about
Comparative assessment of substrates and activity based probes as tools for non-invasive optical imaging of cysteine protease activityApplications of small molecule probes in dissecting mechanisms of bacterial virulence and host responsesFalstatin, a cysteine protease inhibitor of Plasmodium falciparum, facilitates erythrocyte invasionA role for the protease falcipain 1 in host cell invasion by the human malaria parasiteCathepsin Activity-Based Probes and Inhibitor for Preclinical Atherosclerosis Imaging and Macrophage DepletionIrAE – An asparaginyl endopeptidase (legumain) in the gut of the hard tick Ixodes ricinusHemoglobin Digestion in Blood-Feeding Ticks: Mapping a Multipeptidase Pathway by Functional ProteomicsDevelopment of calpain-specific inactivators by screening of positional scanning epoxide librariesSmall Molecule-Induced Allosteric Activation of the Vibrio cholerae RTX Cysteine Protease DomainMechanistic and structural insights into the proteolytic activation of Vibrio cholerae MARTX toxinToxoplasma gondii Cathepsin L Is the Primary Target of the Invasion-inhibitory Compound Morpholinurea-leucyl-homophenyl-vinyl Sulfone PhenylRational Design of Inhibitors and Activity-Based Probes Targeting Clostridium difficile Virulence Factor TcdBDefining an allosteric circuit in the cysteine protease domain of Clostridium difficile toxinsFunctional characterization of a SUMO deconjugating protease of Plasmodium falciparum using newly identified small molecule inhibitorsInhibition of cathepsin B reduces beta-amyloid production in regulated secretory vesicles of neuronal chromaffin cells: evidence for cathepsin B as a candidate beta-secretase of Alzheimer's disease4-Bromophenacyl bromide specifically inhibits rhoptry secretion during Toxoplasma invasionNon-invasive imaging of cysteine cathepsin activity in solid tumors using a 64Cu-labeled activity-based probeIdentification of a myeloid-derived suppressor cell cystatin-like protein that inhibits metastasisIncreased nucleolar localization of SpiA3G in classically but not alternatively activated macrophagesA cathepsin L isoform that is devoid of a signal peptide localizes to the nucleus in S phase and processes the CDP/Cux transcription factorMicroscopic detection of quenched activity-based optical imaging probes using an antibody detection system: localizing protease activityTopical application of activity-based probes for visualization of brain tumor tissueSimplified, enhanced protein purification using an inducible, autoprocessing enzyme tagNucleic acid recognition by Toll-like receptors is coupled to stepwise processing by cathepsins and asparagine endopeptidase.Genomics and proteomicsDesign of Protease Activated Optical Contrast Agents That Exploit a Latent Lysosomotropic Effect for Use in Fluorescence-Guided Surgery.Biochemical analysis of the 20 S proteasome of Trypanosoma brucei.Substrate specificity of schistosome versus human legumain determined by P1-P3 peptide libraries.Characteristics of the caspase-like catalytic domain of human paracaspase.Aminopeptidase fingerprints, an integrated approach for identification of good substrates and optimal inhibitors.Chemical approaches for functionally probing the proteome.Small molecule affinity fingerprinting. A tool for enzyme family subclassification, target identification, and inhibitor design.Proteomics meets microbiology: technical advances in the global mapping of protein expression and function.Screening for selective small molecule inhibitors of the proteasome using activity-based probes.Substrate profiling of cysteine proteases using a combinatorial peptide library identifies functionally unique specificities.Design of cell-permeable, fluorescent activity-based probes for the lysosomal cysteine protease asparaginyl endopeptidase (AEP)/legumain.Design, synthesis, and evaluation of in vivo potency and selectivity of epoxysuccinyl-based inhibitors of papain-family cysteine proteases.Identification of proteases that regulate erythrocyte rupture by the malaria parasite Plasmodium falciparum.Applications for chemical probes of proteolytic activity.Substrate specificity of transthyretin: identification of natural substrates in the nervous system.
P50
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P50
name
Matthew Bogyo
@en
type
label
Matthew Bogyo
@en
prefLabel
Matthew Bogyo
@en