Jab1 antagonizes TGF-beta signaling by inducing Smad4 degradation - Wikidata - awgldk - TriplyDB

Jab1 antagonizes TGF-beta signaling by inducing Smad4 degradation

Jab1 antagonizes TGF-beta signaling by inducing Smad4 degradation

http://www.wikidata.org/entity/Q24522552

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Jab1/CSN5, a component of the COP9 signalosome, regulates transforming growth factor beta signaling by binding to Smad7 and promoting its degradation Arkadia amplifies TGF-beta superfamily signalling through degradation of Smad7 S100A7 (psoriasin) expression is associated with aggressive features and alteration of Jab1 in ductal carcinoma in situ of the breast Key role for ubiquitin protein modification in TGFβ signal transduction Multiple functions of Jab1 are required for early embryonic development and growth potential in mice Fank1 interacts with Jab1 and regulates cell apoptosis via the AP-1 pathway.Expression of bone morphogenetic protein 2, 4, and related components of the BMP signaling pathway in the mouse uterus during the estrous cycle Amplification of tumor hypoxic responses by macrophage migration inhibitory factor-dependent hypoxia-inducible factor stabilization.Loss of jab1 in osteochondral progenitor cells severely impairs embryonic limb development in mice.COPing with hypoxia The emerging role of the COP9 signalosome in cancer.Regulation of the human catalytic subunit of telomerase (hTERT).JAB1/CSN5: a new player in cell cycle control and cancer COPS5 (Jab1) protein increases β site processing of amyloid precursor protein and amyloid β peptide generation by stabilizing RanBP9 protein levels.Two major Smad pathways in TGF-beta superfamily signalling.Ubiquitin-dependent regulation of TGFbeta signaling in cancer Developmental expression of p97/VCP (Valosin-containing protein) and Jab1/CSN5 in the rat testis and epididymis.JAB1 determines the response of rheumatoid arthritis synovial fibroblasts to tumor necrosis factor-alpha.Stat3 and CCAAT/enhancer binding protein beta (C/EBP-beta) regulate Jab1/CSN5 expression in mammary carcinoma cells.AMP-activated protein kinase (AMPK) activation inhibits nuclear translocation of Smad4 in mesangial cells and diabetic kidneys.A Transition Zone Showing Highly Discontinuous or Alternating Levels of Stem Cell and Proliferation Markers Characterizes the Development of PTEN-Haploinsufficient Colorectal Cancer.Regulation of the TGFbeta signalling pathway by ubiquitin-mediated degradation.Targeting Jab1/CSN5 in nasopharyngeal carcinoma Essential roles of Jab1 in cell survival, spontaneous DNA damage and DNA repair THE COP9 SIGNALOSOME, A NOVEL, ESSENTIAL REGULATOR OF SKELETAL DEVELOPMENT AND TUMORIGENESIS.The transcriptional co-regulator Jab1 is crucial for chondrocyte differentiation in vivo.Transforming growth factor-beta signaling and ubiquitinators in cancer.To (TGF)beta or not to (TGF)beta: fine-tuning of Smad signaling via post-translational modifications Jab1 mediates protein degradation of the Rad9-Rad1-Hus1 checkpoint complex Quantitative modeling and analysis of the transforming growth factor beta signaling pathway Porcine JAB1 significantly enhances apoptosis induced by staurosporine.Regulating the stability of TGFbeta receptors and Smads.Activin receptor-like kinase5 inhibition suppresses mouse melanoma by ubiquitin degradation of Smad4, thereby derepressing eomesodermin in cytotoxic T lymphocytes.Ubiquitination and proteolysis of cancer-derived Smad4 mutants by SCFSkp2 Postnatal ablation of osteoblast Smad4 enhances proliferative responses to canonical Wnt signaling through interactions with β-catenin.Regulation of TGF-beta signalling by protein phosphatases.Role of Smads in TGFβ signaling.How ubiquitination regulates the TGF-β signalling pathway: new insights and new players: new isoforms of ubiquitin-activating enzymes in the E1-E3 families join the game.Post-translational regulation of TGF-β receptor and Smad signaling.Adaptor regulation of LFA-1 signaling in T lymphocyte migration: Potential druggable targets for immunotherapies?

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Jab1 antagonizes TGF-beta signaling by inducing Smad4 degradation

http://www.wikidata.org/entity/Q24522552

description

2002 nî lūn-bûn

@nan

2002 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2002 թվականի փետրվարին հրատարակված գիտական հոդված

@hy

2002年の論文

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2002年論文

@yue

2002年論文

@zh-hant

2002年論文

@zh-hk

2002年論文

@zh-mo

2002年論文

@zh-tw

2002年论文

@wuu

name

Jab1 antagonizes TGF-beta signaling by inducing Smad4 degradation

@ast

Jab1 antagonizes TGF-beta signaling by inducing Smad4 degradation

@en

Jab1 antagonizes TGF-beta signaling by inducing Smad4 degradation

@en-gb

Jab1 antagonizes TGF-beta signaling by inducing Smad4 degradation

@nl

type

label

Jab1 antagonizes TGF-beta signaling by inducing Smad4 degradation

@ast

Jab1 antagonizes TGF-beta signaling by inducing Smad4 degradation

@en

Jab1 antagonizes TGF-beta signaling by inducing Smad4 degradation

@en-gb

Jab1 antagonizes TGF-beta signaling by inducing Smad4 degradation

@nl

prefLabel

Jab1 antagonizes TGF-beta signaling by inducing Smad4 degradation

@ast

Jab1 antagonizes TGF-beta signaling by inducing Smad4 degradation

@en

Jab1 antagonizes TGF-beta signaling by inducing Smad4 degradation

@en-gb

Jab1 antagonizes TGF-beta signaling by inducing Smad4 degradation

@nl

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Jab1 antagonizes TGF-beta signaling by inducing Smad4 degradation

@en

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Liyu Wu

http://www.w3.org/2001/XMLSchema#string

Mei Wan

http://www.w3.org/2001/XMLSchema#string

Ning Wang

http://www.w3.org/2001/XMLSchema#string

Shuting Bai

http://www.w3.org/2001/XMLSchema#string

Xingming Shi

http://www.w3.org/2001/XMLSchema#string

Xu Cao

http://www.w3.org/2001/XMLSchema#string

Xuesong Cao

http://www.w3.org/2001/XMLSchema#string

Yalei Wu

http://www.w3.org/2001/XMLSchema#string

P2860

A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation

TGF-beta signal transduction

Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling

Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase

Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation

Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation

A new group of conserved coactivators that increase the specificity of AP-1 transcription factors

COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system

Smads bind directly to the Jun family of AP-1 transcription factors

Degradation of the cyclin-dependent-kinase inhibitor p27Kip1 is instigated by Jab1

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171-6

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10.1093/EMBO-REPORTS/KVF024

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2

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2002-02-01T00:00:00Z

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11542326

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11818334

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1083965

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