Site-directed mutagenesis of an invariant amino acid residue at the variable-diversity segments junction of an antibody
about
Protein engineering of antibody binding sites: recovery of specific activity in an anti-digoxin single-chain Fv analogue produced in Escherichia coliStructural correlates of high antibody affinity: three engineered amino acid substitutions can increase the affinity of an anti-p-azophenylarsonate antibody 200-foldThree-dimensional structure of Fab R19.9, a monoclonal murine antibody specific for the p-azobenzenearsonate groupProtein evolution on partially correlated landscapes.V kappa and J kappa gene segments of A/J Ars-A antibodies: somatic recombination generates the essential arginine at the junction of the variable and joining regionsIdentity of the V kappa 10-Ars-A gene segments of the A/J and BALB/c strains.Functional analysis of the antigen binding site on the T cell receptor alpha chainGeneration and characterization of hybridoma antibodies for immunotherapy of tularemia.Variable region sequences of murine IgM anti-IgG monoclonal autoantibodies (rheumatoid factors). II. Comparison of hybridomas derived by lipopolysaccharide stimulation and secondary protein immunization.Influence of the macromolecular form of a B cell epitope on the expression of antibody variable and constant region structure.Structural characterization of antiidiotypic antibodies. Evidence that Ab2s are derived from the germline differently than Ab1sSomatically mutated forms of a major anti-p-azophenylarsonate antibody variable region with drastically reduced affinity for p-azophenylarsonate. By-products of an antigen-driven immune response?Tracing the development of single memory-lineage B cells in a highly defined immune response.Molecular characterization of monoclonal CRIA-positive anti-arsonate antibodies derived from idiotype-negative mice bearing a light chain polymorphism.Molecular analysis of antigen recognition by insulin-specific T-cell hybridomas from B6 wild-type and bm12 mutant mice.Sequencing heavy- and light-chain variable genes of single B-hybridoma cells by total enzymatic amplificationCrystal structure of the antigen-binding fragment of the murine anti-arsonate monoclonal antibody 36-71 at 2.9-A resolution.Anti-DNA antibodies, autoimmunity and the immunoglobulin repertoire.Oligonucleotide-directed mutagenesis of antibody combining sites.Protein engineering. The design, synthesis and characterization of factitious proteins.Differences in antigen-binding affinity caused by a single amino acid substitution in the variable region of the heavy chain.
P2860
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P2860
Site-directed mutagenesis of an invariant amino acid residue at the variable-diversity segments junction of an antibody
description
1986 nî lūn-bûn
@nan
1986年の論文
@ja
1986年論文
@yue
1986年論文
@zh-hant
1986年論文
@zh-hk
1986年論文
@zh-mo
1986年論文
@zh-tw
1986年论文
@wuu
1986年论文
@zh
1986年论文
@zh-cn
name
Site-directed mutagenesis of a ...... gments junction of an antibody
@ast
Site-directed mutagenesis of a ...... gments junction of an antibody
@en
type
label
Site-directed mutagenesis of a ...... gments junction of an antibody
@ast
Site-directed mutagenesis of a ...... gments junction of an antibody
@en
prefLabel
Site-directed mutagenesis of a ...... gments junction of an antibody
@ast
Site-directed mutagenesis of a ...... gments junction of an antibody
@en
P2093
P2860
P356
P1476
Site-directed mutagenesis of a ...... gments junction of an antibody
@en
P2093
P2860
P304
P356
10.1073/PNAS.83.8.2628
P407
P577
1986-04-01T00:00:00Z