Caspase-2 deficiency enhances aging-related traits in mice
about
No death without life: vital functions of apoptotic effectorsCaspase-2: killer, savior and safeguard--emerging versatile roles for an ill-defined caspaseThe enigma of caspase-2: the laymen's viewCaspase-2 as a tumour suppressorOld, new and emerging functions of caspases.Synergistic effects of apigenin and paclitaxel on apoptosis of cancer cellsReduced lipoapoptosis, hedgehog pathway activation and fibrosis in caspase-2 deficient mice with non-alcoholic steatohepatitis.Caspase-2-mediated cell death is required for deleting aneuploid cells.Caspase-2 mediated apoptotic and necrotic murine macrophage cell death induced by rough Brucella abortusCaspase-2 promotes obesity, the metabolic syndrome and nonalcoholic fatty liver disease.A nonapoptotic role for CASP2/caspase 2: modulation of autophagy.Putative functions of caspase-2.Loss of caspase-2-dependent apoptosis induces autophagy after mitochondrial oxidative stress in primary cultures of young adult cortical neurons.A knockout of the caspase 2 gene produces increased resistance of the nigrostriatal dopaminergic pathway to MPTP-induced toxicity.Fatty acid synthase inhibition engages a novel caspase-2 regulatory mechanism to induce ovarian cancer cell death.Caspase-2 maintains bone homeostasis by inducing apoptosis of oxidatively-damaged osteoclasts.Signaling pathway activation drift during aging: Hutchinson-Gilford Progeria Syndrome fibroblasts are comparable to normal middle-age and old-age cellsImpaired antioxidant defence and accumulation of oxidative stress in caspase-2-deficient miceCaspase-2 deficiency promotes aberrant DNA-damage response and genetic instability.Age-related proteostasis and metabolic alterations in Caspase-2-deficient miceInvolvement of oxidative stress and caspase 2-mediated intrinsic pathway signaling in age-related increase in muscle cell apoptosis in mice.Caspase-2 and the oxidative stress responseHow does proliferative homeostasis change with age? What causes it and how does it contribute to aging?Sex-specific alterations in glucose homeostasis and metabolic parameters during ageing of caspase-2-deficient miceThe role of caspase-2 in stress-induced apoptosis.Loss of caspase-2 augments lymphomagenesis and enhances genomic instability in Atm-deficient mice.Impaired haematopoietic stem cell differentiation and enhanced skewing towards myeloid progenitors in aged caspase-2-deficient mice.Analysis of the minimal specificity of caspase-2 and identification of Ac-VDTTD-AFC as a caspase-2-selective peptide substrate.Caspase-2: the orphan caspase.Caspase-2: the reinvented enzyme.Insights into a Critical Role of the FOXO3a-FOXM1 Axis in DNA Damage Response and Genotoxic Drug Resistance.Caspase-2 is required for DNA damage-induced expression of the CDK inhibitor p21(WAF1/CIP1)Degradomics reveals that cleavage specificity profiles of caspase-2 and effector caspases are alike.Loss of caspase-2 accelerates age-dependent alterations in mitochondrial production of reactive oxygen speciesCaspase-2 protects against oxidative stress in vivo.Caspase-2 deficiency enhances whole-body carbohydrate utilisation and prevents high-fat diet-induced obesity.Fat, sex and caspase-2.Molecular Cell Biology of Apoptosis and Necroptosis in Cancer.A Reassessment of Genes Modulating Aging in Mice Using Demographic Measurements of the Rate of Aging.Homozygous null variant in CRADD, encoding an adaptor protein that mediates apoptosis, is associated with lissencephaly.
