TRIP13 is a protein-remodeling AAA+ ATPase that catalyzes MAD2 conformation switching
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The multifaceted roles of the HORMA domain in cellular signalingTRIP13PCH-2 promotes Mad2 localization to unattached kinetochores in the spindle checkpoint responseStructure of the Saccharomyces cerevisiae Hrr25:Mam1 monopolin subcomplex reveals a novel kinase regulator.A Cell Biological Perspective on Past, Present and Future Investigations of the Spindle Assembly CheckpointLoss of thyroid hormone receptor interactor 13 inhibits cell proliferation and survival in human chronic lymphocytic leukemiaTRIP13 impairs mitotic checkpoint surveillance and is associated with poor prognosis in multiple myeloma.Arabidopsis PCH2 Mediates Meiotic Chromosome Remodeling and Maturation of Crossovers.Mode of interaction of TRIP13 AAA-ATPase with the Mad2-binding protein p31comet and with mitotic checkpoint complexes.Intermediates in the assembly of mitotic checkpoint complexes and their role in the regulation of the anaphase-promoting complexTRIP13-deficient tubular epithelial cells are susceptible to apoptosis following acute kidney injury.The Bub1-Plk1 kinase complex promotes spindle checkpoint signalling through Cdc20 phosphorylation.Biallelic TRIP13 mutations predispose to Wilms tumor and chromosome missegregation.DNA repair in ischemic acute kidney injury.Closing the Mad2 cycle.An Arginine Finger Regulates the Sequential Action of Asymmetrical Hexameric ATPase in the Double-Stranded DNA Translocation MotorThe Pch2 AAA+ ATPase promotes phosphorylation of the Hop1 meiotic checkpoint adaptor in response to synaptonemal complex defects.The mitotic checkpoint complex (MCC): looking back and forth after 15 years.TRIP13 is expressed in colorectal cancer and promotes cancer cell invasion.Evolutionary dynamics of the kinetochore network in eukaryotes as revealed by comparative genomics.Synergistic inhibition of the APC/C by the removal of APC15 in HCT116 cells lacking UBE2C.Role of CCT chaperonin in the disassembly of mitotic checkpoint complexes.Conformational dynamics of the Hop1 HORMA domain reveal a common mechanism with the spindle checkpoint protein Mad2.The AAA+ ATPase TRIP13 remodels HORMA domains through N-terminal engagement and unfolding.Molecular Mechanisms of Spindle Assembly Checkpoint Activation and Silencing.Visualizing the complex functions and mechanisms of the anaphase promoting complex/cyclosome (APC/C).Mechanistic insight into TRIP13-catalyzed Mad2 structural transition and spindle checkpoint silencing.Mad2 Overexpression Uncovers a Critical Role for TRIP13 in Mitotic Exit.HDAC2/3 binding and deacetylation of BubR1 initiates spindle assembly checkpoint silencing.Elevated expression of thyroid hormone receptor-interacting protein 13 drives tumorigenesis and affects clinical outcome.Construction of Asymmetrical Hexameric Biomimetic Motors with Continuous Single-Directional Motion by Sequential Coordination.TRIP13 promotes tumor growth and is associated with poor prognosis in colorectal cancer.TRIP13 and APC15 drive mitotic exit by turnover of interphase- and unattached kinetochore-produced MCCMeta-analysis of microarray datasets identify several chromosome segregation-related cancer/testis genes potentially contributing to anaplastic thyroid carcinomaMechanism for remodelling of the cell cycle checkpoint protein MAD2 by the ATPase TRIP13
P2860
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P2860
TRIP13 is a protein-remodeling AAA+ ATPase that catalyzes MAD2 conformation switching
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2015年論文
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2015年論文
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name
TRIP13 is a protein-remodeling AAA+ ATPase that catalyzes MAD2 conformation switching
@ast
TRIP13 is a protein-remodeling AAA+ ATPase that catalyzes MAD2 conformation switching
@en
type
label
TRIP13 is a protein-remodeling AAA+ ATPase that catalyzes MAD2 conformation switching
@ast
TRIP13 is a protein-remodeling AAA+ ATPase that catalyzes MAD2 conformation switching
@en
prefLabel
TRIP13 is a protein-remodeling AAA+ ATPase that catalyzes MAD2 conformation switching
@ast
TRIP13 is a protein-remodeling AAA+ ATPase that catalyzes MAD2 conformation switching
@en
P2860
P50
P356
P1433
P1476
TRIP13 is a protein-remodeling AAA+ ATPase that catalyzes MAD2 conformation switching
@en
P2093
Jeffrey A Speir
Scott C Rosenberg
P2860
P356
10.7554/ELIFE.07367
P407
P577
2015-04-28T00:00:00Z