Mutations in the tumor suppressors Smad2 and Smad4 inactivate transforming growth factor beta signaling by targeting Smads to the ubiquitin-proteasome pathway
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SMAD6 contributes to patient survival in non-small cell lung cancer and its knockdown reestablishes TGF-beta homeostasis in lung cancer cellsJab1 antagonizes TGF-beta signaling by inducing Smad4 degradationLigand-dependent degradation of Smad3 by a ubiquitin ligase complex of ROC1 and associated proteinsThe role of N-glycans in colorectal cancer progression: potential biomarkers and therapeutic applicationsActivation of transforming growth factor-beta signaling by SUMO-1 modification of tumor suppressor Smad4/DPC4Expression of RALT, a feedback inhibitor of ErbB receptors, is subjected to an integrated transcriptional and post-translational controlPathogenesis of colorectal carcinoma and therapeutic implications: the roles of the ubiquitin-proteasome system and Cox-2Bone morphogenetic protein (BMP)-2 induces apoptosis in human myeloma cellsPoint mutations in the tumor suppressor Smad4/DPC4 enhance its phosphorylation by GSK3 and reversibly inactivate TGF-β signalingSmad4-expression is decreased in breast cancer tissues: a retrospective study.Computational identification of hepatitis C virus associated microRNA-mRNA regulatory modules in human livers.SMAD4 mutations in colorectal cancer probably occur before chromosomal instability, but after divergence of the microsatellite instability pathwayModulation of transforming growth factor beta (TGFbeta)/Smad transcriptional responses through targeted degradation of TGFbeta-inducible early gene-1 by human seven in absentia homologue.Role of transforming growth factor beta in cancer.Sumoylation of Smad4, the common Smad mediator of transforming growth factor-beta family signaling.Mutations at a single codon in Mad homology 2 domain of SMAD4 cause Myhre syndrome.Novel robust biomarkers for human bladder cancer based on activation of intracellular signaling pathways.Defective nucleolar localization and dominant interfering properties of a parafibromin L95P missense mutant causing the hyperparathyroidism-jaw tumor syndrome.Ubiquitin-dependent regulation of TGFbeta signaling in cancerSCF(beta-TrCP1) controls Smad4 protein stability in pancreatic cancer cellsLack of gp130 expression in hepatocytes attenuates tumor progression in the DEN modelRegulation of the TGFbeta signalling pathway by ubiquitin-mediated degradation.A central role for the ring finger protein RNF11 in ubiquitin-mediated proteolysis via interactions with E2s and E3s.Allelic analysis of serous ovarian carcinoma reveals two putative tumor suppressor loci at 18q22-q23 distal to SMAD4, SMAD2, and DCC.The role of TGF-beta in epithelial malignancy and its relevance to the pathogenesis of oral cancer (part II).WW Domain Containing Transcription Regulator regulates human conjunctiva epithelial cell proliferation via inhibiting TGFβ signaling pathway [corrected].To (TGF)beta or not to (TGF)beta: fine-tuning of Smad signaling via post-translational modificationsThe genomics of colorectal cancer: state of the art.Regulation of TGF-beta family signaling by E3 ubiquitin ligases.Regulating the stability of TGFbeta receptors and Smads.Ubiquitination and proteolysis of cancer-derived Smad4 mutants by SCFSkp2Transforming growth factor beta-induced cell cycle arrest of human hematopoietic cells requires p57KIP2 up-regulation.New targeted approaches against the ubiquitin-proteasome system in gastrointestinal malignancies.From tall to short: the role of TGFβ signaling in growth and its disorders.Transforming growth factor-beta and its implication in the malignancy of gliomas.Developmental plasticity, cell fate specification and morphogenesis in the early mouse embryo.SMAD4 and its role in pancreatic cancer.A soluble transforming growth factor-beta (TGF-beta ) type I receptor mimics TGF-beta responses.Chondrodysplasias and TGFβ signaling.Structural determinants of Smad function in TGF-β signaling.
P2860
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P2860
Mutations in the tumor suppressors Smad2 and Smad4 inactivate transforming growth factor beta signaling by targeting Smads to the ubiquitin-proteasome pathway
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
2000年论文
@zh
2000年论文
@zh-cn
name
Mutations in the tumor suppres ...... e ubiquitin-proteasome pathway
@ast
Mutations in the tumor suppres ...... e ubiquitin-proteasome pathway
@en
type
label
Mutations in the tumor suppres ...... e ubiquitin-proteasome pathway
@ast
Mutations in the tumor suppres ...... e ubiquitin-proteasome pathway
@en
prefLabel
Mutations in the tumor suppres ...... e ubiquitin-proteasome pathway
@ast
Mutations in the tumor suppres ...... e ubiquitin-proteasome pathway
@en
P2860
P356
P1476
Mutations in the tumor suppres ...... e ubiquitin-proteasome pathway
@en
P2860
P304
P356
10.1073/PNAS.97.9.4820
P407
P577
2000-04-01T00:00:00Z