Basic residues in the T-cell receptor ζ cytoplasmic domain mediate membrane association and modulate signaling.
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An induced rebinding model of antigen discriminationAction and Traction: Cytoskeletal Control of Receptor Triggering at the Immunological SynapseStructural Features of the αβTCR Mechanotransduction Apparatus That Promote pMHC DiscriminationIndoctrinating T cells to attack pathogens through homeschoolingMechanical regulation of T-cell functionsAn intermolecular FRET sensor detects the dynamics of T cell receptor clusteringAccumulation of serial forces on TCR and CD8 frequently applied by agonist antigenic peptides embedded in MHC molecules triggers calcium in T cells.Piecing together the family portrait of TCR-CD3 complexes.Systems model of T cell receptor proximal signaling reveals emergent ultrasensitivity.Dynamic motile T cells highly respond to the T cell stimulation via PI3K-Akt and NF-κB pathways.A Transmembrane Domain GGxxG Motif in CD4 Contributes to Its Lck-Independent Function but Does Not Mediate CD4 DimerizationJuxtamembrane contribution to transmembrane signaling.Membrane dynamics shape TCR-generated signaling.A Mechanical Switch Couples T Cell Receptor Triggering to the Cytoplasmic Juxtamembrane Regions of CD3ζζ.Geometry Dynamics of α -Helices in Different Class I Major Histocompatibility ComplexesAlternative RISC assembly: binding and repression of microRNA-mRNA duplexes by human Ago proteins.Local changes in lipid environment of TCR microclusters regulate membrane binding by the CD3ε cytoplasmic domain.Multisite Phosphorylation Modulates the T Cell Receptor ζ-Chain Potency but not the Switchlike Response.The large ectodomains of CD45 and CD148 regulate their segregation from and inhibition of ligated T-cell receptor.Functional role of T-cell receptor nanoclusters in signal initiation and antigen discriminationA conserved αβ transmembrane interface forms the core of a compact T-cell receptor-CD3 structure within the membrane.Scramblase TMEM16F terminates T cell receptor signaling to restrict T cell exhaustion.Non-catalytic tyrosine-phosphorylated receptors.T cell antigen receptor activation and actin cytoskeleton remodeling.Functions of intrinsic disorder in transmembrane proteins.Regulation of T cell signalling by membrane lipids.CARs: Synthetic Immunoreceptors for Cancer Therapy and Beyond.The integration of signaling and the spatial organization of the T cell synapse.Accumulation of dynamic catch bonds between TCR and agonist peptide-MHC triggers T cell signaling."Cell biology meets physiology: functional organization of vertebrate plasma membranes"--the immunological synapse.On the Control of TCR Phosphorylation.Why do some T cell receptor cytoplasmic domains associate with the plasma membrane?How does the kinase Lck phosphorylate the T cell receptor? Spatial organization as a regulatory mechanism.TCR Signaling Emerges from the Sum of Many PartsMechanical force in T cell receptor signal initiationDynamic regulation of CD28 conformation and signaling by charged lipids and ions.Conformational states of the kinase Lck regulate clustering in early T cell signaling.Unique ζ-chain motifs mediate a direct TCR-actin linkage critical for immunological synapse formation and T-cell activation.Introducing Membrane Charge and Membrane Potential to T Cell Signaling.The cytosolic domain of T-cell receptor ζ associates with membranes in a dynamic equilibrium and deeply penetrates the bilayer.
P2860
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P2860
Basic residues in the T-cell receptor ζ cytoplasmic domain mediate membrane association and modulate signaling.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Basic residues in the T-cell r ...... iation and modulate signaling.
@ast
Basic residues in the T-cell r ...... iation and modulate signaling.
@en
type
label
Basic residues in the T-cell r ...... iation and modulate signaling.
@ast
Basic residues in the T-cell r ...... iation and modulate signaling.
@en
prefLabel
Basic residues in the T-cell r ...... iation and modulate signaling.
@ast
Basic residues in the T-cell r ...... iation and modulate signaling.
@en
P2860
P50
P356
P1476
Basic residues in the T-cell r ...... iation and modulate signaling.
@en
P2093
P2860
P304
19323-19328
P356
10.1073/PNAS.1108052108
P407
P577
2011-11-14T00:00:00Z