Small molecule anti-angiogenic probes of the ubiquitin proteasome pathway: potential application to choroidal neovascularization
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The tumor inhibitor and antiangiogenic agent withaferin A targets the intermediate filament protein vimentinJNK-NQO1 axis drives TAp73-mediated tumor suppression upon oxidative and proteasomal stressWithaferin A targets intermediate filaments glial fibrillary acidic protein and vimentin in a model of retinal gliosisIn vitro inhibition of angiogenesis by antibodies directed against the 37kDa/67kDa laminin receptorWithaferin A effectively targets soluble vimentin in the glaucoma filtration surgical model of fibrosis.Ubiquitin carboxyl-terminal esterase L1 promotes proliferation of human choroidal and retinal endothelial cells.Corneal antifibrotic switch identified in genetic and pharmacological deficiency of vimentinVimentin Phosphorylation Underlies Myofibroblast Sensitivity to Withaferin A In Vitro and during Corneal FibrosisRecent Advances in the Development of Antineoplastic Agents Derived from Natural ProductsStructure-activity relationship (SAR) of withanolides to inhibit Hsp90 for its activity in pancreatic cancer cells.Synthesis and pharmacology of proteasome inhibitors.Natural product inhibitors of ocular angiogenesis.Natural Withanolides in the Treatment of Chronic Diseases.LMP2-specific inhibitors: chemical genetic tools for proteasome biology.A robust model for simultaneously inducing corneal neovascularization and retinal gliosis in the mouse eye.Inhibition of NFkappaB by the natural product Withaferin A in cellular models of Cystic Fibrosis inflammation.Synergistic inhibition of glioma cell proliferation by Withaferin A and tumor treating fields.Upregulation of matrix metalloproteinase triggers transdifferentiation of retinal pigmented epithelial cells in Xenopus laevis: A Link between inflammatory response and regeneration.Angiogenic and Immunologic Proteins Identified by Deep Proteomic Profiling of Human Retinal and Choroidal Vascular Endothelial Cells: Potential Targets for New Biologic Drugs.Recent advances in elucidating the biological properties of Withania somnifera and its potential role in health benefits
P2860
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P2860
Small molecule anti-angiogenic probes of the ubiquitin proteasome pathway: potential application to choroidal neovascularization
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Small molecule anti-angiogenic ...... o choroidal neovascularization
@ast
Small molecule anti-angiogenic ...... o choroidal neovascularization
@en
type
label
Small molecule anti-angiogenic ...... o choroidal neovascularization
@ast
Small molecule anti-angiogenic ...... o choroidal neovascularization
@en
prefLabel
Small molecule anti-angiogenic ...... o choroidal neovascularization
@ast
Small molecule anti-angiogenic ...... o choroidal neovascularization
@en
P2093
P2860
P356
P1476
Small molecule anti-angiogenic ...... o choroidal neovascularization
@en
P2093
Padma Priya Ravindranath
Paola Bargagna-Mohan
Royce Mohan
P2860
P304
P356
10.1167/IOVS.05-1452
P407
P577
2006-09-01T00:00:00Z