Covalent and noncovalent modification of thin filament action: the essential role of troponin in cardiac muscle regulation.
about
Phosphorylation of cardiac troponin I by mammalian sterile 20-like kinase 1TNNI3K is a novel mediator of myofilament function and phosphorylates cardiac troponin ICardiac Troponins in Dogs and CatsIntegration of troponin I phosphorylation with cardiac regulatory networksCell biology of sarcomeric protein engineering: disease modeling and therapeutic potentialMaturation status of sarcomere structure and function in human iPSC-derived cardiac myocytesWhy does troponin I have so many phosphorylation sites? Fact and fancyThin filament mutations: developing an integrative approach to a complex disorderA preferred AMPK phosphorylation site adjacent to the inhibitory loop of cardiac and skeletal troponin IDifferential contribution of troponin I phosphorylation sites to the endothelin-modulated contractile responseStructure and function of cardiac troponin C (TNNC1): Implications for heart failure, cardiomyopathies, and troponin modulating drugsPathogenic peptide deviations support a model of adaptive evolution of chordate cardiac performance by troponin mutations.PKCβII modulation of myocyte contractile performance.Diastolic dysfunction and thin filament dysregulation resulting from excitation-contraction uncoupling in a mouse model of restrictive cardiomyopathy.Molecular inotropy mediated by cardiac miR-based PDE4D/PRKAR1α/phosphoprotein signalingEffect of calcium-sensitizing mutations on calcium binding and exchange with troponin C in increasingly complex biochemical systems.Phosphorylation of cardiac troponin I at protein kinase C site threonine 144 depresses cooperative activation of thin filaments.Calcium sensitivity, force frequency relationship and cardiac troponin I: critical role of PKA and PKC phosphorylation sitesExcision of titin's cardiac PEVK spring element abolishes PKCalpha-induced increases in myocardial stiffnessStructural and kinetic effects of PAK3 phosphorylation mimic of cTnI(S151E) on the cTnC-cTnI interaction in the cardiac thin filamentNovel function of cardiac protein kinase D1 as a dynamic regulator of Ca2+ sensitivity of contractionAcquisition of a quantitative, stoichiometrically conserved ratiometric marker of maturation status in stem cell-derived cardiac myocytes.Protein kinase D isoforms are activated in an agonist-specific manner in cardiomyocytes.Cardiac peroxisome proliferator-activated receptor δ (PPARδ) as a new target for increased contractility without altering heart rate.Characterization of the mechanisms of the increase in PPARδ expression induced by digoxin in the heart using the H9c2 cell line.Adenylyl cyclase 6 improves calcium uptake and left ventricular function in aged heartsCardiac troponin I Pro82Ser variant induces diastolic dysfunction, blunts β-adrenergic response, and impairs myofilament cooperativityPKCα-specific phosphorylation of the troponin complex in human myocardium: a functional and proteomics analysis.AHR2-Mediated transcriptomic responses underlying the synergistic cardiac developmental toxicity of PAHsEffects of nicotine administration in a mouse model of familial hypertrophic cardiomyopathy, α-tropomyosin D175N.Pseudo-acetylation of K326 and K328 of actin disrupts Drosophila melanogaster indirect flight muscle structure and performancepH-responsive titratable inotropic performance of histidine-modified cardiac troponin I.Engineered troponin C constructs correct disease-related cardiac myofilament calcium sensitivity.Single amino acid substitutions define isoform-specific effects of troponin I on myofilament Ca2+ and pH sensitivity.Cardiac-specific deletion of protein phosphatase 1β promotes increased myofilament protein phosphorylation and contractile alterationsHeart failure, myocardial stunning, and troponin: a key regulator of the cardiac myofilament.Significance of troponin dynamics for Ca2+-mediated regulation of contraction and inherited cardiomyopathy.Blood cardiac troponin in toxic myocardial injury: archetype of a translational safety biomarker.Alpha1 catalytic subunit of AMPK modulates contractile function of cardiomyocytes through phosphorylation of troponin I.Allele and species dependent contractile defects by restrictive and hypertrophic cardiomyopathy-linked troponin I mutants
P2860
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P2860
Covalent and noncovalent modification of thin filament action: the essential role of troponin in cardiac muscle regulation.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Covalent and noncovalent modif ...... in cardiac muscle regulation.
@ast
Covalent and noncovalent modif ...... in cardiac muscle regulation.
@en
type
label
Covalent and noncovalent modif ...... in cardiac muscle regulation.
@ast
Covalent and noncovalent modif ...... in cardiac muscle regulation.
@en
prefLabel
Covalent and noncovalent modif ...... in cardiac muscle regulation.
@ast
Covalent and noncovalent modif ...... in cardiac muscle regulation.
@en
P1433
P1476
Covalent and noncovalent modif ...... n in cardiac muscle regulation
@en
P2093
Joseph M Metzger
P304
P356
10.1161/01.RES.0000110083.17024.60
P50
P577
2004-02-01T00:00:00Z