Comparison of the IKr blockers moxifloxacin, dofetilide and E-4031 in five screening models of pro-arrhythmia reveals lack of specificity of isolated cardiomyocytes
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A novel 3D label-free monitoring system of hES-derived cardiomyocyte clusters: a step forward to in vitro cardiotoxicity testingA Proteomics Approach to Identify New Putative Cardiac Intercalated Disk ProteinsShort-term variability of repolarization is superior to other repolarization parameters in the evaluation of diverse antiarrhythmic interventions in the chronic AV block dog.The inward rectifier current inhibitor PA-6 terminates atrial fibrillation and does not cause ventricular arrhythmias in goat and dog models.Effects of proarrhythmic drugs on relaxation time and beating pattern in rat engineered heart tissue.The high frequency relationship: implications for torsadogenic hERG blockers.The effect of microgrooved culture substrates on calcium cycling of cardiac myocytes derived from human induced pluripotent stem cellsUncertainty and variability in models of the cardiac action potential: Can we build trustworthy models?Electrophysiological and contractile function of cardiomyocytes derived from human embryonic stem cells.Cardiomyocytes from human pluripotent stem cells: From laboratory curiosity to industrial biomedical platform.Current status of drug screening and disease modelling in human pluripotent stem cells.Stem cell models for drug discovery and toxicology studies.Can Human Pluripotent Stem Cell-Derived Cardiomyocytes Advance Understanding of Muscular Dystrophies?Global transcriptional profiling reveals similarities and differences between human stem cell-derived cardiomyocyte clusters and heart tissue.Short-term variability in QT interval and ventricular arrhythmias induced by dofetilide are dependent on high-frequency autonomic oscillations.Calmodulin/CaMKII inhibition improves intercellular communication and impulse propagation in the heart and is antiarrhythmic under conditions when fibrosis is absent.Class III antiarrhythmic drugs amiodarone and dronedarone impair KIR 2.1 backward trafficking.Development of In Vitro Drug-Induced Cardiotoxicity Assay by Using Three-Dimensional Cardiac Tissues Derived from Human Induced Pluripotent Stem Cells.AV-block and conduction slowing prevail over TdP arrhythmias in the methoxamine-sensitized pro-arrhythmic rabbit model.Exploration of human, rat, and rabbit embryonic cardiomyocytes suggests K-channel block as a common teratogenic mechanism.Efficient and specific cardiac IK₁ inhibition by a new pentamidine analogue.Selective late sodium current inhibitor GS-458967 suppresses Torsades de Pointes by mostly affecting perpetuation but not initiation of the arrhythmia.On-chip spatiotemporal electrophysiological analysis of human stem cell derived cardiomyocytes enables quantitative assessment of proarrhythmia in drug development
P2860
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P2860
Comparison of the IKr blockers moxifloxacin, dofetilide and E-4031 in five screening models of pro-arrhythmia reveals lack of specificity of isolated cardiomyocytes
description
2012 nî lūn-bûn
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2012年の論文
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2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
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2012年论文
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2012年论文
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name
Comparison of the IKr blockers ...... ity of isolated cardiomyocytes
@ast
Comparison of the IKr blockers ...... ity of isolated cardiomyocytes
@en
type
label
Comparison of the IKr blockers ...... ity of isolated cardiomyocytes
@ast
Comparison of the IKr blockers ...... ity of isolated cardiomyocytes
@en
prefLabel
Comparison of the IKr blockers ...... ity of isolated cardiomyocytes
@ast
Comparison of the IKr blockers ...... ity of isolated cardiomyocytes
@en
P2093
P2860
P50
P1476
Comparison of the IKr blockers ...... ity of isolated cardiomyocytes
@en
P2093
J D Beekman
M J C Houtman
R Varkevisser
R van der Nagel
T A B van Veen
P2860
P304
P356
10.1111/J.1476-5381.2011.01558.X
P407
P577
2012-01-01T00:00:00Z