Impaired processing and presentation of cytotoxic-T-lymphocyte (CTL) epitopes are major escape mechanisms from CTL immune pressure in human immunodeficiency virus type 1 infection.
about
Selection, transmission, and reversion of an antigen-processing cytotoxic T-lymphocyte escape mutation in human immunodeficiency virus type 1 infectionMechanisms of HIV protein degradation into epitopes: implications for vaccine designCD8 Epitope Escape and Reversion in Acute HCV InfectionHepatitis C virus immune escape via exploitation of a hole in the T cell repertoireHigh-programmed death-1 levels on hepatitis C virus-specific T cells during acute infection are associated with viral persistence and require preservation of cognate antigen during chronic infectionEvolutionarily conserved protein sequences of influenza a viruses, avian and human, as vaccine targetsAdaptive interactions between HLA and HIV-1: highly divergent selection imposed by HLA class I molecules with common supertype motifs.CTL escape mediated by proteasomal destruction of an HIV-1 cryptic epitopeHigh epitope expression levels increase competition between T cellsEvidence of differential HLA class I-mediated viral evolution in functional and accessory/regulatory genes of HIV-1The specificity and polymorphism of the MHC class I prevents the global adaptation of HIV-1 to the monomorphic proteasome and TAP.Functional avidity and IL-2/perforin production is linked to the emergence of mutations within HLA-B*5701-restricted epitopes and HIV-1 disease progressionEscape mutations alter proteasome processing of major histocompatibility complex class I-restricted epitopes in persistent hepatitis C virus infection.Signature for long-term vaccine-mediated control of a Simian and human immunodeficiency virus 89.6P challenge: stable low-breadth and low-frequency T-cell response capable of coproducing gamma interferon and interleukin-2.Human immunodeficiency virus type 1 Vpr impairs dendritic cell maturation and T-cell activation: implications for viral immune escape.The antiviral efficacy of HIV-specific CD8⁺ T-cells to a conserved epitope is heavily dependent on the infecting HIV-1 isolate.Unique CRF01_AE Gag CTL epitopes associated with lower HIV-viral load and delayed disease progression in a cohort of HIV-infected Thais.A novel immunodominant CD8+ T cell response restricted by a common HLA-C allele targets a conserved region of Gag HIV-1 clade CRF01_AE infected ThaisDe novo generation of escape variant-specific CD8+ T-cell responses following cytotoxic T-lymphocyte escape in chronic human immunodeficiency virus type 1 infectionQuantifiable cytotoxic T lymphocyte responses and HLA-related risk of progression to AIDSThe effect of HLA polymorphisms on the recognition of Gag epitopes in HIV-1 CRF01_AE infection.Development of a novel in silico docking simulation model for the fine HIV-1 cytotoxic T lymphocyte epitope mapping.Fitness cost of escape mutations in p24 Gag in association with control of human immunodeficiency virus type 1HIV control is mediated in part by CD8+ T-cell targeting of specific epitopes.Potential elucidation of a novel CTL epitope in HIV-1 protease by the protease inhibitor resistance mutation L90M.Selection on the human immunodeficiency virus type 1 proteome following primary infection.High-avidity, high-IFNγ-producing CD8 T-cell responses following immune selection during HIV-1 infection.Variable processing and cross-presentation of HIV by dendritic cells and macrophages shapes CTL immunodominance and immune escape.Rapid reversion of sequence polymorphisms dominates early human immunodeficiency virus type 1 evolution.Multilayered HIV-1 gag-specific T-cell responses contribute to slow progression in HLA-A*30-B*13-C*06-positive patients.Selection and accumulation of an HIV-1 escape mutant by three types of HIV-1-specific cytotoxic T lymphocytes recognizing wild-type and/or escape mutant epitopes.HIV and SIV CTL escape: implications for vaccine design.Rapid HIV-1 Disease Progression in Individuals Infected with a Virus Adapted to Its Host Population.Glances in Immunology of HIV and HCV InfectionPartial escape of HIV-1 from cytotoxic T lymphocytes during chronic infection.Safety and Immunogenicity of the MRKAd5 gag HIV Type 1 Vaccine in a Worldwide Phase 1 Study of Healthy AdultsConstraints on HIV-1 evolution and immunodominance revealed in monozygotic adult twins infected with the same virusA viral CTL escape mutation leading to immunoglobulin-like transcript 4-mediated functional inhibition of myelomonocytic cellsSelective pressures of HLA genotypes and antiviral therapy on human immunodeficiency virus type 1 sequence mutation at a population level.Evolution of human immunodeficiency virus type 1 cytotoxic T-lymphocyte epitopes: fitness-balanced escape.
P2860
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P2860
Impaired processing and presentation of cytotoxic-T-lymphocyte (CTL) epitopes are major escape mechanisms from CTL immune pressure in human immunodeficiency virus type 1 infection.
description
2004 nî lūn-bûn
@nan
2004 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Impaired processing and presen ...... ciency virus type 1 infection.
@ast
Impaired processing and presen ...... ciency virus type 1 infection.
@en
type
label
Impaired processing and presen ...... ciency virus type 1 infection.
@ast
Impaired processing and presen ...... ciency virus type 1 infection.
@en
prefLabel
Impaired processing and presen ...... ciency virus type 1 infection.
@ast
Impaired processing and presen ...... ciency virus type 1 infection.
@en
P2093
P2860
P1433
P1476
Impaired processing and presen ...... ciency virus type 1 infection.
@en
P2093
Ai Kawana-Tachikawa
Aikichi Iwamoto
Asato Kojima
Hideka Miura
Hiroko Tomiyama
Koya Ariyoshi
Masafumi Takiguchi
Yoshiyuki Nagai
Yoshiyuki Yokomaku
Zene Matsuda
P2860
P304
P356
10.1128/JVI.78.3.1324-1332.2004
P407
P577
2004-02-01T00:00:00Z