Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia
about
Genes associated with Alzheimer's disease: an overview and current statusOncogene Overdose: Too Much of a Bad Thing for Oncogene-Addicted Cancer CellsTargeting the 5T4 oncofetal glycoprotein with an antibody drug conjugate (A1mcMMAF) improves survival in patient-derived xenograft models of acute lymphoblastic leukemia.Differential Effect of Cytomegalovirus Infection with Age on the Expression of CD57, CD300a, and CD161 on T-Cell Subpopulations.Rationale for targeting the pre-B-cell receptor signaling pathway in acute lymphoblastic leukemia.The Expression Pattern of the Pre-B Cell Receptor Components Correlates with Cellular Stage and Clinical Outcome in Acute Lymphoblastic Leukemia.Synthesis and initial evaluation of quinoline-based inhibitors of the SH2-containing inositol 5'-phosphatase (SHIP).BCR and co-receptor crosstalk facilitate the positive selection of self-reactive transitional B cells.AMPK Is Essential to Balance Glycolysis and Mitochondrial Metabolism to Control T-ALL Cell Stress and Survival.The expression and function of human CD300 receptors on blood circulating mononuclear cells are distinct in neonates and adultsPTEN opposes negative selection and enables oncogenic transformation of pre-B cells.Lineage-Specific Genes Are Prominent DNA Damage Hotspots during Leukemic Transformation of B Cell Precursors.The pre-B-cell receptor checkpoint in acute lymphoblastic leukaemia.Inhibitory leukocyte immunoglobulin-like receptors in cancer development.Inhibitory leukocyte immunoglobulin-like receptors: Immune checkpoint proteins and tumor sustaining factors.Pre-BCR signaling in precursor B-cell acute lymphoblastic leukemia regulates PI3K/AKT, FOXO1 and MYC, and can be targeted by SYK inhibition.Regulation of immune cell signaling by SHIP1: A phosphatase, scaffold protein, and potential therapeutic target.CD99 is a therapeutic target on disease stem cells in myeloid malignancies.Reversing the Paradigm: Protein Kinase C as a Tumor Suppressor.Antiviral properties of resveratrol against pseudorabies virus are associated with the inhibition of IκB kinase activation.GATA Factor-Regulated Samd14 Enhancer Confers Red Blood Cell Regeneration and Survival in Severe Anemia.Intermittent dosing in melanoma.SHIP-1 Couples to the Dectin-1 hemITAM and Selectively Modulates Reactive Oxygen Species Production in Dendritic Cells in Response to Candida albicansSleeping Beauty transposon screen identifies signaling modules that cooperate with STAT5 activation to induce B-cell acute lymphoblastic leukemiaSyk inhibitors in clinical development for hematological malignancies.Kinase overexpressing cancers responsive to drug withdrawal.Suppressors and activators of JAK-STAT signaling at diagnosis and relapse of acute lymphoblastic leukemia in Down syndrome.SHIP1, but not an AML-derived SHIP1 mutant, suppresses myeloid leukemia growth in a xenotransplantation mouse model.Dynamic pre-BCR homodimers fine-tune autonomous survival signals in B cell precursor acute lymphoblastic leukemia.SYK kinase mediates brown fat differentiation and activation.Decreased production of class-switched antibodies in neonatal B cells is associated with increased expression of miR-181b.Themis2 lowers the threshold for B cell activation during positive selection.EphA3 as a target for antibody immunotherapy in acute lymphoblastic leukemia.SHP-1 regulates hematopoietic stem cell quiescence by coordinating TGF-β signaling.Treatment of B-cell precursor acute lymphoblastic leukemia with the Galectin-1 inhibitor PTX008.CD300A promotes tumor progression by PECAM1, ADCY7 and AKT pathway in acute myeloid leukemia.Combined inhibition of receptor tyrosine and p21-activated kinases as a therapeutic strategy in childhood ALL
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P2860
Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia
@ast
Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia
@en
type
label
Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia
@ast
Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia
@en
prefLabel
Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia
@ast
Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia
@en
P2093
P2860
P50
P356
P1433
P1476
Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia
@en
P2093
Andre Limnander
Anne Satterthwaite
Ari Melnick
Björn Titz
Cheryl L Willman
Clifford A Lowell
Eugene Park
Hassan Jumaa
Huimin Geng
Jae U Jung
P2860
P2888
P304
P356
10.1038/NATURE14231
P407
P577
2015-03-23T00:00:00Z