Ultrastructural and immunocytochemical evidence that an incompetent blood-brain barrier is related to the pathophysiology of cavernous malformations. - Wikidata - awgldk - TriplyDB

Ultrastructural and immunocytochemical evidence that an incompetent blood-brain barrier is related to the pathophysiology of cavernous malformations.

Ultrastructural and immunocytochemical evidence that an incompetent blood-brain barrier is related to the pathophysiology of cavernous malformations.

http://www.wikidata.org/entity/Q35463131

about

"You Shall Not Pass"-tight junctions of the blood brain barrier KRIT1 regulates the homeostasis of intracellular reactive oxygen species Krit 1 interactions with microtubules and membranes are regulated by Rap1 and integrin cytoplasmic domain associated protein-1 A two-hit mechanism causes cerebral cavernous malformations: complete inactivation of CCM1, CCM2 or CCM3 in affected endothelial cells The outlook for adults with epileptic seizure(s) associated with cerebral cavernous malformations or arteriovenous malformations Lack of CCM1 induces hypersprouting and impairs response to flow The Structure of the Ternary Complex of Krev Interaction Trapped 1 (KRIT1) Bound to Both the Rap1 GTPase and the Heart of Glass (HEG1) Cytoplasmic Tail Rho kinase as a target for cerebral vascular disorders Regulation of cardiovascular development and integrity by the heart of glass-cerebral cavernous malformation protein pathway KRIT-1/CCM1 is a Rap1 effector that regulates endothelial cell cell junctions Dynamic regulation of the cerebral cavernous malformation pathway controls vascular stability and growth Identification of the Kelch family protein Nd1-L as a novel molecular interactor of KRIT1 KLF4 is a key determinant in the development and progression of cerebral cavernous malformations.Rap1 and its effector KRIT1/CCM1 regulate beta-catenin signaling.Advanced magnetic resonance imaging of cerebral cavernous malformations: part I. High-field imaging of excised human lesions CCM3 signaling through sterile 20-like kinases plays an essential role during zebrafish cardiovascular development and cerebral cavernous malformations Cliniconeuropathologic correlations show astroglial albumin storage as a common factor in epileptogenic vascular lesions.CCM1-ICAP-1 complex controls β1 integrin-dependent endothelial contractility and fibronectin remodeling Dynamic contrast-enhanced MRI evaluation of cerebral cavernous malformations.Neurocysticercosis, familial cerebral cavernomas and intracranial calcifications: differential diagnosis for adequate management.A T1 hyperintense perilesional signal aids in the differentiation of a cavernous angioma from other hemorrhagic masses.Perilesional Hyperintensity on T1-Weighted Images in Intra-Axial Brain Masses other than Cavernous Malformations.Cerebral cavernous malformation: new molecular and clinical insights.Recent insights into cerebral cavernous malformations: a complex jigsaw puzzle under construction.Advanced magnetic resonance imaging of cerebral cavernous malformations: part II. Imaging of lesions in murine models.Cavernous angioma: a clinical study of 35 cases with review of the literature.Biology of vascular malformations of the brain.Control of cell adhesion dynamics by Rap1 signaling.Cerebral cavernous malformations proteins inhibit Rho kinase to stabilize vascular integrity.Recent insights into cerebral cavernous malformations: animal models of CCM and the human phenotype Mechanisms of vascular stability and the relationship to human disease Developmental timing of CCM2 loss influences cerebral cavernous malformations in mice.A novel mouse model of cerebral cavernous malformations based on the two-hit mutation hypothesis recapitulates the human disease.KRIT1 protein depletion modifies endothelial cell behavior via increased vascular endothelial growth factor (VEGF) signaling.The cerebral cavernous malformation signaling pathway promotes vascular integrity via Rho GTPases Seizure risk from cavernous or arteriovenous malformations: prospective population-based study.Conditional deletion of Ccm2 causes hemorrhage in the adult brain: a mouse model of human cerebral cavernous malformations.Dynamic permeability and quantitative susceptibility: related imaging biomarkers in cerebral cavernous malformations Increased number of white matter lesions in patients with familial cerebral cavernous malformations.Untreated clinical course of cerebral cavernous malformations: a prospective, population-based cohort study.

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P2860

Ultrastructural and immunocytochemical evidence that an incompetent blood-brain barrier is related to the pathophysiology of cavernous malformations.

http://www.wikidata.org/entity/Q35463131

description

2001 nî lūn-bûn

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2001 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

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2001 թվականի օգոստոսին հրատարակված գիտական հոդված

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2001年の論文

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2001年論文

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2001年論文

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2001年論文

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2001年論文

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Ultrastructural and immunocyto ...... gy of cavernous malformations.

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Ultrastructural and immunocyto ...... gy of cavernous malformations.

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Ultrastructural and immunocyto ...... gy of cavernous malformations.

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Ultrastructural and immunocyto ...... gy of cavernous malformations.

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Journal of Neurology, Neurosurgery and Psychiatry

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Ultrastructural and immunocyto ...... gy of cavernous malformations.

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Clatterbuck RE

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Crain BJ

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Eberhart CG

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Rigamonti D

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P2860

KRIT1 is mutated in hyperkeratotic cutaneous capillary-venous malformation associated with cerebral capillary malformation

Tight junctions of the blood-brain barrier

Truncating mutations in CCM1, encoding KRIT1, cause hereditary cavernous angiomas

Mutations in the gene encoding KRIT1, a Krev-1/rap1a binding protein, cause cerebral cavernous malformations (CCM1)

Blood-brain barrier biology and methodology.

Angiographically occult vascular malformations: a correlative study of features on magnetic resonance imaging and histological examination.

Correlation of magnetic resonance characteristics and histopathological type of angiographically occult vascular malformations

Ultrastructural comparison of capillary and cavernous hemangiomas of the orbit.

The MRI appearance of cavernous malformations (angiomas).

Mixed vascular malformations of the brain: clinical and pathogenetic considerations.

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188-192

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pathophysiology

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1737494

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