Hepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance. - Wikidata - awgldk - TriplyDB

Hepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance.

Hepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance.

http://www.wikidata.org/entity/Q35484801

about

Novel nervous and multi-system regenerative therapeutic strategies for diabetes mellitus with mTOR Hyperglycemic Stress and Carbon Stress in Diabetic Glucotoxicity Histone Deacetylases and Cardiometabolic Diseases FoxO Transcription Factors and Regenerative Pathways in Diabetes Mellitus Sirtuin 1 and sirtuin 3: physiological modulators of metabolism Sirtuins as regulators of metabolism and healthspan Cutting through the complexities of mTOR for the treatment of stroke Leptin's role in lipodystrophic and nonlipodystrophic insulin-resistant and diabetic individuals Targeting disease through novel pathways of apoptosis and autophagy Metabolism, longevity and epigenetics Energy metabolism in the liver Shedding new light on neurodegenerative diseases through the mammalian target of rapamycin Redox regulation of SIRT1 in inflammation and cellular senescence Pancreas-Specific Sirt1-Deficiency in Mice Compromises Beta-Cell Function without Development of Hyperglycemia New Insights for Oxidative Stress and Diabetes Mellitus ATGL Promotes Autophagy/Lipophagy via SIRT1 to Control Hepatic Lipid Droplet Catabolism.Renal tubular Sirt1 attenuates diabetic albuminuria by epigenetically suppressing Claudin-1 overexpression in podocytes Associations among Metabolism, Circadian Rhythm and Age-Associated Diseases Erythropoietin signaling: a novel regulator of white adipose tissue inflammation during diet-induced obesity.mTORC2 in the center of cancer metabolic reprogramming Mechanistic target of rapamycin complex 2 protects the heart from ischemic damage Liver clock protein BMAL1 promotes de novo lipogenesis through insulin-mTORC2-AKT signaling The Role of SIRT1 in Diabetic Kidney Disease.PRAS40 is an integral regulatory component of erythropoietin mTOR signaling and cytoprotection Revealing the complexity of a monogenic disease: rett syndrome exome sequencing SIRT1 deacetylates TopBP1 and modulates intra-S-phase checkpoint and DNA replication origin firing Butyrate-producing probiotics reduce nonalcoholic fatty liver disease progression in rats: new insight into the probiotics for the gut-liver axis.SRT1720 induces lysosomal-dependent cell death of breast cancer cells.ATGL-catalyzed lipolysis regulates SIRT1 to control PGC-1α/PPAR-α signaling Inflammatory stimuli induce inhibitory S-nitrosylation of the deacetylase SIRT1 to increase acetylation and activation of p53 and p65 Restriction on an energy-dense diet improves markers of metabolic health and cellular aging in mice through decreasing hepatic mTOR activity Ursolic acid inhibits leucine-stimulated mTORC1 signaling by suppressing mTOR localization to lysosome Overexpression of SIRT1 in rat skeletal muscle does not alter glucose induced insulin resistance MicroRNA-221 inhibits autophagy and promotes heart failure by modulating the p27/CDK2/mTOR axis.Hepatic deletion of SIRT1 decreases hepatocyte nuclear factor 1α/farnesoid X receptor signaling and induces formation of cholesterol gallstones in mice.SIRT1 Disruption in Human Fetal Hepatocytes Leads to Increased Accumulation of Glucose and Lipids.Nicotinamide N-methyltransferase regulates hepatic nutrient metabolism through Sirt1 protein stabilization.dSir2 deficiency in the fatbody, but not muscles, affects systemic insulin signaling, fat mobilization and starvation survival in flies Maternal High-Fat Feeding Increases Placental Lipoprotein Lipase Activity by Reducing SIRT1 Expression in Mice.Myeloid-specific SIRT1 Deletion Aggravates Hepatic Inflammation and Steatosis in High-fat Diet-fed Mice

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P2860

Hepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance.

http://www.wikidata.org/entity/Q35484801

description

2011 nî lūn-bûn

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2011 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

Hepatic Sirt1 deficiency in mi ...... amage, and insulin resistance.

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Hepatic Sirt1 deficiency in mi ...... amage, and insulin resistance.

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type

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Hepatic Sirt1 deficiency in mi ...... amage, and insulin resistance.

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Hepatic Sirt1 deficiency in mi ...... amage, and insulin resistance.

@en

prefLabel

Hepatic Sirt1 deficiency in mi ...... amage, and insulin resistance.

@ast

Hepatic Sirt1 deficiency in mi ...... amage, and insulin resistance.

@en

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Journal of Clinical Investigation

P1476

Hepatic Sirt1 deficiency in mi ...... amage, and insulin resistance.

@en

P2093

Chu-Xia Deng

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Cuiying Xiao

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Hyun-Seok Kim

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Oksana Gavrilova

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Rui-Hong Wang

http://www.w3.org/2001/XMLSchema#string

Xiaoling Xu

http://www.w3.org/2001/XMLSchema#string

P2860

Insulin signalling and the regulation of glucose and lipid metabolism

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation

A requirement for breast-cancer-associated gene 1 (BRCA1) in the spindle checkpoint

SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress

A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange

Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity

Biochemistry and molecular cell biology of diabetic complications

Nonalcoholic fatty liver disease: a feature of the metabolic syndrome

Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1

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4477-4490

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10.1172/JCI46243

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11

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121

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21965330

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3204833

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