Chemical cross-linking provides a model of the gamma-secretase complex subunit architecture and evidence for close proximity of the C-terminal fragment of presenilin with APH-1.
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Cellular mechanisms of γ-secretase substrate selection, processing and toxicityToward the structure of presenilin/γ-secretase and presenilin homologsThree-dimensional structure of human γ-secretaseAph-1 associates directly with full-length and C-terminal fragments of gamma-secretase substratesStructural basis of human γ-secretase assembly.Pharmacological analysis of Drosophila melanogaster gamma-secretase with respect to differential proteolysis of Notch and APP.Specific domains in anterior pharynx-defective 1 determine its intramembrane interactions with nicastrin and presenilin.Inhibitors of γ-secretase stabilize the complex and differentially affect processing of amyloid precursor protein and other substrates.Presenilins and γ-secretase: structure, function, and role in Alzheimer Disease.Toward structural elucidation of the gamma-secretase complex.Borrelia burgdorferi small lipoprotein Lp6.6 is a member of multiple protein complexes in the outer membrane and facilitates pathogen transmission from ticks to mice.Induced dimerization of the amyloid precursor protein leads to decreased amyloid-beta protein production.The very many faces of presenilins and the γ-secretase complex.Biological function of Presenilin and its role in AD pathogenesisContribution of the γ-secretase subunits to the formation of catalytic pore of presenilin 1 protein.Soluble amyloid precursor protein induces rapid neural differentiation of human embryonic stem cells.Bioinformatics identification of modules of transcription factor binding sites in Alzheimer's disease-related genes by in silico promoter analysis and microarrays.Alterations in phosphatidylethanolamine levels affect the generation of Aβ.Reduction of Aβ Generation by Schisandrin B through Restraining Beta-Secretase 1 Transcription and Translation.
P2860
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P2860
Chemical cross-linking provides a model of the gamma-secretase complex subunit architecture and evidence for close proximity of the C-terminal fragment of presenilin with APH-1.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Chemical cross-linking provide ...... ment of presenilin with APH-1.
@ast
Chemical cross-linking provide ...... ment of presenilin with APH-1.
@en
type
label
Chemical cross-linking provide ...... ment of presenilin with APH-1.
@ast
Chemical cross-linking provide ...... ment of presenilin with APH-1.
@en
prefLabel
Chemical cross-linking provide ...... ment of presenilin with APH-1.
@ast
Chemical cross-linking provide ...... ment of presenilin with APH-1.
@en
P2860
P356
P1476
Chemical cross-linking provide ...... ment of presenilin with APH-1.
@en
P2093
Edith Winkler
Harald Steiner
P2860
P304
34677-34686
P356
10.1074/JBC.M709067200
P407
P577
2008-09-18T00:00:00Z