Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector - Wikidata - awgldk - TriplyDB

Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector

Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector

http://www.wikidata.org/entity/Q24631549

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Proteomic identification of Hsp70 as a new Plk1 substrate in arsenic trioxide-induced mitotically arrested cells From an old remedy to a magic bullet: molecular mechanisms underlying the therapeutic effects of arsenic in fighting leukemia Arsenic trioxide inhibits human cancer cell growth and tumor development in mice by blocking Hedgehog/GLI pathway Itraconazole and arsenic trioxide inhibit Hedgehog pathway activation and tumor growth associated with acquired resistance to smoothened antagonists Carcinogenic effects of "whole-life" exposure to inorganic arsenic in CD1 mice The hedgehog pathway in triple-negative breast cancer Targeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI Inhibitors Hedgehog Cholesterolysis: Specialized Gatekeeper to Oncogenic Signaling The Role of Hedgehog Signaling in Tumor Induced Bone Disease Hedgehog Signaling in Malignant Pleural Mesothelioma Cooperative integration between HEDGEHOG-GLI signalling and other oncogenic pathways: implications for cancer therapy Basal cell carcinoma - molecular biology and potential new therapies Darinaparsin is a multivalent chemotherapeutic which induces incomplete stress response with disruption of microtubules and Shh signaling FOXC1 Activates Smoothened-Independent Hedgehog Signaling in Basal-like Breast Cancer Survival regulation of leukemia stem cells Arsenic trioxide prevents osteosarcoma growth by inhibition of GLI transcription via DNA damage accumulation TRAIL-Based High Throughput Screening Reveals a Link between TRAIL-Mediated Apoptosis and Glutathione Reductase, a Key Component of Oxidative Stress Response DYRK1B as therapeutic target in Hedgehog/GLI-dependent cancer cells with Smoothened inhibitor resistance VMY-1-103 is a novel CDK inhibitor that disrupts chromosome organization and delays metaphase progression in medulloblastoma cells.Management of pediatric and adult patients with medulloblastoma.The role of GLI1 for 5-Fu resistance in colorectal cancer Advanced treatment for basal cell carcinomas.Arsenic trioxide inhibits EBV reactivation and promotes cell death in EBV-positive lymphoma cells.Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition.Arsenic: a potentially useful poison for Hedgehog-driven cancers.Mutant p53 protein is targeted by arsenic for degradation and plays a role in arsenic-mediated growth suppression.Gli1/DNA interaction is a druggable target for Hedgehog-dependent tumors.Combining the differentiating effect of panobinostat with the apoptotic effect of arsenic trioxide leads to significant survival benefit in a model of t(8;21) acute myeloid leukemia.The hedgehog/Gli signaling paradigm in prostate cancer Synergistic inhibition of colon carcinoma cell growth by Hedgehog-Gli1 inhibitor arsenic trioxide and phosphoinositide 3-kinase inhibitor LY294002.Neuropilins are positive regulators of Hedgehog signal transduction.Active site targeting of hedgehog precursor protein with phenylarsine oxide.Hedgehog/GLI and PI3K signaling in the initiation and maintenance of chronic lymphocytic leukemia.Hedgehog pathway as a drug target: Smoothened inhibitors in development.Targeting Notch, Hedgehog, and Wnt pathways in cancer stem cells: clinical update Targeting the Hedgehog signaling pathway in cancer: beyond Smoothened.Pharmacological GLI2 inhibition prevents myofibroblast cell-cycle progression and reduces kidney fibrosis.Identification and functional characterization of novel transcriptional enhancers involved in regulating human GLI3 expression during early development.Molecular pathways: the hedgehog signaling pathway in cancer.Hedgehog pathway inhibition and the race against tumor evolution

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P2860

Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector

http://www.wikidata.org/entity/Q24631549

description

2010 nî lūn-bûn

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2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հուլիսին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Arsenic antagonizes the Hedgeh ...... Gli2 transcriptional effector

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Arsenic antagonizes the Hedgeh ...... Gli2 transcriptional effector

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Arsenic antagonizes the Hedgeh ...... Gli2 transcriptional effector

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type

label

Arsenic antagonizes the Hedgeh ...... Gli2 transcriptional effector

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Arsenic antagonizes the Hedgeh ...... Gli2 transcriptional effector

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Arsenic antagonizes the Hedgeh ...... Gli2 transcriptional effector

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prefLabel

Arsenic antagonizes the Hedgeh ...... Gli2 transcriptional effector

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Arsenic antagonizes the Hedgeh ...... Gli2 transcriptional effector

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Arsenic antagonizes the Hedgeh ...... Gli2 transcriptional effector

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PNAS.1006822107

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Proceedings of the National Academy of Sciences of the United States of America

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Arsenic antagonizes the Hedgeh ...... Gli2 transcriptional effector

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P2093

Dale Gardner

http://www.w3.org/2001/XMLSchema#string

James Kim

http://www.w3.org/2001/XMLSchema#string

John J Lee

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Jynho Kim

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Philip A Beachy

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P2860

Activating Smoothened mutations in sporadic basal-cell carcinoma

Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome

Small molecule modulation of Smoothened activity

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists

Activation of the hedgehog pathway in advanced prostate cancer

Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma.

Vertebrate Smoothened functions at the primary cilium.

Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

Hedgehog signaling in animal development: paradigms and principles

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107

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20624968

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2922148

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