Molecular dynamics simulations of the Cx26 hemichannel: evaluation of structural models with Brownian dynamics.
about
Diseases associated with leaky hemichannelsConnexin hemichannel and pannexin channel electrophysiology: how do they differ?Motifs in the permeation pathway of connexin channels mediate voltage and Ca (2+) sensingKeratitis-ichthyosis-deafness syndrome-associated Cx26 mutants produce nonfunctional gap junctions but hyperactive hemichannels when co-expressed with wild type Cx43.Gating of Connexin Channels by transjunctional-voltage: Conformations and models of open and closed states.Voltage regulation of connexin channel conductance.Tryptophan Scanning Reveals Dense Packing of Connexin Transmembrane Domains in Gap Junction Channels Composed of Connexin32Molecular dynamics simulations of the Cx26 hemichannel: insights into voltage-dependent loop-gatingVoltage-dependent conformational changes in connexin channelsConnexinopathies: a structural and functional glimpseCritical role of the first transmembrane domain of Cx26 in regulating oligomerization and functionAccessing gap-junction channel structure-function relationships through molecular modeling and simulationsComputational Studies of Molecular Permeation through Connexin26 Channels.Voltage-dependent gating of the Cx32*43E1 hemichannel: conformational changes at the channel entrances.Functional requirement for a highly conserved charged residue at position 75 in the gap junction protein connexin 32.Properties of two cataract-associated mutations located in the NH2 terminus of connexin 46.Insights on the mechanisms of Ca(2+) regulation of connexin26 hemichannels revealed by human pathogenic mutations (D50N/Y).Exploring the Membrane Potential of Simple Dual-Membrane Systems as Models for Gap-Junction Channels.The N-terminal half of the connexin protein contains the core elements of the pore and voltage gates.The carboxyl terminal residues 220-283 are not required for voltage gating of a chimeric connexin32 hemichannel.Mechanism of gating by calcium in connexin hemichannelsConnexin channel modulators and their mechanisms of action.Extracellular domains play different roles in gap junction formation and docking compatibility.Structure and closure of connexin gap junction channels.Role of gamma carboxylated Glu47 in connexin 26 hemichannel regulation by extracellular Ca²⁺: insight from a local quantum chemistry study.Specificity of the connexin W3/4 locus for functional gap junction formation.Determinants of Cx43 Channel Gating and Permeation: The Amino TerminusA structural and functional comparison of gap junction channels composed of connexins and innexinsGap junction structure: unraveled, but not fully revealed.The 3.5 ångström X-ray structure of the human connexin26 gap junction channel is unlikely that of a fully open channel.Structural studies of N-terminal mutants of connexin 32 using (1)H NMR spectroscopy.Characterization of a novel water pocket inside the human Cx26 hemichannel structure.Modulation of Asymmetric Flux in Heterotypic Gap Junctions by Pore Shape, Particle Size and Charge.On Biophysical Properties and Sensitivity to Gap Junction Blockers of Connexin 39 Hemichannels Expressed in HeLa Cells.Structural studies of N-terminal mutants of Connexin 26 and Connexin 32 using (1)H NMR spectroscopy.Charged Residues at the First Transmembrane Region Contribute to the Voltage Dependence of the Slow Gate of Connexins.Role of amino terminus in voltage gating and junctional rectification of Shaking B innexins.Structure of an innexin gap junction channel and cryo-EM sample preparation.Gap-junctional channel and hemichannel activity of two recently identified connexin 26 mutants associated with deafness.The syndromic deafness mutation G12R impairs fast and slow gating in Cx26 hemichannels.
P2860
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P2860
Molecular dynamics simulations of the Cx26 hemichannel: evaluation of structural models with Brownian dynamics.
description
2011 nî lūn-bûn
@nan
2011 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Molecular dynamics simulations ...... models with Brownian dynamics.
@ast
Molecular dynamics simulations ...... models with Brownian dynamics.
@en
type
label
Molecular dynamics simulations ...... models with Brownian dynamics.
@ast
Molecular dynamics simulations ...... models with Brownian dynamics.
@en
prefLabel
Molecular dynamics simulations ...... models with Brownian dynamics.
@ast
Molecular dynamics simulations ...... models with Brownian dynamics.
@en
P2093
P2860
P356
P1476
Molecular dynamics simulations ...... models with Brownian dynamics.
@en
P2093
Andrew L Harris
Angelo Rossi
Taekyung Kwon
Thaddeus A Bargiello
P2860
P304
P356
10.1085/JGP.201110679
P577
2011-10-17T00:00:00Z