The HNF-4/HNF-1alpha transactivation cascade regulates gene activity and chromatin structure of the human serine protease inhibitor gene cluster at 14q32.1.
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Formation of a large, complex domain of histone hyperacetylation at human 14q32.1 requires the serpin locus control regionHepatic nuclear factor 1-alpha directs nucleosomal hyperacetylation to its tissue-specific transcriptional targetsCausal and synthetic associations of variants in the SERPINA gene cluster with alpha1-antitrypsin serum levels.Alterations of epigenetic signatures in hepatocyte nuclear factor 4α deficient mouse liver determined by improved ChIP-qPCR and (h)MeDIP-qPCR assays.Differential regulation of gene activity and chromatin structure within the human serpin gene cluster at 14q32.1 in macrophage microcell hybrids.Stable expression and cell-specific chromatin structure of human alpha1-antitrypsin cosmid transgenes in rat hepatoma cells.Cooperation between HNF-1alpha, Cdx2, and GATA-4 in initiating an enterocytic differentiation program in a normal human intestinal epithelial progenitor cell line.Nuclear factor-1-X regulates astrocyte-specific expression of the alpha1-antichymotrypsin and glial fibrillary acidic protein genes.The Peroxisomal 3-keto-acyl-CoA thiolase B Gene Expression Is under the Dual Control of PPARα and HNF4α in the LiverThree missense variants of metabolic syndrome-related genes are associated with alpha-1 antitrypsin levelsThe locus control region activates serpin gene expression through recruitment of liver-specific transcription factors and RNA polymerase II.Astrocyte-specific expression of the alpha1-antichymotrypsin and glial fibrillary acidic protein genes requires activator protein-1.Expression of exogenous human hepatic nuclear factor-1α by a lentiviral vector and its interactions with Plasmodium falciparum subtilisin-like protease 2Interleukin-6-induced STAT3 and AP-1 amplify hepatocyte nuclear factor 1-mediated transactivation of hepatic genes, an adaptive response to liver injury.Astrocyte- and hepatocyte-specific expression of genes from the distal serpin subcluster at 14q32.1 associates with tissue-specific chromatin structures.Identification and functional characterization of a novel mutation of hepatocyte nuclear factor-1alpha gene in a Korean family with MODY3.Direct conversion of human fibroblasts into hepatocyte-like cells by ATF5, PROX1, FOXA2, FOXA3, and HNF4A transduction.
P2860
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P2860
The HNF-4/HNF-1alpha transactivation cascade regulates gene activity and chromatin structure of the human serine protease inhibitor gene cluster at 14q32.1.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
1999年论文
@zh
1999年论文
@zh-cn
name
The HNF-4/HNF-1alpha transacti ...... bitor gene cluster at 14q32.1.
@ast
The HNF-4/HNF-1alpha transacti ...... bitor gene cluster at 14q32.1.
@en
type
label
The HNF-4/HNF-1alpha transacti ...... bitor gene cluster at 14q32.1.
@ast
The HNF-4/HNF-1alpha transacti ...... bitor gene cluster at 14q32.1.
@en
prefLabel
The HNF-4/HNF-1alpha transacti ...... bitor gene cluster at 14q32.1.
@ast
The HNF-4/HNF-1alpha transacti ...... bitor gene cluster at 14q32.1.
@en
P2860
P356
P1476
The HNF-4/HNF-1alpha transacti ...... bitor gene cluster at 14q32.1.
@en
P2093
R E Fournier
P2860
P304
10308-10313
P356
10.1073/PNAS.96.18.10308
P407
P577
1999-08-01T00:00:00Z