An impaired mitochondrial electron transport chain increases retention of the hypoxia imaging agent diacetylbis(4-methylthiosemicarbazonato)copperII. - Wikidata - awgldk - TriplyDB

An impaired mitochondrial electron transport chain increases retention of the hypoxia imaging agent diacetylbis(4-methylthiosemicarbazonato)copperII.

An impaired mitochondrial electron transport chain increases retention of the hypoxia imaging agent diacetylbis(4-methylthiosemicarbazonato)copperII.

http://www.wikidata.org/entity/Q35657769

about

Copper delivery to the CNS by CuATSM effectively treats motor neuron disease in SOD(G93A) mice co-expressing the Copper-Chaperone-for-SOD Inhibition of TDP-43 accumulation by bis(thiosemicarbazonato)-copper complexes.Metformin induces an intracellular reductive state that protects oesophageal squamous cell carcinoma cells against cisplatin but not copper-bis(thiosemicarbazones).Neuroprotective copper bis(thiosemicarbazonato) complexes promote neurite elongation.Metal-deficient SOD1 in amyotrophic lateral sclerosis.Pharmacological activity of metal binding agents that alter copper bioavailability.The hypoxia imaging agent CuII(atsm) is neuroprotective and improves motor and cognitive functions in multiple animal models of Parkinson's disease.Assessment of the Tumor Redox Status in Head and Neck Cancer by 62Cu-ATSM PET.Pharmacokinetic Analysis of (64)Cu-ATSM Dynamic PET in Human Xenograft Tumors in Mice Modification of intracellular glutathione status does not change the cardiac trapping of (64)Cu(ATSM)Copper as a target for prostate cancer therapeutics: copper-ionophore pharmacology and altering systemic copper distribution.CuII(atsm) improves the neurological phenotype and survival of SOD1G93A mice and selectively increases enzymatically active SOD1 in the spinal cord Mitochondrial metals as a potential therapeutic target in neurodegeneration.A nuclear chocolate box: the periodic table of nuclear medicine.Heterogeneity in intratumor correlations of 18F-FDG, 18F-FLT, and 61Cu-ATSM PET in canine sinonasal tumors.Targeting copper in cancer therapy: 'Copper That Cancer'.Association between hypoxic volume and underlying hypoxia-induced gene expression in oropharyngeal squamous cell carcinoma.A dual radiolabelling approach for tracking metal complexes: investigating the speciation of copper bis(thiosemicarbazonates) in vitro and in vivo.Positron emission tomography in amyotrophic lateral sclerosis: Towards targeting of molecular pathological hallmarks.Cardioprotective effects of Cu(II)ATSM in human vascular smooth muscle cells and cardiomyocytes mediated by Nrf2 and DJ-1.Antimicrobial effects of copper(II) bis(thiosemicarbazonato) complexes provide new insight into their biochemical mode of action.Precise Evaluation of Striatal Oxidative Stress Corrected for Severity of Dopaminergic Neuronal Degeneration in Patients with Parkinson's Disease: A Study with 62Cu-ATSM PET and 123I-FP-CIT SPECT.The Copper bis(thiosemicarbazone) Complex CuII(atsm) Is Protective Against Cerebral Ischemia Through Modulation of the Inflammatory Milieu.Endogenous Cu in the central nervous system fails to satiate the elevated requirement for Cu in a mutant SOD1 mouse model of ALS.Cu(atsm) Attenuates Neuroinflammation

