Hepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance.
about
Novel nervous and multi-system regenerative therapeutic strategies for diabetes mellitus with mTORHyperglycemic Stress and Carbon Stress in Diabetic GlucotoxicityHistone Deacetylases and Cardiometabolic DiseasesFoxO Transcription Factors and Regenerative Pathways in Diabetes MellitusSirtuin 1 and sirtuin 3: physiological modulators of metabolismSirtuins as regulators of metabolism and healthspanCutting through the complexities of mTOR for the treatment of strokeLeptin's role in lipodystrophic and nonlipodystrophic insulin-resistant and diabetic individualsTargeting disease through novel pathways of apoptosis and autophagyMetabolism, longevity and epigeneticsEnergy metabolism in the liverShedding new light on neurodegenerative diseases through the mammalian target of rapamycinRedox regulation of SIRT1 in inflammation and cellular senescencePancreas-Specific Sirt1-Deficiency in Mice Compromises Beta-Cell Function without Development of HyperglycemiaNew Insights for Oxidative Stress and Diabetes MellitusATGL Promotes Autophagy/Lipophagy via SIRT1 to Control Hepatic Lipid Droplet Catabolism.Renal tubular Sirt1 attenuates diabetic albuminuria by epigenetically suppressing Claudin-1 overexpression in podocytesAssociations among Metabolism, Circadian Rhythm and Age-Associated DiseasesErythropoietin signaling: a novel regulator of white adipose tissue inflammation during diet-induced obesity.mTORC2 in the center of cancer metabolic reprogrammingMechanistic target of rapamycin complex 2 protects the heart from ischemic damageLiver clock protein BMAL1 promotes de novo lipogenesis through insulin-mTORC2-AKT signalingThe Role of SIRT1 in Diabetic Kidney Disease.PRAS40 is an integral regulatory component of erythropoietin mTOR signaling and cytoprotectionRevealing the complexity of a monogenic disease: rett syndrome exome sequencingSIRT1 deacetylates TopBP1 and modulates intra-S-phase checkpoint and DNA replication origin firingButyrate-producing probiotics reduce nonalcoholic fatty liver disease progression in rats: new insight into the probiotics for the gut-liver axis.SRT1720 induces lysosomal-dependent cell death of breast cancer cells.ATGL-catalyzed lipolysis regulates SIRT1 to control PGC-1α/PPAR-α signalingInflammatory stimuli induce inhibitory S-nitrosylation of the deacetylase SIRT1 to increase acetylation and activation of p53 and p65Restriction on an energy-dense diet improves markers of metabolic health and cellular aging in mice through decreasing hepatic mTOR activityUrsolic acid inhibits leucine-stimulated mTORC1 signaling by suppressing mTOR localization to lysosomeOverexpression of SIRT1 in rat skeletal muscle does not alter glucose induced insulin resistanceMicroRNA-221 inhibits autophagy and promotes heart failure by modulating the p27/CDK2/mTOR axis.Hepatic deletion of SIRT1 decreases hepatocyte nuclear factor 1α/farnesoid X receptor signaling and induces formation of cholesterol gallstones in mice.SIRT1 Disruption in Human Fetal Hepatocytes Leads to Increased Accumulation of Glucose and Lipids.Nicotinamide N-methyltransferase regulates hepatic nutrient metabolism through Sirt1 protein stabilization.dSir2 deficiency in the fatbody, but not muscles, affects systemic insulin signaling, fat mobilization and starvation survival in fliesMaternal High-Fat Feeding Increases Placental Lipoprotein Lipase Activity by Reducing SIRT1 Expression in Mice.Myeloid-specific SIRT1 Deletion Aggravates Hepatic Inflammation and Steatosis in High-fat Diet-fed Mice
P2860
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P2860
Hepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance.
description
2011 nî lūn-bûn
@nan
2011 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Hepatic Sirt1 deficiency in mi ...... amage, and insulin resistance.
@ast
Hepatic Sirt1 deficiency in mi ...... amage, and insulin resistance.
@en
type
label
Hepatic Sirt1 deficiency in mi ...... amage, and insulin resistance.
@ast
Hepatic Sirt1 deficiency in mi ...... amage, and insulin resistance.
@en
prefLabel
Hepatic Sirt1 deficiency in mi ...... amage, and insulin resistance.
@ast
Hepatic Sirt1 deficiency in mi ...... amage, and insulin resistance.
@en
P2093
P2860
P356
P1476
Hepatic Sirt1 deficiency in mi ...... amage, and insulin resistance.
@en
P2093
Chu-Xia Deng
Cuiying Xiao
Hyun-Seok Kim
Oksana Gavrilova
Rui-Hong Wang
Xiaoling Xu
P2860
P304
P356
10.1172/JCI46243
P407
P577
2011-10-03T00:00:00Z