Isolation of intrinsically active (MEK-independent) variants of the ERK family of mitogen-activated protein (MAP) kinases
about
The yeast Hot1 transcription factor is critical for activating a single target gene, STL1Copper is required for oncogenic BRAF signalling and tumorigenesisErk2 phosphorylation of Drp1 promotes mitochondrial fission and MAPK-driven tumor growth.SSeCKS/Gravin/AKAP12 inhibits cancer cell invasiveness and chemotaxis by suppressing a protein kinase C- Raf/MEK/ERK pathway.Importance of domain closure for the autoactivation of ERK2.Computational insights for the discovery of non-ATP competitive inhibitors of MAP kinasesPRO40 is a scaffold protein of the cell wall integrity pathway, linking the MAP kinase module to the upstream activator protein kinase C.The p38β mitogen-activated protein kinase possesses an intrinsic autophosphorylation activity, generated by a short region composed of the α-G helix and MAPK insert.The MAP kinase phosphatase MKP-1 regulates BDNF-induced axon branching.Osmostress induces autophosphorylation of Hog1 via a C-terminal regulatory region that is conserved in p38αActive ERK2 is sufficient to mediate growth arrest and differentiation signalingA novel role for copper in Ras/mitogen-activated protein kinase signaling.High-Throughput In Vitro Identification of Direct MAPK/Erk Substrates.Epithelial-mesenchymal transition and fibrosis are mutually exclusive reponses in shear-activated proximal tubular epithelial cells.Erk signaling is indispensable for genomic stability and self-renewal of mouse embryonic stem cells.Intrinsically active variants of Erk oncogenically transform cells and disclose unexpected autophosphorylation capability that is independent of TEY phosphorylationTighter αC-helix-αL16-helix interactions seem to make p38α less prone to activation by autophosphorylation than Hog1.ERK2 phosphorylates Krüppel-like factor 8 protein at serine 48 to maintain its stability.Variants of the yeast MAPK Mpk1 are fully functional independently of activation loop phosphorylation.Phenotypic Characterization of a Comprehensive Set of MAPK1/ERK2 Missense Mutants.Signaling pathways and posttranslational modifications of tau in Alzheimer's disease: the humanization of yeast cells.DEF pocket in p38α facilitates substrate selectivity and mediates autophosphorylation.Integrating proteomics with electrochemistry for identifying kinase biomarkers.Isolation and Characterization of Intrinsically Active (MEK-Independent) Mutants of Mpk1/Erk.Overexpression of Tpl2 is linked to imatinib resistance and activation of MEK-ERK and NF-κB pathways in a model of chronic myeloid leukemia.
P2860
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P2860
Isolation of intrinsically active (MEK-independent) variants of the ERK family of mitogen-activated protein (MAP) kinases
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Isolation of intrinsically act ...... ctivated protein (MAP) kinases
@ast
Isolation of intrinsically act ...... ctivated protein (MAP) kinases
@en
type
label
Isolation of intrinsically act ...... ctivated protein (MAP) kinases
@ast
Isolation of intrinsically act ...... ctivated protein (MAP) kinases
@en
prefLabel
Isolation of intrinsically act ...... ctivated protein (MAP) kinases
@ast
Isolation of intrinsically act ...... ctivated protein (MAP) kinases
@en
P2093
P2860
P356
P1476
Isolation of intrinsically act ...... ctivated protein (MAP) kinases
@en
P2093
David Engelberg
Konstantin Kogan
Natalie G Ahn
Oded Livnah
Vered Levin-Salomon
P2860
P304
34500-34510
P356
10.1074/JBC.M806443200
P407
P577
2008-10-01T00:00:00Z