Monophosphorylation of CD79a and CD79b ITAM motifs initiates a SHIP-1 phosphatase-mediated inhibitory signaling cascade required for B cell anergy.
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The outcome of B-cell receptor signaling in chronic lymphocytic leukemia: proliferation or anergyB lymphocyte antigen receptor signaling: initiation, amplification, and regulationPhosphorylation site dynamics of early T-cell receptor signalingHydrogen Peroxide Triggers a Dual Signaling Axis To Selectively Suppress Activated Human T Lymphocyte Migration.A balance between B cell receptor and inhibitory receptor signaling controls plasma cell differentiation by maintaining optimal Ets1 levelsOptimal aggregation of FcεRI with a structurally defined trivalent ligand overrides negative regulation driven by phosphatases.B-cell receptor signaling as a driver of lymphoma development and evolution.Of ITIMs, ITAMs, and ITAMis: revisiting immunoglobulin Fc receptor signaling.N-wasp is essential for the negative regulation of B cell receptor signaling.Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemiaB cell expression of the SH2-containing inositol 5-phosphatase (SHIP-1) is required to establish anergy to high affinity, proteinacious autoantigens.The phosphoinositide 3-kinase signaling pathway in normal and malignant B cells: activation mechanisms, regulation and impact on cellular functions.TLR9 promotes tolerance by restricting survival of anergic anti-DNA B cells, yet is also required for their activation.The structural wedge domain of the receptor-like tyrosine phosphatase CD45 enforces B cell tolerance by regulating substrate specificity.Single-cell measurements of IgE-mediated FcεRI signaling using an integrated microfluidic platformAutoimmunity risk alleles: hotspots in B cell regulatory signaling pathways.Continuous inhibitory signaling by both SHP-1 and SHIP-1 pathways is required to maintain unresponsiveness of anergic B cells.Phosphatase regulation of immunoreceptor signaling in T cells, B cells and mast cells.Activation of the B cell receptor leads to increased membrane proximity of the Igα cytoplasmic domainA role for IRF8 in B cell anergy.Deletion of microRNA-155 reduces autoantibody responses and alleviates lupus-like disease in the Fas(lpr) mouseAberrant antibody affinity selection in SHIP-deficient B cells.Anti-CD79 antibody induces B cell anergy that protects against autoimmunity.Fc receptor-targeted therapies for the treatment of inflammation, cancer and beyond.Microglial activatory (immunoreceptor tyrosine-based activation motif)- and inhibitory (immunoreceptor tyrosine-based inhibition motif)-signaling receptors for recognition of the neuronal glycocalyx.Aberrant B cell selection and activation in systemic lupus erythematosus.The pivotal position of the actin cytoskeleton in the initiation and regulation of B cell receptor activation.Actin-mediated feedback loops in B-cell receptor signaling.Autoantigens: novel forms and presentation to the immune system.Atypical Response of B-1 Cells to BCR Ligation: A Speculative Model.The actin cytoskeleton coordinates the signal transduction and antigen processing functions of the B cell antigen receptor.Signaling mechanisms regulating B-lymphocyte activation and tolerance.Molecular Mechanisms of B Cell Antigen Gathering and Endocytosis.Lyn and Fyn function as molecular switches that control immunoreceptors to direct homeostasis or inflammationTREM2 in Neurodegenerative Diseases.A dual positive and negative regulation of monocyte activation by leukocyte Ig-like receptor B4 depends on the position of the tyrosine residues in its ITIMs.The Dok-3/Grb2 adaptor module promotes inducible association of the lipid phosphatase SHIP with the BCR in a coreceptor-independent manner.FcγRIIB-Independent Mechanisms Controlling Membrane Localization of the Inhibitory Phosphatase SHIP in Human B Cells.Regulation of immune cell signaling by SHIP1: A phosphatase, scaffold protein, and potential therapeutic target.Targeting B cells in treatment of autoimmunity.
P2860
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P2860
Monophosphorylation of CD79a and CD79b ITAM motifs initiates a SHIP-1 phosphatase-mediated inhibitory signaling cascade required for B cell anergy.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Monophosphorylation of CD79a a ...... de required for B cell anergy.
@ast
Monophosphorylation of CD79a a ...... de required for B cell anergy.
@en
type
label
Monophosphorylation of CD79a a ...... de required for B cell anergy.
@ast
Monophosphorylation of CD79a a ...... de required for B cell anergy.
@en
prefLabel
Monophosphorylation of CD79a a ...... de required for B cell anergy.
@ast
Monophosphorylation of CD79a a ...... de required for B cell anergy.
@en
P2093
P2860
P1433
P1476
Monophosphorylation of CD79a a ...... de required for B cell anergy.
@en
P2093
Andrew Getahun
Idan Tamir
John C Cambier
Joseph M Dal Porto
Kevin T Merrell
Mia J Smith
Quan-Zhen Li
Shannon K O'Neill
Stephen B Gauld
P2860
P304
P356
10.1016/J.IMMUNI.2011.10.011
P407
P577
2011-11-09T00:00:00Z