Interacting Genes Cytosolic dynamics of annexin A6 trigger feedback regulation of hypertrophy via atrial natriuretic peptide in cardiomyocytes Sirt6 deficiency results in progression of glomerular injury in the kidney Cardioprotective Effects of SIRT6 in a Mouse Model of Transverse Aortic Constriction-Induced Heart Failure.Sirtuins: guardians of mammalian healthspan.Heart failure with preserved ejection fraction: molecular pathways of the aging myocardium Role of NAD+ and mitochondrial sirtuins in cardiac and renal diseases A cardiac-enriched microRNA, miR-378, blocks cardiac hypertrophy by targeting Ras signaling.MDM2-mediated degradation of SIRT6 phosphorylated by AKT1 promotes tumorigenesis and trastuzumab resistance in breast cancer Epigenetic mechanisms in heart failure pathogenesis Deficiency of cardiomyocyte-specific microRNA-378 contributes to the development of cardiac fibrosis involving a transforming growth factor β (TGFβ1)-dependent paracrine mechanism.Activation of the protein deacetylase SIRT6 by long-chain fatty acids and widespread deacylation by mammalian sirtuins.SIRT6 promotes COX-2 expression and acts as an oncogene in skin cancer.Sirtuin 1 ablation in endothelial cells is associated with impaired angiogenesis and diastolic dysfunction.How the proteome packages the genome for cardiovascular development.Sirt3 is essential for apelin-induced angiogenesis in post-myocardial infarction of diabetes.Nutritionally-induced catch-up growth Posttranslational modification of Sirt6 activity by peroxynitrite.Maternal Hyperglycemia Directly and Rapidly Induces Cardiac Septal Overgrowth in Fetal Rats.Sirtuins, aging, and cardiovascular risks.Gene-Diet Interaction between SIRT6 and Soybean Intake for Different Levels of Pulse Wave Velocity.Rare Variants Association Analysis in Large-Scale Sequencing Studies at the Single Locus Level Enhanced insulin sensitivity in skeletal muscle and liver by physiological overexpression of SIRT6 SIRT6 deficiency culminates in low-turnover osteopenia.Protective effects of sirtuins in cardiovascular diseases: from bench to bedside When Anti-Aging Studies Meet Cancer Chemoprevention: Can Anti-Aging Agent Kill Two Birds with One Blow?SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2.SIRT3 Blocks Aging-Associated Tissue Fibrosis in Mice by Deacetylating and Activating Glycogen Synthase Kinase 3β.

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The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun.

http://www.wikidata.org/entity/Q35458082

description

2012 nî lūn-bûn

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2012 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2012 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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name

The sirtuin SIRT6 blocks IGF-A ...... ypertrophy by targeting c-Jun.

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The sirtuin SIRT6 blocks IGF-A ...... ypertrophy by targeting c-Jun.

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The sirtuin SIRT6 blocks IGF-A ...... ypertrophy by targeting c-Jun.

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The sirtuin SIRT6 blocks IGF-A ...... ypertrophy by targeting c-Jun.

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The sirtuin SIRT6 blocks IGF-A ...... ypertrophy by targeting c-Jun.

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The sirtuin SIRT6 blocks IGF-A ...... ypertrophy by targeting c-Jun.

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Nature Medicine

P1476

The sirtuin SIRT6 blocks IGF-A ...... ypertrophy by targeting c-Jun.

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P2093

Chu-Xia Deng

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John M Cunningham

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Lei Zhong

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Madhu Gupta

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Mahesh P Gupta

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Nagalingam R Sundaresan

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Prabhakaran Vasudevan

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Raul Mostoslavsky

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Sadhana Samant

http://www.w3.org/2001/XMLSchema#string

Valluvan Jeevanandam

http://www.w3.org/2001/XMLSchema#string

P2860

Heart Disease and Stroke Statistics--2010 Update: A Report From the American Heart Association

Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase

SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin

Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins

SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span

The deacetylase SIRT1 promotes membrane localization and activation of Akt and PDK1 during tumorigenesis and cardiac hypertrophy

Extending healthy life span--from yeast to humans

SIRT3 is a stress-responsive deacetylase in cardiomyocytes that protects cells from stress-mediated cell death by deacetylation of Ku70

Increased JNK, AP-1 and NF-kappa B DNA binding activities in isoproterenol-induced cardiac remodeling

Class II histone deacetylases act as signal-responsive repressors of cardiac hypertrophy

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1643-1650

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scholarly article

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10.1038/NM.2961

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11

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18

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David B. Lombard

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2012-10-21T00:00:00Z

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232533795

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23086477

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4401084

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