Mechanism of copper(II)-induced misfolding of Parkinson's disease protein.
about
Low levels of copper disrupt brain amyloid-β homeostasis by altering its production and clearanceThe interactome of the copper transporter ATP7A belongs to a network of neurodevelopmental and neurodegeneration factors.The potential for transition metal-mediated neurodegeneration in amyotrophic lateral sclerosisOverexpression of alpha-synuclein at non-toxic levels increases dopaminergic cell death induced by copper exposure via modulation of protein degradation pathways.Transient β-hairpin formation in α-synuclein monomer revealed by coarse-grained molecular dynamics simulation.Environmental and genetic factors support the dissociation between α-synuclein aggregation and toxicity.Metal Dyshomeostasis and Their Pathological Role in Prion and Prion-Like Diseases: The Basis for a Nutritional Approach.Insight into α-synuclein plasticity and misfolding from differential micelle binding.Antioxidant gene therapy against neuronal cell death.Secondary structure preferences of mn (2+) binding sites in bacterial proteins.Metallothionein, Copper and Alpha-Synuclein in Alpha-Synucleinopathies.The unravelling of metabolic dysfunctions linked to metal-associated diseases by blue native polyacrylamide gel electrophoresis.Interaction of metal ions with neurotransmitter receptors and potential role in neurodiseases.The non-octarepeat copper binding site of the prion protein is a key regulator of prion conversion.Copper(II) and the pathological H50Q α-synuclein mutant: Environment meets genetics.Comparison of the structural characteristics of Cu(2+)-bound and unbound α-syn12 peptide obtained in simulations using different force fields.Chromatin-Bound Oxidized α-Synuclein Causes Strand Breaks in Neuronal Genomes in in vitro Models of Parkinson's Disease.Dexamethasone Inhibits Copper-Induced Alpha-Synuclein Aggregation by a Metallothionein-Dependent Mechanism.Tuning the Balance between Fibrillation and Oligomerization of α-Synuclein in the Presence of Dopamine
P2860
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P2860
Mechanism of copper(II)-induced misfolding of Parkinson's disease protein.
description
2011 nî lūn-bûn
@nan
2011 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Mechanism of copper(II)-induced misfolding of Parkinson's disease protein.
@ast
Mechanism of copper(II)-induced misfolding of Parkinson's disease protein.
@en
type
label
Mechanism of copper(II)-induced misfolding of Parkinson's disease protein.
@ast
Mechanism of copper(II)-induced misfolding of Parkinson's disease protein.
@en
prefLabel
Mechanism of copper(II)-induced misfolding of Parkinson's disease protein.
@ast
Mechanism of copper(II)-induced misfolding of Parkinson's disease protein.
@en
P2860
P356
P1433
P1476
Mechanism of copper(II)-induced misfolding of Parkinson's disease protein
@en
P2093
Frisco Rose
Miroslav Hodak
P2860
P2888
P356
10.1038/SREP00011
P407
P577
2011-06-14T00:00:00Z