An important role for Akt3 in platelet activation and thrombosis
about
Platelet signaling: a complex interplay between inhibitory and activatory networksPlatelet signalingA directional switch of integrin signalling and a new anti-thrombotic strategy.Racial differences in human platelet PAR4 reactivity reflect expression of PCTP and miR-376cNeutrophil AKT2 regulates heterotypic cell-cell interactions during vascular inflammationCalcium mobilization and protein kinase C activation downstream of protease activated receptor 4 (PAR4) is negatively regulated by PAR3 in mouse plateletsGq-mediated Akt translocation to the membrane: a novel PIP3-independent mechanism in platelets.A critical role for the transient receptor potential channel type 6 in human platelet activationPentamethylquercetin (PMQ) reduces thrombus formation by inhibiting platelet functionPlatelet-neutrophil interactions under thromboinflammatory conditionsThe Akt inhibitor, triciribine, ameliorates chronic hypoxia-induced vascular pruning and TGFβ-induced pulmonary fibrosis.SDF-1α/CXCR4 Signaling in Lipid Rafts Induces Platelet Aggregation via PI3 Kinase-Dependent Akt Phosphorylation.Engagement of platelet toll-like receptor 9 by novel endogenous ligands promotes platelet hyperreactivity and thrombosis.Suppressive effect of exogenous carbon monoxide on endotoxin-stimulated platelet over-activation via the glycoprotein-mediated PI3K-Akt-GSK3β pathwayThe Akt1 isoform is required for optimal IFN-β transcription through direct phosphorylation of β-catenin.LIM kinase-1 selectively promotes glycoprotein Ib-IX-mediated TXA2 synthesis, platelet activation, and thrombosis.ARQ 092, an orally-available, selective AKT inhibitor, attenuates neutrophil-platelet interactions in sickle cell disease.Tyrosine kinase inhibitors as potential drugs for B-cell lymphoid malignancies and autoimmune disorders.BCR signaling in chronic lymphocytic leukemia and related inhibitors currently in clinical studies.Harnessing the platelet signaling network to produce an optimal hemostatic response.The serum- & glucocorticoid-inducible kinase in the regulation of platelet function.New Concepts and Mechanisms of Platelet Activation Signaling.Ser/Thr protein kinase Bβ-NADPH oxidase 2 signaling in thromboinflammation.Association of Factor V Secretion with Protein Kinase B Signaling in Platelets from Horses with Atypical Equine Thrombasthenia.Dual regulation of glycogen synthase kinase 3 (GSK3)α/β by protein kinase C (PKC)α and Akt promotes thrombin-mediated integrin αIIbβ3 activation and granule secretion in platelets.The role of Rac1 in glycoprotein Ib-IX-mediated signal transduction and integrin activation.Akt and mitogen-activated protein kinase enhance C-type lectin-like receptor 2-mediated platelet activation by inhibition of glycogen synthase kinase 3α/β.Copy number analysis of the murine platelet proteome spanning the complete abundance range.ADP-stimulated activation of Akt during integrin outside-in signaling promotes platelet spreading by inhibiting glycogen synthase kinase-3β.The small molecule MERTK inhibitor UNC2025 decreases platelet activation and prevents thrombosis.Pharmacological inhibition of S6K1 facilitates platelet activation by enhancing Akt phosphorylation.Antiplatelet activity of chrysin via inhibiting platelet αIIbβ3-mediated signaling pathway.PDK1 selectively phosphorylates Thr(308) on Akt and contributes to human platelet functional responses.Enhanced platelet activity and thrombosis in a murine model of type I diabetes are partially insulin-like growth factor 1-dependent and phosphoinositide 3-kinase-dependent.The histone deacetylase sirtuin 2 is a new player in the regulation of platelet function.GAS6/TAM Pathway Signaling in Hemostasis and Thrombosis.
P2860
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P2860
An important role for Akt3 in platelet activation and thrombosis
description
2011 nî lūn-bûn
@nan
2011 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
An important role for Akt3 in platelet activation and thrombosis
@ast
An important role for Akt3 in platelet activation and thrombosis
@en
type
label
An important role for Akt3 in platelet activation and thrombosis
@ast
An important role for Akt3 in platelet activation and thrombosis
@en
prefLabel
An important role for Akt3 in platelet activation and thrombosis
@ast
An important role for Akt3 in platelet activation and thrombosis
@en
P2093
P2860
P1433
P1476
An important role for Akt3 in platelet activation and thrombosis
@en
P2093
Aleksandra Stojanovic-Terpo
Kelly A O'Brien
Nissim Hay
Xiaoping Du
P2860
P304
P356
10.1182/BLOOD-2010-12-323204
P407
P577
2011-08-05T00:00:00Z