Human IgG2 antibodies display disulfide-mediated structural isoforms.
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Charge variants in IgG1: Isolation, characterization, in vitro binding properties and pharmacokinetics in ratsPosttranslational Modifications and the Immunogenicity of BiotherapeuticsInfluence of immunoglobulin isotype on therapeutic antibody functionDisulfide bond structures of IgG molecules: structural variations, chemical modifications and possible impacts to stability and biological functionStability engineering of the human antibody repertoireIn vitro and in vivo modifications of recombinant and human IgG antibodiesThe effect of tensile stress on the conformational free energy landscape of disulfide bondsEnhancing Protein Disulfide Bond Cleavage by UV Excitation and Electron Capture Dissociation for Top-Down Mass SpectrometryFully recombinant IgG2a Fc multimers (stradomers) effectively treat collagen-induced arthritis and prevent idiopathic thrombocytopenic purpura in miceProduction of IgG antibodies to pneumococcal polysaccharides is associated with expansion of ICOS+ circulating memory T follicular-helper cells which is impaired by HIV infection.Antiviral Functions of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific IgG Antibodies: Effects of Antiretroviral Therapy and Implications for Therapeutic HIV-1 Vaccine Design.Disulphide bond reduction of a therapeutic monoclonal antibody during cell culture manufacturing operationsRemoval of a C-terminal serine residue proximal to the inter-chain disulfide bond of a human IgG1 lambda light chain mediates enhanced antibody stability and antibody dependent cell-mediated cytotoxicityOn the perplexingly low rate of transport of IgG2 across the human placenta.IgG subclasses and allotypes: from structure to effector functions.Structural and functional characterization of the trifunctional antibody catumaxomabProtected hinge in the immunoglobulin G2-A2 disulfide isoformThree-dimensional structure of the human myeloma IgG2.Conformation of the human immunoglobulin G2 hinge imparts superagonistic properties to immunostimulatory anticancer antibodies.Advanced mass spectrometry workflows for analyzing disulfide bonds in biologics.Viremic HIV Controllers Exhibit High Plasmacytoid Dendritic Cell-Reactive Opsonophagocytic IgG Antibody Responses against HIV-1 p24 Associated with Greater Antibody Isotype Diversification.A review of the efficacy and safety of denosumab in postmenopausal women with osteoporosis.Alleviating nonlinear behavior of disulfide isoforms in the reversed-phase liquid chromatography of IgG2.PDADMAC flocculation of Chinese hamster ovary cells: enabling a centrifuge-less harvest process for monoclonal antibodies.Chromatographic analysis of the acidic and basic species of recombinant monoclonal antibodies.Complementary MS methods assist conformational characterization of antibodies with altered S-S bonding networks.Effects of subclass change on the structural stability of chimeric, humanized, and human antibodies under thermal stress.Developability studies before initiation of process development: improving manufacturability of monoclonal antibodies.Stability of IgG isotypes in serum.Cysteine tagging for MS-based proteomics.Post-translational structural modifications of immunoglobulin G and their effect on biological activity.Using the Lessons Learned From the Clinic to Improve the Preclinical Development of Antibody Drug ConjugatesThe multiple facets of FcRn in immunity.Direct observation of disulfide isomerization in a single protein.Impact of cell culture on recombinant monoclonal antibody product heterogeneity.Assessment of disulfide and hinge modifications in monoclonal antibodiesHuman Fc receptor-like 5 binds intact IgG via mechanisms distinct from those of Fc receptors.Comparative study of the three different fluorophore antibody conjugation strategies.The in vitro resistance of IgG2 to proteolytic attack concurs with a comparative paucity of autoantibodies against peptide analogs of the IgG2 hinge.Relative stabilities of IgG1 and IgG4 Fab domains: influence of the light-heavy interchain disulfide bond architecture
P2860
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P2860
Human IgG2 antibodies display disulfide-mediated structural isoforms.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Human IgG2 antibodies display disulfide-mediated structural isoforms.
@ast
Human IgG2 antibodies display disulfide-mediated structural isoforms.
@en
type
label
Human IgG2 antibodies display disulfide-mediated structural isoforms.
@ast
Human IgG2 antibodies display disulfide-mediated structural isoforms.
@en
prefLabel
Human IgG2 antibodies display disulfide-mediated structural isoforms.
@ast
Human IgG2 antibodies display disulfide-mediated structural isoforms.
@en
P2093
P2860
P356
P1476
Human IgG2 antibodies display disulfide-mediated structural isoforms.
@en
P2093
Alain Balland
Drew N Kelner
Gregory C Flynn
Jette Wypych
Margaret Speed Ricci
Martin J Allen
Pavel V Bondarenko
Szilan Fodor
P2860
P304
16194-16205
P356
10.1074/JBC.M709987200
P407
P577
2008-03-13T00:00:00Z