The mTOR inhibitor rapamycin down-regulates the expression of the ubiquitin ligase subunit Skp2 in breast cancer cells.
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Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destructionThe Importance of Ubiquitin E3 Ligases, SCF and APC/C, in Human CancersBetter Living through Chemistry: Caloric Restriction (CR) and CR Mimetics Alter Genome Function to Promote Increased Health and LifespanThe physiology and pathophysiology of rapamycin resistance: implications for cancerPhosphorylation by mTORC1 stablizes Skp2 and regulates its oncogenic function in gastric cancerAblation of Akt2 induces autophagy through cell cycle arrest, the downregulation of p70S6K, and the deregulation of mitochondria in MDA-MB231 cells.Neurogenin 3-directed cre deletion of Tsc1 gene causes pancreatic acinar carcinoma.The differential susceptibilities of MCF-7 and MDA-MB-231 cells to the cytotoxic effects of curcumin are associated with the PI3K/Akt-SKP2-Cip/Kips pathway.Mechanism of p27 upregulation induced by downregulation of cathepsin B and uPAR in gliomaThe role of Skp2 in hematopoietic stem cell quiescence, pool size, and self-renewalSarcomas induced in discrete subsets of prospectively isolated skeletal muscle cells.Skp2 is a promising therapeutic target in breast cancer.BRCA1 inhibits AR-mediated proliferation of breast cancer cells through the activation of SIRT1Regulation of Skp2-p27 axis by the Cdh1/anaphase-promoting complex pathway in colorectal tumorigenesis.The effect of rapamycin on DNA synthesis in multiple tissues from late gestation fetal and postnatal ratsMorphoproteomic evidence of constitutively activated and overexpressed mTOR pathway in cervical squamous carcinoma and high grade squamous intraepithelial lesions.Olive Oil-derived Oleocanthal as Potent Inhibitor of Mammalian Target of Rapamycin: Biological Evaluation and Molecular Modeling Studies.SKP2 overexpression is associated with increased serine 10 phosphorylation of p27 (pSer10p27) in triple-negative breast cancer.The expression and prognosis of Emi1 and Skp2 in breast carcinoma: associated with PI3K/Akt pathway and cell proliferation.The effect of mTOR inhibition alone or combined with MEK inhibitors on brain metastasis: an in vivo analysis in triple-negative breast cancer models.Rapamycin potentiates cytotoxicity by docetaxel possibly through downregulation of Survivin in lung cancer cells.Ca(2+)/calmodulin-dependent protein kinase II promotes cell cycle progression by directly activating MEK1 and subsequently modulating p27 phosphorylation.Ornithine decarboxylase inhibition by alpha-difluoromethylornithine activates opposing signaling pathways via phosphorylation of both Akt/protein kinase B and p27Kip1 in neuroblastoma.Protein-mediated viral latency is a novel mechanism for Merkel cell polyomavirus persistence.A brain proteomic investigation of rapamycin effects in the Tsc1+/- mouse model.The impact of Skp2 overexpression on recurrence-free survival following radical prostatectomyKnockdown of AMPKα2 Promotes Pulmonary Arterial Smooth Muscle Cells Proliferation via mTOR/Skp2/p27(Kip1) Signaling Pathway.p53, SKP2, and DKK3 as MYCN Target Genes and Their Potential Therapeutic Significance.EDG2 enhanced the progression of hepatocellular carcinoma by LPA/PI3K/AKT/ mTOR signaling.Statins induce apoptosis through inhibition of Ras signaling pathways and enhancement of Bim and p27 expression in human hematopoietic tumor cells.Activation of AMPK inhibits pulmonary arterial smooth muscle cells proliferation.Emi1 protein accumulation implicates misregulation of the anaphase promoting complex/cyclosome pathway in ovarian clear cell carcinoma.Correction to: The mTOR inhibitor rapamycin down-regulates the expression of the ubiquitin ligase subunit Skp2 in breast cancer cells.
P2860
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P2860
The mTOR inhibitor rapamycin down-regulates the expression of the ubiquitin ligase subunit Skp2 in breast cancer cells.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
The mTOR inhibitor rapamycin d ...... t Skp2 in breast cancer cells.
@ast
The mTOR inhibitor rapamycin d ...... t Skp2 in breast cancer cells.
@en
type
label
The mTOR inhibitor rapamycin d ...... t Skp2 in breast cancer cells.
@ast
The mTOR inhibitor rapamycin d ...... t Skp2 in breast cancer cells.
@en
prefLabel
The mTOR inhibitor rapamycin d ...... t Skp2 in breast cancer cells.
@ast
The mTOR inhibitor rapamycin d ...... t Skp2 in breast cancer cells.
@en
P2093
P2860
P356
P1476
The mTOR inhibitor rapamycin d ...... t Skp2 in breast cancer cells.
@en
P2093
Dan D Hershko
Eli Kakiashvili
Ma'anit Shapira
Tzur Rosenberg
P2860
P2888
P356
10.1186/BCR1533
P577
2006-01-01T00:00:00Z
P5875
P6179
1007566048