Heparan sulfate and heparanase play key roles in mouse β cell survival and autoimmune diabetes. - Wikidata - awgldk - TriplyDB

Heparan sulfate and heparanase play key roles in mouse β cell survival and autoimmune diabetes.

Heparan sulfate and heparanase play key roles in mouse β cell survival and autoimmune diabetes.

http://www.wikidata.org/entity/Q35640553

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Pathophysiology of heparan sulphate: many diseases, few drugs Islet inflammation: a unifying target for diabetes treatment?Tissue engineering approaches to cell-based type 1 diabetes therapy Involvement of heparanase in atherosclerosis and other vessel wall pathologies Cancer biology in diabetes.Modification of heparanase gene expression in response to conditioning and LPS treatment: strong correlation to rs4693608 SNP.Regulation of the JNK3 signaling pathway during islet isolation: JNK3 and c-fos as new markers of islet quality for transplantation.Hyaluronan and hyaluronan-binding proteins accumulate in both human type 1 diabetic islets and lymphoid tissues and associate with inflammatory cells in insulitis.Glyphosate, pathways to modern diseases II: Celiac sprue and gluten intolerance Heparan sulfate containing unsubstituted glucosamine residues: biosynthesis and heparanase-inhibitory activity.The detection of glycosaminoglycans in pancreatic islets and lymphoid tissues.Extracellular matrix components in the pathogenesis of type 1 diabetes.Carriers of loss-of-function mutations in EXT display impaired pancreatic beta-cell reserve due to smaller pancreas volume DNA methylation of heparanase promoter influences its expression and associated with the progression of human breast cancer Pro-inflammatory and pro-oxidant status of pancreatic islet in vitro is controlled by TLR-4 and HO-1 pathways.Involvement of Heparanase in Empyema: Implication for Novel Therapeutic Approaches Lung-Derived Microscaffolds Facilitate Diabetes Reversal after Mouse and Human Intraperitoneal Islet Transplantation Inhibition of hyaluronan synthesis restores immune tolerance during autoimmune insulitis The role of hyaluronan and the extracellular matrix in islet inflammation and immune regulation.Deciphering mode of action of heparanase using structurally defined oligosaccharides.Hyaluronan and hyaluronan binding proteins are normal components of mouse pancreatic islets and are differentially expressed by islet endocrine cell types Heparanase-neutralizing antibodies attenuate lymphoma tumor growth and metastasis Pathogenic mechanisms in type 1 diabetes: the islet is both target and driver of disease.Heparan sulfate: a ubiquitous glycosaminoglycan with multiple roles in immunity Heparanase and autoimmune diabetes.Heparanase interacts with resistin and augments its activity.Profiling of circulating microRNAs in children with recent onset of type 1 diabetes.Heparanase augments insulin receptor signaling in breast carcinoma.The heparanase/syndecan-1 axis in cancer: mechanisms and therapies.Heparanase in inflammation and inflammation-associated cancer.Heparan sulfate inhibitors and their therapeutic implications in inflammatory illnesses.Endothelial glycocalyx-the battleground for complications of sepsis and kidney injury.Heparan Sulfate Proteoglycans Are Important for Islet Amyloid Formation and Islet Amyloid Polypeptide-induced Apoptosis.Heparanase regulation of cancer, autophagy and inflammation: new mechanisms and targets for therapy.Heparanase: roles in cell survival, extracellular matrix remodelling and the development of kidney disease.Pancreatic islet basement membrane loss and remodeling after mouse islet isolation and transplantation: impact for allograft rejection.Interaction between castanospermine an immunosuppressant and cyclosporin A in rat cardiac transplantation.Involvement of heparan sulfate 3-O-sulfotransferase isoform-1 in the insulin secretion pathway.Syndecan-4 is associated with beta-cells in the pancreas and the MIN6 beta-cell line.Intra-islet endothelial cell and β-cell crosstalk: Implication for islet cell transplantation.

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P2860

Heparan sulfate and heparanase play key roles in mouse β cell survival and autoimmune diabetes.

http://www.wikidata.org/entity/Q35640553

description

2011 nî lūn-bûn

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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2011年论文

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2011年论文

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name

Heparan sulfate and heparanase ...... vival and autoimmune diabetes.

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Heparan sulfate and heparanase ...... vival and autoimmune diabetes.

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type

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Heparan sulfate and heparanase ...... vival and autoimmune diabetes.

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Heparan sulfate and heparanase ...... vival and autoimmune diabetes.

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Heparan sulfate and heparanase ...... vival and autoimmune diabetes.

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Heparan sulfate and heparanase ...... vival and autoimmune diabetes.

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Journal of Clinical Investigation

P1476

Heparan sulfate and heparanase ...... vival and autoimmune diabetes.

@en

P2093

Andrew F Ziolkowski

http://www.w3.org/2001/XMLSchema#string

Charmaine J Simeonovic

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Christopher R Parish

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Craig Freeman

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Sarah K Popp

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P2860

Mammalian heparanase: gene cloning, expression and function in tumor progression and metastasis

Processing and activation of latent heparanase occurs in lysosomes

Cloning of mammalian heparanase, an important enzyme in tumor invasion and metastasis

Heparanase in glomerular diseases

Inhibition of glomerular cell apoptosis by heparin

Mcl-1 downregulation by pro-inflammatory cytokines and palmitate is an early event contributing to β-cell apoptosis

Functions of cell surface heparan sulfate proteoglycans

Order out of chaos: assembly of ligand binding sites in heparan sulfate

Glucans exhibit weak antioxidant activity, but stimulate macrophage free radical activity.

Protective effect of ultra low molecular weight heparin on glutamate-induced apoptosis in cortical cells

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132-141

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10.1172/JCI46177

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1

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122

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2011-12-19T00:00:00Z

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22182841

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3248281

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