Dissociation of the glucose and lipid regulatory functions of FoxO1 by targeted knockin of acetylation-defective alleles in mice
about
Novel repressor regulates insulin sensitivity through interaction with Foxo1Metabolic reprogramming by class I and II histone deacetylasesClass III PI3K regulates organismal glucose homeostasis by providing negative feedback on hepatic insulin signalling.Insulin signaling, resistance, and the metabolic syndrome: insights from mouse models into disease mechanisms.SIRT1 enhances glucose tolerance by potentiating brown adipose tissue functionMS-based metabolomics facilitates the discovery of in vivo functional small molecules with a diversity of biological contexts.A dysregulated acetyl/SUMO switch of FXR promotes hepatic inflammation in obesity.Decreased expression of hepatic glucokinase in type 2 diabetes.Homozygosity for an allele encoding deacetylated FoxO1 protects macrophages from cholesterol-induced inflammation without increasing apoptosis.A mutant allele encoding DNA binding-deficient FoxO1 differentially regulates hepatic glucose and lipid metabolismIncreased atherosclerosis and endothelial dysfunction in mice bearing constitutively deacetylated alleles of Foxo1 gene.Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestrationAcetylation mimic of lysine 280 exacerbates human Tau neurotoxicity in vivoFoxO1 Deacetylation Decreases Fatty Acid Oxidation in β-Cells and Sustains Insulin Secretion in Diabetes.Crosstalk between poly(ADP-ribose) polymerase and sirtuin enzymes.Direct Hepatocyte Insulin Signaling Is Required for Lipogenesis but Is Dispensable for the Suppression of Glucose Production.Generation of mice encoding a conditional allele of Nkx2.2.Tissue-specific metabolic reprogramming drives nutrient flux in diabetic complicationsIntegrating metabolism and longevity through insulin and IGF1 signaling.Preserved energy balance in mice lacking FoxO1 in neurons of Nkx2.1 lineage reveals functional heterogeneity of FoxO1 signaling within the hypothalamus.Dissociating fatty liver and diabetesAn ERK/Cdk5 axis controls the diabetogenic actions of PPARγ.The role of insulin resistance in nonalcoholic steatohepatitis and liver disease development--a potential therapeutic target?When β-cells fail: lessons from dedifferentiation.Loss of TIMP3 underlies diabetic nephropathy via FoxO1/STAT1 interplay.Metabolic Regulation of Angiogenesis in Diabetes and Aging.Sirtuin-1 is a nutrient-dependent modulator of inflammation.Rictor/mTORC2 loss in the Myf5 lineage reprograms brown fat metabolism and protects mice against obesity and metabolic diseaseSelective Inhibition of FOXO1 Activator/Repressor Balance Modulates Hepatic Glucose Handling.Biochemical and cellular properties of insulin receptor signalling.Insulin action and resistance in obesity and type 2 diabetes.Rare copy number variants in patients with congenital conotruncal heart defects.The PI3K/AKT pathway in obesity and type 2 diabetes
P2860
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P2860
Dissociation of the glucose and lipid regulatory functions of FoxO1 by targeted knockin of acetylation-defective alleles in mice
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Dissociation of the glucose an ...... tion-defective alleles in mice
@ast
Dissociation of the glucose an ...... tion-defective alleles in mice
@en
type
label
Dissociation of the glucose an ...... tion-defective alleles in mice
@ast
Dissociation of the glucose an ...... tion-defective alleles in mice
@en
prefLabel
Dissociation of the glucose an ...... tion-defective alleles in mice
@ast
Dissociation of the glucose an ...... tion-defective alleles in mice
@en
P2093
P2860
P50
P1433
P1476
Dissociation of the glucose an ...... tion-defective alleles in mice
@en
P2093
Dina Laznik
Domenico Accili
Garrett Heinrich
Ja Young Kim-Muller
Natalie M Kofler
Teresa L Mastracci
Varman T Samuel
Virginia E Papaioannou
P2860
P304
P356
10.1016/J.CMET.2011.09.012
P577
2011-11-01T00:00:00Z