An impaired mitochondrial electron transport chain increases retention of the hypoxia imaging agent diacetylbis(4-methylthiosemicarbazonato)copperII.
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Copper delivery to the CNS by CuATSM effectively treats motor neuron disease in SOD(G93A) mice co-expressing the Copper-Chaperone-for-SODInhibition of TDP-43 accumulation by bis(thiosemicarbazonato)-copper complexes.Metformin induces an intracellular reductive state that protects oesophageal squamous cell carcinoma cells against cisplatin but not copper-bis(thiosemicarbazones).Neuroprotective copper bis(thiosemicarbazonato) complexes promote neurite elongation.Metal-deficient SOD1 in amyotrophic lateral sclerosis.Pharmacological activity of metal binding agents that alter copper bioavailability.The hypoxia imaging agent CuII(atsm) is neuroprotective and improves motor and cognitive functions in multiple animal models of Parkinson's disease.Assessment of the Tumor Redox Status in Head and Neck Cancer by 62Cu-ATSM PET.Pharmacokinetic Analysis of (64)Cu-ATSM Dynamic PET in Human Xenograft Tumors in MiceModification of intracellular glutathione status does not change the cardiac trapping of (64)Cu(ATSM)Copper as a target for prostate cancer therapeutics: copper-ionophore pharmacology and altering systemic copper distribution.CuII(atsm) improves the neurological phenotype and survival of SOD1G93A mice and selectively increases enzymatically active SOD1 in the spinal cordMitochondrial metals as a potential therapeutic target in neurodegeneration.A nuclear chocolate box: the periodic table of nuclear medicine.Heterogeneity in intratumor correlations of 18F-FDG, 18F-FLT, and 61Cu-ATSM PET in canine sinonasal tumors.Targeting copper in cancer therapy: 'Copper That Cancer'.Association between hypoxic volume and underlying hypoxia-induced gene expression in oropharyngeal squamous cell carcinoma.A dual radiolabelling approach for tracking metal complexes: investigating the speciation of copper bis(thiosemicarbazonates) in vitro and in vivo.Positron emission tomography in amyotrophic lateral sclerosis: Towards targeting of molecular pathological hallmarks.Cardioprotective effects of Cu(II)ATSM in human vascular smooth muscle cells and cardiomyocytes mediated by Nrf2 and DJ-1.Antimicrobial effects of copper(II) bis(thiosemicarbazonato) complexes provide new insight into their biochemical mode of action.Precise Evaluation of Striatal Oxidative Stress Corrected for Severity of Dopaminergic Neuronal Degeneration in Patients with Parkinson's Disease: A Study with 62Cu-ATSM PET and 123I-FP-CIT SPECT.The Copper bis(thiosemicarbazone) Complex CuII(atsm) Is Protective Against Cerebral Ischemia Through Modulation of the Inflammatory Milieu.Endogenous Cu in the central nervous system fails to satiate the elevated requirement for Cu in a mutant SOD1 mouse model of ALS.Cu(atsm) Attenuates Neuroinflammation
P2860
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P2860
An impaired mitochondrial electron transport chain increases retention of the hypoxia imaging agent diacetylbis(4-methylthiosemicarbazonato)copperII.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
An impaired mitochondrial elec ...... lthiosemicarbazonato)copperII.
@ast
An impaired mitochondrial elec ...... lthiosemicarbazonato)copperII.
@en
type
label
An impaired mitochondrial elec ...... lthiosemicarbazonato)copperII.
@ast
An impaired mitochondrial elec ...... lthiosemicarbazonato)copperII.
@en
prefLabel
An impaired mitochondrial elec ...... lthiosemicarbazonato)copperII.
@ast
An impaired mitochondrial elec ...... lthiosemicarbazonato)copperII.
@en
P2093
P2860
P50
P356
P1476
An impaired mitochondrial elec ...... ylthiosemicarbazonato)copperII
@en
P2093
Alexandra I Mot
Janine L James
Maria S Savva
Michael A Cater
Paul S Donnelly
SinChun Lim
P2860
P356
10.1073/PNAS.1116227108
P407
P577
2011-12-15T00:00:00Z