Functional imaging of legumain in cancer using a new quenched activity-based probe
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Advancing understanding of microbial bioenergy conversion processes by activity-based protein profilingMicroscopic detection of quenched activity-based optical imaging probes using an antibody detection system: localizing protease activityActivity-based proteomic and metabolomic approaches for understanding metabolismPhotodynamic quenched cathepsin activity based probes for cancer detection and macrophage targeted therapy.FRET-based and other fluorescent proteinase probes.The asparaginyl endopeptidase legumain is essential for functional recovery after spinal cord injury in adult zebrafish.In vivo imaging of specific drug-target binding at subcellular resolution.A Bright Future for Precision Medicine: Advances in Fluorescent Chemical Probe Design and Their Clinical ApplicationFluorogenic Substrates for In Situ Monitoring of Caspase-3 Activity in Live CellsCounter Selection Substrate Library Strategy for Developing Specific Protease Substrates and Probes.Comparative transcriptomics of elasmobranchs and teleosts highlight important processes in adaptive immunity and regional endothermy.Cysteine cathepsin activity suppresses osteoclastogenesis of myeloid-derived suppressor cells in breast cancerTwo-photon Fluorescence Anisotropy Microscopy for Imaging and Direct Measurement of Intracellular Drug Target Engagement.Improved quenched fluorescent probe for imaging of cysteine cathepsin activity.Determining target engagement in living systemsSmall-molecule probes elucidate global enzyme activity in a proteomic context.Strategies in the design of small-molecule fluorescent probes for peptidases.Pathophysiological roles of proteases in gastrointestinal disease.Synthesis and Evaluation of a CBZ-AAN-Dox Prodrug and its in vitro Effects on SiHa Cervical Cancer Cells Under Hypoxic Conditions.Probes to monitor activity of the paracaspase MALT1.Legumain protease-activated TAT-liposome cargo for targeting tumours and their microenvironment.Activity-Based Protein Profiling: From Chemical Novelty to Biomedical Stalwart.Emerging challenges in the design of selective substrates, inhibitors and activity-based probes for indistinguishable proteases.Labeling of active proteases in fresh-frozen tissues by topical application of quenched activity-based probes.Legumain is activated in macrophages during pancreatitis.Distinct Roles of Catalytic Cysteine and Histidine in the Protease and Ligase Mechanisms of Human Legumain As Revealed by DFT-Based QM/MM Simulations.In vivo imaging and biochemical characterization of protease function using fluorescent activity-based probes.Loss of Prkar1a leads to Bcl-2 family protein induction and cachexia in mice.Recognition-driven chemical labeling of endogenous proteins in multi-molecular crowding in live cells.Blockade of Asparagine Endopeptidase Inhibits Cancer Metastasis.Development of a smart activity-based probe to detect subcellular activity of asparaginyl endopeptidase in living cells.Fluorescence anisotropy imaging in drug discovery.Targeted delivery of doxorubicin to tumour tissues by a novel legumain sensitive polygonal nanogel.A novel quenched fluorescent activity-based probe reveals caspase-3 activity in the endoplasmic reticulum during apoptosis† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c5sc03207e.
P2860
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P2860
Functional imaging of legumain in cancer using a new quenched activity-based probe
description
2012 nî lūn-bûn
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2012年の論文
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2012年論文
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2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
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2012年论文
@zh-cn
name
Functional imaging of legumain in cancer using a new quenched activity-based probe
@ast
Functional imaging of legumain in cancer using a new quenched activity-based probe
@en
type
label
Functional imaging of legumain in cancer using a new quenched activity-based probe
@ast
Functional imaging of legumain in cancer using a new quenched activity-based probe
@en
prefLabel
Functional imaging of legumain in cancer using a new quenched activity-based probe
@ast
Functional imaging of legumain in cancer using a new quenched activity-based probe
@en
P2093
P2860
P50
P356
P1476
Functional imaging of legumain in cancer using a new quenched activity-based probe
@en
P2093
Alberto Ortega
Galia Blum
Nimali P Withana
Salahuddin Syed
P2860
P304
P356
10.1021/JA307083B
P407
P577
2012-12-18T00:00:00Z