Hedgehog signaling maintains a tumor stem cell compartment in multiple myeloma. - Wikidata - awgldk - TriplyDB

Hedgehog signaling maintains a tumor stem cell compartment in multiple myeloma.

Hedgehog signaling maintains a tumor stem cell compartment in multiple myeloma.

http://www.wikidata.org/entity/Q35652021

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Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector Clonogenic multiple myeloma progenitors, stem cell properties, and drug resistance Hedgehog signaling overrides p53-mediated tumor suppression by activating Mdm2 Anti-Cancer Stem-like Cell Compounds in Clinical Development - An Overview and Critical Appraisal Therapeutic Effectiveness of Anticancer Phytochemicals on Cancer Stem Cells Multiple myeloma cancer stem cells Esophageal cancer stem cells and implications for future therapeutics Targeting self-renewal pathways in cancer stem cells: clinical implications for cancer therapy Cancer stem cells are the cause of drug resistance in multiple myeloma: fact or fiction?Hedgehog Signaling in the Maintenance of Cancer Stem Cells Lung cancer-initiating cells: a novel target for cancer therapy Cooperative integration between HEDGEHOG-GLI signalling and other oncogenic pathways: implications for cancer therapy Aberrant activation of the hedgehog signaling pathway in malignant hematological neoplasms Cancer stem cells: relevance to clinical transplantation Context-dependent signal integration by the GLI code: the oncogenic load, pathways, modifiers and implications for cancer therapy Targeting the biophysical properties of the myeloma initiating cell niches: a pharmaceutical synergism analysis using multi-scale agent-based modeling Drug resistance in multiple myeloma: latest findings and new concepts on molecular mechanisms.The Anti-Cancer Effect of Polyphenols against Breast Cancer and Cancer Stem Cells: Molecular Mechanisms In vitro models of cancer stem cells and clinical applications Molecular pathways: novel approaches for improved therapeutic targeting of Hedgehog signaling in cancer stem cells Hedgehog signaling and the Gli code in stem cells, cancer, and metastases Survival regulation of leukemia stem cells Sustained proliferation in cancer: Mechanisms and novel therapeutic targets Chemoresistance in prostate cancer cells is regulated by miRNAs and Hedgehog pathway Self-renewal of acute lymphocytic leukemia cells is limited by the Hedgehog pathway inhibitors cyclopamine and IPI-926 An overview of the role of cancer stem cells in spine tumors with a special focus on chordoma.Cancer stem cell-directed therapies: recent data from the laboratory and clinic.Recent patents for Hedgehog pathway inhibitors for the treatment of malignancy.Measurement of multiple drug resistance transporter activity in putative cancer stem/progenitor cells.Prognostic significance of tumorigenic cells with mesenchymal features in pancreatic adenocarcinoma Combined inhibition of GLI and FLT3 signaling leads to effective anti-leukemic effects in human acute myeloid leukemia.Differentiation stage of myeloma plasma cells: biological and clinical significance.Lenalidomide targets clonogenic side population in multiple myeloma: pathophysiologic and clinical implications.Evidence for self-renewing lung cancer stem cells and their implications in tumor initiation, progression, and targeted therapy.Novel systemic therapies for small cell lung cancer Cancer stem cells: a novel paradigm for cancer prevention and treatment.Internal ribosome entry site of bFGF is the target of thalidomide for IMiDs development in multiple myeloma.Implications of heterogeneity in multiple myeloma.Targeting Hedgehog--a cancer stem cell pathway ABCG2 is required to control the sonic hedgehog pathway in side population cells with stem-like properties.

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P2860

Hedgehog signaling maintains a tumor stem cell compartment in multiple myeloma.

http://www.wikidata.org/entity/Q35652021

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Hedgehog signaling maintains a tumor stem cell compartment in multiple myeloma.

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Hedgehog signaling maintains a tumor stem cell compartment in multiple myeloma.

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Hedgehog signaling maintains a tumor stem cell compartment in multiple myeloma.

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Hedgehog signaling maintains a tumor stem cell compartment in multiple myeloma.

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Hedgehog signaling maintains a tumor stem cell compartment in multiple myeloma.

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Hedgehog signaling maintains a tumor stem cell compartment in multiple myeloma.

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Proceedings of the National Academy of Sciences of the United States of America

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Hedgehog signaling maintains a tumor stem cell compartment in multiple myeloma.

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Carol A Huff

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Craig D Peacock

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D Neil Watkins

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Evan Jones

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Gregory S Gesell

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Ian M Corcoran-Schwartz

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Jonathan T Rhodes

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Jynho Kim

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Philip A Beachy

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Qiuju Wang

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P2860

Characterization of clonogenic multiple myeloma cells

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

Stem cells, cancer, and cancer stem cells

Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: implication of Gli2 and Gli3 as primary mediators of Shh signaling

The Hedgehog and Wnt signalling pathways in cancer

Sonic hedgehog induces the proliferation of primitive human hematopoietic cells via BMP regulation

Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours

A mouse model for medulloblastoma and basal cell nevus syndrome

Hedgehog signaling in animal development: paradigms and principles

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104

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