P2860
Q24319057-CE74BE57-7FDD-4AC7-9C68-9876B8A3468FQ24595616-D7949000-3C8F-4301-A779-7BDE1C2C10E6Q24595653-0B255DAF-75C1-419B-8FA8-3AA3A4B3E5CDQ26863078-181ABF44-22D8-4D72-9757-03AD6A661788Q27686885-D1B852DF-8BCE-43A1-B7E9-AC4D52CC97A2Q28478529-3F842FD3-68EB-4218-A9A8-C316CEDC3878Q30365017-0DE87ED2-59A5-4228-ACBB-6739CD249DE1Q30853031-8B5912F4-E772-4DD2-B8AF-184EC2F58A2EQ33497936-52BBC44E-9A44-4EA3-9C1C-41974B78F50BQ33586821-1A38CC57-F9F0-4018-B5E9-5F42FB85DF00Q33878933-4263C2A9-01FB-47DB-A6A5-97A3DBF9EF38Q34167263-364C2E15-D64E-4116-81FD-4578736387A4Q34624467-391F9D15-0BC9-40CE-AFED-0CA481A6FD87Q35000544-7A299CAE-BA59-4AA4-AA17-50CF86C77A15Q35122562-CA7A3F21-9FA5-48C7-806B-4F5F0481FC0FQ35137731-D67AE138-B841-4027-B2D4-36FCC7055B7BQ35149536-C385A1D6-1F5B-46F2-91A0-7804AF71BB49Q36084482-0BEFD6FF-A11A-4A2B-894F-B72B302EE0BEQ36084491-CB1C187E-8B2F-4967-9C60-B1B498D1DB4AQ36347148-8E9FA635-3D98-4BC5-A154-A30C213B55D1Q36519843-07A8B501-CDB7-4AC0-92CA-ADAB7D74375FQ36997952-893A2165-0B54-45BA-A840-1F6D2F54A194Q37126614-EB407A4F-2E89-4C4A-84AB-56E62481EA74Q37164364-CE6C7A0C-0AA4-4C3E-ACA3-23A8A94A3996Q37310573-F17D3285-5D5C-4EE2-9EF0-603D9EB295DDQ37377477-44996E27-668A-43A4-956D-4D463A4301A9Q37603451-B7DA1682-3721-4FF4-A0F2-1D9846C5CC16Q37663650-C838BEAE-4BA7-47CD-832A-5638905086F2Q37954996-C4D6AA4E-66BE-4228-9F78-3B8E4B9EF530Q38216592-C0283C0E-4F1C-4A54-89BB-3BBAE2594365Q38270775-2DF9EF5A-CC62-4870-A5BF-6B7907E3E48AQ38392110-D48C732E-AC6F-4385-9E23-FF57B814A293Q39309276-0942A768-3165-4420-87AD-945448483290Q40808974-6BBB5203-5782-48DB-9B56-5DCE2474082DQ41660052-44572A70-82DD-44DA-A47C-2D8FF7578361Q42517446-FF93709B-8391-47B4-A78F-668DDE5DD119Q42912934-57D996B5-2431-401D-AA18-9F1D75FF0236Q50221065-75E90630-F0C8-460C-B23D-0FBF78CD888DQ51769143-56D62AE9-D51E-4834-9C63-4E5404C98392Q52089571-EFC2F5A8-99FE-4CB4-9197-2504390F1402
P2860
Caspase-2 deficiency enhances aging-related traits in mice
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Caspase-2 deficiency enhances aging-related traits in mice
@ast
Caspase-2 deficiency enhances aging-related traits in mice
@en
type
label
Caspase-2 deficiency enhances aging-related traits in mice
@ast
Caspase-2 deficiency enhances aging-related traits in mice
@en
prefLabel
Caspase-2 deficiency enhances aging-related traits in mice
@ast
Caspase-2 deficiency enhances aging-related traits in mice
@en
P2093
P2860
P1476
Caspase-2 deficiency enhances aging-related traits in mice
@en
P2093
Arlan Richardson
Asish R Chaudhuri
Barry Grubbs
Beth A Goins
Brian Herman
Eric De Waal
Gregory R Mundy
Susan S Padalecki
Yingpei Zhang
Yuji Ikeno
P2860
P304
P356
10.1016/J.MAD.2006.11.030
P577
2006-12-22T00:00:00Z