Characterization of binding and inhibitory properties of TAK-063, a novel phosphodiesterase 10A inhibitor
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TAK-063, a PDE10A Inhibitor with Balanced Activation of Direct and Indirect Pathways, Provides Potent Antipsychotic-Like Effects in Multiple ParadigmsTAK-063, a Novel Phosphodiesterase 10A Inhibitor, Protects from Striatal Neurodegeneration and Ameliorates Behavioral Deficits in the R6/2 Mouse Model of Huntington's Disease.TAK-063, a novel PDE10A inhibitor with balanced activation of direct and indirect pathways, provides a unique opportunity for the treatment of schizophrenia.Brain PET measurement of PDE10A occupancy by TAK-063, a new PDE10A inhibitor, using [11 C]T-773 in nonhuman primates.Combined treatment with a selective PDE10A inhibitor TAK-063 and either haloperidol or olanzapine at subeffective doses produces potent antipsychotic-like effects without affecting plasma prolactin levels and cataleptic responses in rodents.The Phosphodiesterase 10A Selective Inhibitor TAK-063 Improves Cognitive Functions Associated with Schizophrenia in Rodent Models.Inhibition of Adrenergic and Non-Adrenergic Smooth Muscle Contraction in the Human Prostate by the Phosphodiesterase 10-Selective Inhibitor TC-E 5005.
P2860
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P2860
Characterization of binding and inhibitory properties of TAK-063, a novel phosphodiesterase 10A inhibitor
description
2015 nî lūn-bûn
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2015年の論文
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2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
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name
Characterization of binding an ...... hosphodiesterase 10A inhibitor
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Characterization of binding an ...... hosphodiesterase 10A inhibitor
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type
label
Characterization of binding an ...... hosphodiesterase 10A inhibitor
@ast
Characterization of binding an ...... hosphodiesterase 10A inhibitor
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prefLabel
Characterization of binding an ...... hosphodiesterase 10A inhibitor
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Characterization of binding an ...... hosphodiesterase 10A inhibitor
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P2093
P2860
P1433
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Characterization of binding an ...... hosphodiesterase 10A inhibitor
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P2093
Akina Harada
Haruhide Kimura
Kazunori Suzuki
Kimio Tohyama
Kosuke Nakashima
Maki Miyamoto
Naomi Kamiguchi
Takahiko Taniguchi
P2860
P304
P356
10.1371/JOURNAL.PONE.0122197
P407
P577
2015-03-27T00:00:00Z