The in vitro resistance of IgG2 to proteolytic attack concurs with a comparative paucity of autoantibodies against peptide analogs of the IgG2 hinge.
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Comparability of a three-dimensional structure in biopharmaceuticals using spectroscopic methods.Anti-Hinge Antibodies Recognize IgG Subclass- and Protease-Restricted Neoepitopes.Pharmacokinetics and pharmacodynamics of recombinant human EPO-Fc fusion protein in vivoCleavage of IgG1 in gingival crevicular fluid is associated with the presence of Porphyromonas gingivalisAn Fc engineering approach that modulates antibody-dependent cytokine release without altering cell-killing functions.A monoclonal antibody against hinge-cleaved IgG restores effector function to proteolytically-inactivated IgGs in vitro and in vivo.Engineered protease-resistant antibodies with selectable cell-killing functions.Evading pre-existing anti-hinge antibody binding by hinge engineering.Molecular characterization of human anti-hinge antibodies derived from single cell cloning of normal human B cells.Toxicological and pharmacological assessment of AGEN1884, a novel human IgG1 anti-CTLA-4 antibody.
P2860
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P2860
The in vitro resistance of IgG2 to proteolytic attack concurs with a comparative paucity of autoantibodies against peptide analogs of the IgG2 hinge.
description
2011 nî lūn-bûn
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2011年の論文
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2011年学术文章
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2011年学术文章
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2011年学术文章
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2011年学术文章
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2011年学术文章
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2011年學術文章
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2011年學術文章
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2011年學術文章
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name
The in vitro resistance of IgG ...... ide analogs of the IgG2 hinge.
@en
The in vitro resistance of IgG ...... ide analogs of the IgG2 hinge.
@nl
type
label
The in vitro resistance of IgG ...... ide analogs of the IgG2 hinge.
@en
The in vitro resistance of IgG ...... ide analogs of the IgG2 hinge.
@nl
prefLabel
The in vitro resistance of IgG ...... ide analogs of the IgG2 hinge.
@en
The in vitro resistance of IgG ...... ide analogs of the IgG2 hinge.
@nl
P2093
P2860
P356
P1476
The in vitro resistance of IgG ...... ide analogs of the IgG2 hinge.
@en
P2093
Allison Oberholtzer
Brandy Strake
Robert E Jordan
P2860
P304
P356
10.4161/MABS.3.6.18119
P577
2011-11-01T00:00:00Z