Filamin B deficiency in mice results in skeletal malformations and impaired microvascular development
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Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from ScandinaviaStructure of three tandem filamin domains reveals auto-inhibition of ligand bindingCommon variants in FLNB/CRTAP, not ARHGEF3 at 3p, are associated with osteoporosis in southern Chinese womenEpidemiology and pathophysiology of mitral valve prolapse: new insights into disease progression, genetics, and molecular basisEvidence for the mechanosensor function of filamin in tissue development.Filamin and phospholipase C-ε are required for calcium signaling in the Caenorhabditis elegans spermathecaFilamins regulate cell spreading and initiation of cell migrationMolecular Basis of Filamin A-FilGAP Interaction and Its Impairment in Congenital Disorders Associated with Filamin A MutationsAtomic Structures of Two Novel Immunoglobulin-like Domain Pairs in the Actin Cross-linking Protein FilaminFilamin B mutations cause chondrocyte defects in skeletal developmentF-actin clustering and cell dysmotility induced by the pathological W148R missense mutation of filamin B at the actin-binding domainFLN-1/filamin is required for maintenance of actin and exit of fertilized oocytes from the spermatheca in C. elegansTranscript diversification in the nervous system: a to I RNA editing in CNS function and disease developmentFilamin B plays a key role in vascular endothelial growth factor-induced endothelial cell motility through its interaction with Rac-1 and Vav-2.Extended Field Laser Confocal Microscopy (EFLCM): combining automated Gigapixel image capture with in silico virtual microscopyGene expression profiles of colonic mucosa in healthy young adult and senior dogs.Filamins in mechanosensing and signaling.Formin 1 and filamin B physically interact to coordinate chondrocyte proliferation and differentiation in the growth plateDisease-associated mutations in the actin-binding domain of filamin B cause cytoplasmic focal accumulations correlating with disease severity.Targeting filamin B induces tumor growth and metastasis via enhanced activity of matrix metalloproteinase-9 and secretion of VEGF-A.High-molecular-weight hyaluronan is a novel inhibitor of pulmonary vascular leakinessThe filamins: organizers of cell structure and functionConditional testing of multiple variants associated with bone mineral density in the FLNB gene region suggests that they represent a single association signal.Filamin-A regulates neutrophil uropod retraction through RhoA during chemotaxis.Filamin B regulates chondrocyte proliferation and differentiation through Cdk1 signalingType XVII collagen regulates lamellipod stability, cell motility, and signaling to Rac1 by targeting bullous pemphigoid antigen 1e to alpha6beta4 integrinAssembly of a filamin four-domain fragment and the influence of splicing variant-1 on the structure.Filamin depletion blocks endoplasmic spreading and destabilizes force-bearing adhesions.Phenotype and genotype in patients with Larsen syndrome: clinical homogeneity and allelic heterogeneity in seven patientsCritical role of filamin-binding LIM protein 1 (FBLP-1)/migfilin in regulation of bone remodeling.Targeting filamin A reduces K-RAS-induced lung adenocarcinomas and endothelial response to tumor growth in mice.Hypoxia-induced expression of VE-cadherin and filamin B in glioma cell cultures and pseudopalisade structuresAuxiliary and autonomous proteoglycan signaling networksDisruption of the Flnb gene in mice phenocopies the human disease spondylocarpotarsal synostosis syndromeCell biology of embryonic migration.Animal models of scoliosis.Snail promotes cell migration through PI3K/AKT-dependent Rac1 activation as well as PI3K/AKT-independent pathways during prostate cancer progression.Characterization of two ENU-induced mutations affecting mouse skeletal morphology.Cyclosporine does not reduce myocardial infarct size in a porcine ischemia-reperfusion model.Protein disulfide isomerase increases in myocardial endothelial cells in mice exposed to chronic hypoxia: a stimulatory role in angiogenesis.
P2860
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P2860
Filamin B deficiency in mice results in skeletal malformations and impaired microvascular development
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Filamin B deficiency in mice r ...... ired microvascular development
@ast
Filamin B deficiency in mice r ...... ired microvascular development
@en
type
label
Filamin B deficiency in mice r ...... ired microvascular development
@ast
Filamin B deficiency in mice r ...... ired microvascular development
@en
prefLabel
Filamin B deficiency in mice r ...... ired microvascular development
@ast
Filamin B deficiency in mice r ...... ired microvascular development
@en
P2093
P2860
P50
P356
P1476
Filamin B deficiency in mice r ...... ired microvascular development
@en
P2093
Emilie Flaberg
Johan Sandzén
Levent M Akyürek
Martin O Bergo
Renhai Cao
Xianghua Zhou
P2860
P304
P356
10.1073/PNAS.0608360104
P407
P577
2007-02-26T00:00:00Z