P2860

Q28272734-BE274815-B109-464B-8DB4-BD2A57592FCD Q31082029-9C04C590-772C-45D6-A332-170EB6B4D21B Q33610569-EFB3194F-7DD0-4D08-BCA8-7B109E2E9FAB Q35108628-7952ACDA-99AA-4EFF-8F98-F01FE042A051 Q35533798-3F51E274-87E5-4287-8AD1-BE11BC52B994 Q35587484-10B91C6F-839C-457C-BC21-ACA939916DD6 Q35894167-D9A6D26A-B237-48EE-AFDC-E9D49681F7CD Q36020018-F3F8B7D0-BC4F-4E23-8032-2D5FCE80ABB9 Q36335266-FD4169AC-1ACE-4FFB-BA41-6ECED30694D6 Q36944378-781AF2EE-E537-4FF8-A0A5-FA60350A9237 Q37392908-87FB6DD6-D973-4F95-8D8D-2052E5CE6C47 Q37638093-30ED3E53-B805-41E8-B6B7-5340FEC87FC8 Q37686294-A45142F4-72CE-42CA-942D-C99BE9DBD814 Q38269216-F620EC0A-CBC9-44A0-9613-A70830A926A3 Q38424458-9A7186D2-78C9-4957-95E0-3B50F24AC2F7 Q38575035-1A368BB9-67D0-4D7B-82D4-F888857B334A Q38889339-E94354D8-67A5-40EF-A88A-4F639ACBCE4D Q38900380-0304DBA7-9ACF-43D5-A5E3-C36A4F1F4A32 Q39033807-0791BED6-7B3B-4954-B5C3-F1982B9A5535 Q42099970-84BBC749-5773-4F30-8C83-793F5ABE2039 Q42232549-ACCC6C37-287C-4DDD-8B73-0F18D3C06591 Q47722876-97DDE370-304D-438A-A223-218328CFB732 Q47838090-47A5E1C7-1AB2-4D26-B945-ECAF746405CB Q48649269-9D84283E-9D2B-4632-A802-32130F5B65E7 Q57492442-BA0DC384-F0BD-433E-B6C9-0012EEA9F356

P2860

An impaired mitochondrial electron transport chain increases retention of the hypoxia imaging agent diacetylbis(4-methylthiosemicarbazonato)copperII.

http://www.wikidata.org/entity/Q35657769

description

2011 nî lūn-bûn

@nan

2011年の論文

@ja

2011年論文

@yue

2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

@zh-mo

2011年論文

@zh-tw

2011年论文

@wuu

2011年论文

@zh

2011年论文

@zh-cn

name

An impaired mitochondrial elec ...... lthiosemicarbazonato)copperII.

@ast

An impaired mitochondrial elec ...... lthiosemicarbazonato)copperII.

@en

type

label

An impaired mitochondrial elec ...... lthiosemicarbazonato)copperII.

@ast

An impaired mitochondrial elec ...... lthiosemicarbazonato)copperII.

@en

prefLabel

An impaired mitochondrial elec ...... lthiosemicarbazonato)copperII.

@ast

An impaired mitochondrial elec ...... lthiosemicarbazonato)copperII.

