Genotype-dependent sensitivity of uveal melanoma cell lines to inhibition of B-Raf, MEK, and Akt kinases: rationale for personalized therapy.
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Culturing Uveal Melanoma CellsWhole-genome sequencing reveals complex mechanisms of intrinsic resistance to BRAF inhibition.Study design and rationale for a randomised, placebo-controlled, double-blind study to assess the efficacy of selumetinib (AZD6244; ARRY-142886) in combination with dacarbazine in patients with metastatic uveal melanoma (SUMIT).The genetics of uveal melanoma: an emerging framework for targeted therapyDriver mutations in melanoma: lessons learned from bench-to-bedside studiesResistance to vemurafenib resulting from a novel mutation in the BRAFV600E kinase domain.Translational models of ocular disease.miR-137 Targets p160 Steroid Receptor Coactivators SRC1, SRC2, and SRC3 and Inhibits Cell Proliferation.Prostate cancer-associated mutations in speckle-type POZ protein (SPOP) regulate steroid receptor coactivator 3 protein turnover.Patient survival in uveal melanoma is not affected by oncogenic mutations in GNAQ and GNA11Sorafenib in metastatic uveal melanoma: efficacy, toxicity and health-related quality of life in a multicentre phase II study.Systemic treatment of metastatic uveal melanoma: review of literature and future perspectivesPrecision medicine driven by cancer systems biology.Selumetinib (AZD6244; ARRY-142886) in the treatment of metastatic melanoma.Insights into melanoma: targeting the mTOR pathway for therapeutics.Towards combinatorial targeted therapy in melanoma: from pre-clinical evidence to clinical application (review).Primary melanocytic tumors of the central nervous system: a review with focus on molecular aspects.Uveal Melanoma Cell Lines: Where do they come from? (An American Ophthalmological Society Thesis).Update on Metastatic Uveal Melanoma: Progress and Challenges.Establishment of novel cell lines recapitulating the genetic landscape of uveal melanoma and preclinical validation of mTOR as a therapeutic target.Natural withanolide withaferin A induces apoptosis in uveal melanoma cells by suppression of Akt and c-MET activation.Mutations in g protein encoding genes and chromosomal alterations in primary leptomeningeal melanocytic neoplasms.Histologic and immunohistochemical predictors of clinical behavior for feline diffuse iris melanoma.ICG-001 Exerts Potent Anticancer Activity Against Uveal Melanoma Cells.
P2860
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P2860
Genotype-dependent sensitivity of uveal melanoma cell lines to inhibition of B-Raf, MEK, and Akt kinases: rationale for personalized therapy.
description
2011 nî lūn-bûn
@nan
2011 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Genotype-dependent sensitivity ...... nale for personalized therapy.
@ast
Genotype-dependent sensitivity ...... nale for personalized therapy.
@en
type
label
Genotype-dependent sensitivity ...... nale for personalized therapy.
@ast
Genotype-dependent sensitivity ...... nale for personalized therapy.
@en
prefLabel
Genotype-dependent sensitivity ...... nale for personalized therapy.
@ast
Genotype-dependent sensitivity ...... nale for personalized therapy.
@en
P2093
P2860
P356
P1476
Genotype-dependent sensitivity ...... nale for personalized therapy.
@en
P2093
Aline I Riechardt
Nicholas Mitsiades
Sue Anne Chew
Theano Karadedou
Vassiliki Kotoula
Vassiliki Poulaki
P2860
P304
P356
10.1167/IOVS.11-7398
P407
P577
2011-09-14T00:00:00Z