Age-associated neuronal atrophy occurs in the primate brain and is reversible by growth factor gene therapy - Wikidata - awgldk - TriplyDB

Age-associated neuronal atrophy occurs in the primate brain and is reversible by growth factor gene therapy

Age-associated neuronal atrophy occurs in the primate brain and is reversible by growth factor gene therapy

http://www.wikidata.org/entity/Q35636444

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Gene therapy in clinical medicine Original Nerve Growth Factor Mimetic Dipeptide GK-2 Restores Impaired Cognitive Functions in Rat Models of Alzheimer's Disease Local and remote growth factor effects after primate spinal cord injury.Differential effects of intrastriatal 6-hydroxydopamine on cell number and morphology in midbrain dopaminergic subregions of the rat Dissecting the effect of aging on the neural substrates of memory: deterioration, preservation or functional reorganization?Neuroregeneration in neurodegenerative disorders.Human gene therapy and imaging in neurological diseases.Alzheimer-like neurodegeneration in aged antinerve growth factor transgenic mice Estrogen therapy and cognition: a review of the cholinergic hypothesis Failed retrograde transport of NGF in a mouse model of Down's syndrome: reversal of cholinergic neurodegenerative phenotypes following NGF infusion.Oestrogen and nerve growth factor - neuroprotection and repair in Alzheimer's disease.Nontropic actions of neurotrophins: subcortical nerve growth factor gene delivery reverses age-related degeneration of primate cortical cholinergic innervation.Nerve growth factor and galantamine ameliorate early signs of neurodegeneration in anti-nerve growth factor mice.Evaluation of a combined therapeutic regimen of 8-OH-DPAT and environmental enrichment after experimental traumatic brain injury.GPR30 co-localizes with cholinergic neurons in the basal forebrain and enhances potassium-stimulated acetylcholine release in the hippocampus.Normal genetic variation, cognition, and aging.The role of nerve growth factor receptors in cholinergic basal forebrain degeneration in prodromal Alzheimer disease.GPR30 is positioned to mediate estrogen effects on basal forebrain cholinergic neurons and cognitive performance.Regional protein levels of cytosolic phospholipase A2 and cyclooxygenase-2 in Rhesus monkey brain as a function of age Donepezil plus estradiol treatment enhances learning and delay-dependent memory performance by young ovariectomized rats with partial loss of septal cholinergic neurons Cholinergic degeneration and memory loss delayed by vitamin E in a Down syndrome mouse model.Biologic and plastic effects of experimental traumatic brain injury treatment paradigms and their relevance to clinical rehabilitation.Neurotrophins and neurodegeneration.Lessons from the analysis of nonhuman primates for understanding human aging and neurodegenerative diseases Gene therapy for neurological disease.Galanthamine plus estradiol treatment enhances cognitive performance in aged ovariectomized rats.Reactivation of atrophic neurons in Alzheimer's disease.Gene Therapy Models of Alzheimer's Disease and Other Dementias.Current advances in using neurotrophic factors to treat neurodegenerative disorders Positive allosteric modulator of α7 nicotinic-acetylcholine receptors, PNU-120596 augments the effects of donepezil on learning and memory in aged rodents and non-human primates.Neurotrophic factors in neurodegeneration.Cytoskeletal transport in the aging brain: focus on the cholinergic system.Specific mechanism for blood inflow stimulation in brain area prone to Alzheimer's disease lesions.Long-term reversal of cholinergic neuronal decline in aged non-human primates by lentiviral NGF gene delivery A comparison of model-based (2D) and design-based (3D) stereological methods for estimating cell number in the substantia nigra pars compacta (SNpc) of the C57BL/6J mouse Gene therapy in Alzheimer's disease - potential for disease modification Effects of two years of conjugated equine estrogens on cholinergic neurons in young and middle-aged ovariectomized monkeys Therapy of neurodegenerative diseases using neurotrophic factors: cell biological perspective.Effects of fibroblast transplantation into the internal pallidum on levodopa-induced dyskinesias in parkinsonian non-human primates.Non human primate models for Alzheimer's disease-related research and drug discovery.

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P2860

Age-associated neuronal atrophy occurs in the primate brain and is reversible by growth factor gene therapy

http://www.wikidata.org/entity/Q35636444

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Age-associated neuronal atroph ...... by growth factor gene therapy

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Age-associated neuronal atroph ...... by growth factor gene therapy

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Age-associated neuronal atroph ...... by growth factor gene therapy

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D E Smith

http://www.w3.org/2001/XMLSchema#string

F H Gage

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J Roberts

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M H Tuszynski

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P2860

The cholinergic hypothesis of geriatric memory dysfunction

Nerve growth factor in Alzheimer's disease: increased levels throughout the brain coupled with declines in nucleus basalis.

Bridging grafts and transient nerve growth factor infusions promote long-term central nervous system neuronal rescue and partial functional recovery.

Circuit-specific alterations of N-methyl-D-aspartate receptor subunit 1 in the dentate gyrus of aged monkeys.

The aged monkey basal forebrain: rescue and sprouting of axotomized basal forebrain neurons after grafts of encapsulated cells secreting human nerve growth factor.

Long-term functional recovery from age-induced spatial memory impairments by nerve growth factor gene transfer to the rat basal forebrain.

Memory, language, and ageing.

Neuron numbers and dendritic extent in normal aging and Alzheimer's disease.

Alzheimer's disease: a disorder of cortical cholinergic innervation.

Ascending cholinergic pathways: functional organization and implications for disease models.

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