Adaptor protein interactions: modulators of amyloid precursor protein metabolism and Alzheimer's disease risk?
about
Growth arrest-specific 1 binds to and controls the maturation and processing of the amyloid-beta precursor proteinStructural basis for polyproline recognition by the FE65 WW domainThe amyloid-beta precursor protein: integrating structure with biological functionLipoprotein receptors and cholesterol in APP trafficking and proteolytic processing, implications for Alzheimer's diseaseThe amyloid precursor protein: beyond amyloidSoluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APPGenetic dissection of the amyloid precursor protein in developmental function and amyloid pathogenesisTrafficking regulation of proteins in Alzheimer's diseasePlatelets and Alzheimer's disease: Potential of APP as a biomarkerCrystal structure of the human Fe65-PTB1 domainAPP processing in Alzheimer's diseaseMolecular interactions position Mso1p, a novel PTB domain homologue, in the interface of the exocyst complex and the exocytic SNARE machinery in yeast.DAB1 and Reelin effects on amyloid precursor protein and ApoE receptor 2 trafficking and processingXB130/Tks5 scaffold protein interaction regulates Src-mediated cell proliferation and survivalIntracellular trafficking and synaptic function of APL-1 in Caenorhabditis elegansEssential roles for the FE65 amyloid precursor protein-interacting proteins in brain developmentEssential roles for Fe65, Alzheimer amyloid precursor-binding protein, in the cellular response to DNA damageFE65 interacts with ADP-ribosylation factor 6 to promote neurite outgrowthA role for FE65 in controlling GnRH-1 neurogenesis.Rab6 interacts with the mint3 adaptor protein.Tyr(682) in the intracellular domain of APP regulates amyloidogenic APP processing in vivo.Positive evolutionary selection of an HD motif on Alzheimer precursor protein orthologues suggests a functional role.Knockdown of amyloid precursor protein in zebrafish causes defects in motor axon outgrowth.Neddylation dysfunction in Alzheimer's disease.Amyloid-beta protein precursor (AbetaPP) intracellular domain-associated protein-1 proteins bind to AbetaPP and modulate its processing in an isoform-specific manner.PAT1a modulates intracellular transport and processing of amyloid precursor protein (APP), APLP1, and APLP2.A single tyrosine residue in the amyloid precursor protein intracellular domain is essential for developmental function.The intracellular threonine of amyloid precursor protein that is essential for docking of Pin1 is dispensable for developmental function.The intracellular domain of sortilin interacts with amyloid precursor protein and regulates its lysosomal and lipid raft traffickingIdentification of NEEP21 as a ß-amyloid precursor protein-interacting protein in vivo that modulates amyloidogenic processing in vitro.Fyn knock-down increases Aβ, decreases phospho-tau, and worsens spatial learning in 3×Tg-AD miceAPP is phosphorylated by TrkA and regulates NGF/TrkA signaling.Retention in endoplasmic reticulum 1 (RER1) modulates amyloid-β (Aβ) production by altering trafficking of γ-secretase and amyloid precursor protein (APP).RNAi-mediated knock-down of Dab and Numb attenuate Aβ levels via γ-secretase mediated APP processing.Ectodomain shedding of the amyloid precursor protein: cellular control mechanisms and novel modifiers.Numb endocytic adapter proteins regulate the transport and processing of the amyloid precursor protein in an isoform-dependent manner: implications for Alzheimer disease pathogenesisMembrane microdomain switching: a regulatory mechanism of amyloid precursor protein processing.Structural studies of the transmembrane C-terminal domain of the amyloid precursor protein (APP): does APP function as a cholesterol sensor?The interactome of the amyloid beta precursor protein family members is shaped by phosphorylation of their intracellular domains.Ubiquitylation of Fe65 adaptor protein by neuronal precursor cell expressed developmentally down regulated 4-2 (Nedd4-2) via the WW domain interaction with Fe65.
P2860
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P2860
Adaptor protein interactions: modulators of amyloid precursor protein metabolism and Alzheimer's disease risk?
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Adaptor protein interactions: ...... and Alzheimer's disease risk?
@ast
Adaptor protein interactions: ...... and Alzheimer's disease risk?
@en
type
label
Adaptor protein interactions: ...... and Alzheimer's disease risk?
@ast
Adaptor protein interactions: ...... and Alzheimer's disease risk?
@en
prefLabel
Adaptor protein interactions: ...... and Alzheimer's disease risk?
@ast
Adaptor protein interactions: ...... and Alzheimer's disease risk?
@en
P1476
Adaptor protein interactions: ...... and Alzheimer's disease risk?
@en
P2093
Gwendalyn D King
R Scott Turner
P304
P356
10.1016/J.EXPNEUROL.2003.10.011
P407
P577
2004-02-01T00:00:00Z