Harvey ras genes transform without mutant codons, apparently activated by truncation of a 5' exon (exon -1)
about
Karyotypic evolutions of cancer species in rats during the long latent periods after injection of nitrosourea.Retroviral transduction of oncogenic sequences involves viral DNA instead of RNA.Oncogene v-src transforms and establishes embryonic rodent fibroblasts but not diploid human fibroblasts.A retroviral promoter is sufficient to convert proto-src to a transforming gene that is distinct from the src gene of Rous sarcoma virus.DNA recombination is sufficient for retroviral transduction.Nucleotide sequence and characterization of the 5' flanking region of the rat Ha-ras protooncogeneCancer genes: rare recombinants instead of activated oncogenes (a review).Development of transforming function during transduction of proto-ras into Harvey sarcoma virus.Mutations in ras genes in cells cultured from mouse skin tumors induced by ultraviolet irradiation.A splicing enhancer in the 3'-terminal c-H-ras exon influences mRNA abundance and transforming activityCoordinate N-ras mRNA up-regulation with mutational activation in tumorigenic guinea pig cellsRodent fibroblast tumours expressing human myc and ras genes: growth, metastasis and endogenous oncogene expression.Dominant transformation by mutated human ras genes in vitro requires more than 100 times higher expression than is observed in cancersc-Ha-ras gene bidirectional promoter expressed in vitro: location and regulation.Anoxia-inducible rat VL30 elements and their relationship to ras-containing sarcoma viruses.Recombinant BALB and Harvey sarcoma viruses with normal proto-ras-coding regions transform embryo cells in culture and cause tumors in mice.Harvey murine sarcoma virus: influences of coding and noncoding sequences on cell transformation in vitro and oncogenicity in vivo.The malignant histiocytosis sarcoma virus, a recombinant of Harvey murine sarcoma virus and Friend mink cell focus-forming virus, has acquired myeloid transformation specificity by alterations in the long terminal repeat.Activation of oncogenicity of the c-rel proto-oncogene.Unmutated proto-src coding region is tumorigenic if expressed from the promoter of Rous sarcoma virus: implications for the gene-mutation hypothesis of cancer.Molecular analysis of ras oncogenes in CIN III and in stage I and II invasive squamous cell carcinoma of the uterine cervix.Activated protooncogenes in human lung tumors from smokers.Host range restrictions of oncogenes: myc genes transform avian but not mammalian cells and mht/raf genes transform mammalian but not avian cells.Transforming function of proto-ras genes depends on heterologous promoters and is enhanced by specific point mutations.Cancer genes by illegitimate recombination.Oncogenicity of human N-ras oncogene and proto-oncogene introduced into retroviral vectors.High-level expression of c-H-ras1 fails to fully transform rat-1 cells.Phorbol ester-responsive H-ras1 gene promoter contains multiple TPA-inducible/AP-1-binding consensus sequence elements.
P2860
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P2860
Harvey ras genes transform without mutant codons, apparently activated by truncation of a 5' exon (exon -1)
description
1986 nî lūn-bûn
@nan
1986年の論文
@ja
1986年論文
@yue
1986年論文
@zh-hant
1986年論文
@zh-hk
1986年論文
@zh-mo
1986年論文
@zh-tw
1986年论文
@wuu
1986年论文
@zh
1986年论文
@zh-cn
name
Harvey ras genes transform wit ...... ncation of a 5' exon (exon -1)
@ast
Harvey ras genes transform wit ...... ncation of a 5' exon (exon -1)
@en
type
label
Harvey ras genes transform wit ...... ncation of a 5' exon (exon -1)
@ast
Harvey ras genes transform wit ...... ncation of a 5' exon (exon -1)
@en
prefLabel
Harvey ras genes transform wit ...... ncation of a 5' exon (exon -1)
@ast
Harvey ras genes transform wit ...... ncation of a 5' exon (exon -1)
@en
P2860
P356
P1476
Harvey ras genes transform wit ...... ncation of a 5' exon (exon -1)
@en
P2093
K Cichutek
P2860
P304
P356
10.1073/PNAS.83.8.2340
P407
P577
1986-04-01T00:00:00Z