ErbB3 ablation impairs PI3K/Akt-dependent mammary tumorigenesis. - Wikidata - awgldk - TriplyDB

ErbB3 ablation impairs PI3K/Akt-dependent mammary tumorigenesis.

ErbB3 ablation impairs PI3K/Akt-dependent mammary tumorigenesis.

http://www.wikidata.org/entity/Q35479646

about

Regulation of ERBB3/HER3 signaling in cancer ERBB3-mediated regulation of Bergmann glia proliferation in cerebellar lamination.An Antibody That Locks HER3 in the Inactive Conformation Inhibits Tumor Growth Driven by HER2 or Neuregulin ERBB receptors: from oncogene discovery to basic science to mechanism-based cancer therapeutics.pH-responsive artemisinin derivatives and lipid nanoparticle formulations inhibit growth of breast cancer cells in vitro and induce down-regulation of HER family members.Profiling the tyrosine phosphoproteome of different mouse mammary tumour models reveals distinct, model-specific signalling networks and conserved oncogenic pathways.Efferocytosis produces a prometastatic landscape during postpartum mammary gland involution.The receptor tyrosine kinase ErbB3 maintains the balance between luminal and basal breast epithelium Protein-Trap Insertional Mutagenesis Uncovers New Genes Involved in Zebrafish Skin Development, Including a Neuregulin 2a-Based ErbB Signaling Pathway Required during Median Fin Fold Morphogenesis Shp2 signaling suppresses senescence in PyMT-induced mammary gland cancer in mice.Dynamical modeling of uncertain interaction-based genomic networks.Dual inhibition of Type I and Type III PI3 kinases increases tumor cell apoptosis in HER2+ breast cancers Loss of hepatocyte ERBB3 but not EGFR impairs hepatocarcinogenesis Decreased LRIG1 in fulvestrant-treated luminal breast cancer cells permits ErbB3 upregulation and increased growth.Inhibition of p85, the non-catalytic subunit of phosphatidylinositol 3-kinase, exerts potent antitumor activity in human breast cancer cells.Anti-HER3 domain 1 and 3 antibodies reduce tumor growth by hindering HER2/HER3 dimerization and AKT-induced MDM2, XIAP, and FoxO1 phosphorylation.HER3 is required for HER2-induced preneoplastic changes to the breast epithelium and tumor formation.Conditional loss of ErbB3 delays mammary gland hyperplasia induced by mutant PIK3CA without affecting mammary tumor latency, gene expression, or signaling.MerTK inhibition in tumor leukocytes decreases tumor growth and metastasis Effects of neuregulin-1 administration on neurogenesis in the adult mouse hippocampus, and characterization of immature neurons along the septotemporal axis.ErbB3 downregulation enhances luminal breast tumor response to antiestrogens.Combination of antibody that inhibits ligand-independent HER3 dimerization and a p110α inhibitor potently blocks PI3K signaling and growth of HER2+ breast cancers.Human breast cancer cells harboring a gatekeeper T798M mutation in HER2 overexpress EGFR ligands and are sensitive to dual inhibition of EGFR and HER2.Inhibition of the HER2 pathway by n-3 polyunsaturated fatty acids prevents breast cancer in fat-1 transgenic mice.EV20, a Novel Anti-ErbB-3 Humanized Antibody, Promotes ErbB-3 Down-Regulation and Inhibits Tumor Growth In Vivo.The promise of anti-ErbB3 monoclonals as new cancer therapeutics Hybrid cells derived from breast epithelial cell/breast cancer cell fusion events show a differential RAF-AKT crosstalk.The interplay of HER2/HER3/PI3K and EGFR/HER2/PLC-γ1 signalling in breast cancer cell migration and dissemination.The natural compound fucoidan from New Zealand Undaria pinnatifida synergizes with the ERBB inhibitor lapatinib enhancing melanoma growth inhibition Anti-Trop2 blockade enhances the therapeutic efficacy of ErbB3 inhibition in head and neck squamous cell carcinoma.miR-152 is involved in the proliferation and metastasis of ovarian cancer through repression of ERBB3.HER3 status by immunohistochemistry is correlated with poor prognosis in hormone receptor-negative breast cancer patients.IL-7 splicing variant IL-7δ5 induces EMT and metastasis of human breast cancer cell lines MCF-7 and BT-20 through activation of PI3K/Akt pathway.The ShcA SH2 domain engages a 14-3-3/PI3'K signaling complex and promotes breast cancer cell survival.Posttranscriptional upregulation of HER3 by HER2 mRNA induces trastuzumab resistance in breast cancer

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P2860

ErbB3 ablation impairs PI3K/Akt-dependent mammary tumorigenesis.

http://www.wikidata.org/entity/Q35479646

description

2011 nî lūn-bûn

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2011 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2011 թվականի ապրիլին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

ErbB3 ablation impairs PI3K/Akt-dependent mammary tumorigenesis.

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ErbB3 ablation impairs PI3K/Akt-dependent mammary tumorigenesis.

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type

label

ErbB3 ablation impairs PI3K/Akt-dependent mammary tumorigenesis.

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ErbB3 ablation impairs PI3K/Akt-dependent mammary tumorigenesis.

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prefLabel

ErbB3 ablation impairs PI3K/Akt-dependent mammary tumorigenesis.

@ast

ErbB3 ablation impairs PI3K/Akt-dependent mammary tumorigenesis.

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0008-5472.CAN-10-3775

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Cancer Research

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ErbB3 ablation impairs PI3K/Akt-dependent mammary tumorigenesis.

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Anindita Chakrabarty

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Cammie Rinehart

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Carlos L Arteaga

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Christian Young

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Ivan D Horak

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Jamie C Stanford

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Joan T Garrett

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Lee Greenberger

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Rebecca S Cook

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Violeta Sánchez

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P2860

An activated ErbB3/NRG1 autocrine loop supports in vivo proliferation in ovarian cancer cells

Isolation and characterization of ERBB3, a third member of the ERBB/epidermal growth factor receptor family: evidence for overexpression in a subset of human mammary tumors

AKT/PKB signaling: navigating downstream

The ErbB2/ErbB3 heterodimer functions as an oncogenic unit: ErbB2 requires ErbB3 to drive breast tumor cell proliferation

MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling.

Untangling the ErbB signalling network

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

High frequency of mutations of the PIK3CA gene in human cancers

Cooperative signaling of ErbB3 and ErbB2 in neoplastic transformation and human mammary carcinomas

Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease.

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3941-3951

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10.1158/0008-5472.CAN-10-3775

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11

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51041471

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