@en

P1433

Q35657769-6EB720B3-2828-42BE-B6B1-851614C50D01

P1476

Q35657769-430781A9-B7AF-49F9-85E9-EDDBEE9F5604

P2093

Q35657769-248C1D6C-261B-4872-B4C9-A1CDD3DCDD9E

Q35657769-2F755A4F-FE8D-40D5-90E5-D137EAAF693D

Q35657769-3A6DF243-C273-418C-A693-5CC2F08FFAFD

Q35657769-A138AC64-9A41-46BD-B02F-5C195DB988C2

Q35657769-C8B6F423-B46F-48B6-964B-2378B8E36FA7

Q35657769-CD3C03E1-5EE7-4AF6-A9AF-C484A48CAB51

P2860

Q35657769-02E72580-4D5D-4480-A9BE-421197E1BF13

Q35657769-09E31253-B33A-466A-8BAF-2D3B8A50C572

Q35657769-0CF1C0C9-6BF9-4A8A-B63F-CF195A8EEB4E

Q35657769-0E409AF0-FFA3-439A-887F-B5E290FBFC88

Q35657769-18E30C13-583A-44F9-8B30-5DE28F7CBEF7

Q35657769-2A6D82EF-D313-4CFF-81B7-F1D2BF0B9EC1

Q35657769-31364265-064A-4BEB-BA13-CA0EC03F799C

Q35657769-31BD9088-BF3B-4D93-8EA3-8C913AA04451

Q35657769-3B482881-4733-4850-A0F3-1CF961895A81

Q35657769-3C894C03-2965-4298-9100-74ED078651E6

P304

Q35657769-AA36D150-D4D8-44F3-B4A0-696C36A08CE9

P31

Q35657769-490C8275-2E73-47F5-BCC7-7A2BE6A72778

P356

Q35657769-E0DA281B-9E75-42A5-8311-44C659D16E90

P407

Q35657769-240803DC-5A90-4CAD-AC00-5BCC1C7F6D63

P433

Q35657769-9093ACF5-E228-41CC-B199-7B71FA7E8A4E

P478

Q35657769-740AF723-20BE-4C6F-A753-11DA85E20DAB

P50

Q35657769-7EF88E75-BEC9-4F1D-B196-31C13C75332C

Q35657769-81A95021-88BD-4CDB-9938-265CE4DD3765

Q35657769-B6F6D0A5-F228-44D1-958B-B8C4CD705336

Q35657769-BCDBCB54-C441-4234-82F4-A2006A982C0B

Q35657769-E48B3F1C-C459-4BF2-B662-10833DBCEC30

P577

Q35657769-BE76F052-9EF0-4403-945D-71B1B059B86E

P5875

Q35657769-A316815F-FC1B-460D-B0AC-42A7219173A5

P698

Q35657769-2DC6AA4D-91B2-4AED-9B29-ED7D54DBA036

P921

Q35657769-325797EA-1199-49B3-83AC-29C14927EABF

P932

Q35657769-B37F0521-624E-470D-9243-932B922BE619

P356

PNAS.1116227108

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

An impaired mitochondrial elec ...... ylthiosemicarbazonato)copperII

@en

P2093

Alexandra I Mot

http://www.w3.org/2001/XMLSchema#string

Janine L James

http://www.w3.org/2001/XMLSchema#string

Maria S Savva

http://www.w3.org/2001/XMLSchema#string

Michael A Cater

http://www.w3.org/2001/XMLSchema#string

Paul S Donnelly

http://www.w3.org/2001/XMLSchema#string

SinChun Lim

http://www.w3.org/2001/XMLSchema#string

P2860

Human copper transporter 2 is localized in late endosomes and lysosomes and facilitates cellular copper uptake

Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine)

An unusual dimeric structure of a Cu(I) bis(thiosemicarbazone) complex: implications for the mechanism of hypoxic selectivity of the Cu(II) derivatives.

Cloning of neuronal mtDNA variants in cultured cells by synaptosome fusion with mtDNA-less cells.

Functions of zinc in signaling, proliferation and differentiation of mammalian cells.

Clusterin (apolipoprotein J), a molecular chaperone that facilitates degradation of the copper-ATPases ATP7A and ATP7B.

Regulation of metallothionein genes by heavy metals appears to be mediated by a zinc-sensitive inhibitor that interacts with a constitutively active transcription factor, MTF-1

In vitro and in vivo evaluation of bifunctional bisthiosemicarbazone 64Cu-complexes for the positron emission tomography imaging of hypoxia.

Mitochondrial respiratory chain and free radical generation in stroke.

Cybrid models of mtDNA disease and transmission, from cells to mice.

P304

47-52

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1073/PNAS.1116227108

http://www.w3.org/2001/XMLSchema#string

P407

P433

1

http://www.w3.org/2001/XMLSchema#string

P478

109

http://www.w3.org/2001/XMLSchema#string

P50

Anthony R. White

Peter J. Crouch

Jeffrey R Liddell

Brett M Paterson

P577

2011-12-15T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

51883611

http://www.w3.org/2001/XMLSchema#string

P698

22173633

http://www.w3.org/2001/XMLSchema#string

P921

P932

3252939

http://www.w3.org/2001/XMLSchema#string