Intra- and extracellular amyloid fibrils are formed in cultured pancreatic islets of transgenic mice expressing human islet amyloid polypeptide.
about
Islet amyloid in type 2 diabetes, and the toxic oligomer hypothesisHistorical and Current Concepts of Fibrillogenesis and In vivo Amyloidogenesis: Implications of Amyloid Tissue TargetingAtomic structure of the cross-β spine of islet amyloid polypeptide (amylin)Atomic structures of IAPP (amylin) fusions suggest a mechanism for fibrillation and the role of insulin in the processIdentification of a heparin binding domain in the N-terminal cleavage site of pro-islet amyloid polypeptide. Implications for islet amyloid formation.Islet amyloid deposition limits the viability of human islet grafts but not porcine islet grafts.Endocrine amyloid--a subject of increasing interest for the next century.Amyloidogenicity and cytotoxicity of islet amyloid polypeptide.Glucose- and time-dependence of islet amyloid formation in vitro.Intracellular amyloidogenesis by human islet amyloid polypeptide induces apoptosis in COS-1 cellsAmyloid formation in response to beta cell stress occurs in vitro, but not in vivo, in islets of transgenic mice expressing human islet amyloid polypeptideFeline models of type 2 diabetes mellitus.Human islet amyloid polypeptide transgenic mice: in vivo and ex vivo models for the role of hIAPP in type 2 diabetes mellitus.Small interfering RNA-mediated suppression of proislet amyloid polypeptide expression inhibits islet amyloid formation and enhances survival of human islets in culture.Lessons from two prevalent amyloidoses-what amylin and Aβ have in commonAmyloid deposition in transplanted human pancreatic islets: a conceivable cause of their long-term failure.Non-selective ion channel activity of polymorphic human islet amyloid polypeptide (amylin) double channels.Islet amyloid formation associated with hyperglycemia in transgenic mice with pancreatic beta cell expression of human islet amyloid polypeptide.Amylin and its analogs: a friend or foe for the treatment of Alzheimer's disease?Inhibition of Insulin-Degrading Enzyme Does Not Increase Islet Amyloid Deposition in VitroStructure of alpha-helical membrane-bound human islet amyloid polypeptide and its implications for membrane-mediated misfolding.Glucose regulates islet amyloid polypeptide gene transcription in a PDX1- and calcium-dependent manner.A two-site mechanism for the inhibition of IAPP amyloidogenesis by zinc.Mutation at position -132 in the islet amyloid polypeptide ( IAPP) gene promoter enhances basal transcriptional activity through a new CRE-like binding site.Amylin proprotein processing generates progressively more amyloidogenic peptides that initially sample the helical state.Identifying structural features of fibrillar islet amyloid polypeptide using site-directed spin labeling.apoE4 allele and the natural history of cardiovascular risk factors.Extensive amyloid formation in transplanted microencapsulated mouse and human islets.Islet amyloid polypeptide and insulin gene expression are regulated in parallel by glucose in vivo in rats.Amyloid peptide channels: blockade by zinc and inhibition by Congo red (amyloid channel block).Anin vitromodel of early islet amyloid polypeptide (IAPP) fibrillogenesis using human IAPP-transgenic mouse isletsAmyloid proteins and amyloidosis in domestic animals
P2860
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P2860
Intra- and extracellular amyloid fibrils are formed in cultured pancreatic islets of transgenic mice expressing human islet amyloid polypeptide.
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
1994年论文
@zh
1994年论文
@zh-cn
name
Intra- and extracellular amylo ...... man islet amyloid polypeptide.
@ast
Intra- and extracellular amylo ...... man islet amyloid polypeptide.
@en
type
label
Intra- and extracellular amylo ...... man islet amyloid polypeptide.
@ast
Intra- and extracellular amylo ...... man islet amyloid polypeptide.
@en
prefLabel
Intra- and extracellular amylo ...... man islet amyloid polypeptide.
@ast
Intra- and extracellular amylo ...... man islet amyloid polypeptide.
@en
P2093
P2860
P356
P1476
Intra- and extracellular amylo ...... man islet amyloid polypeptide.
@en
P2093
Hofhuis FM
Höppener JW
Posthuma G
Verbeek JS
de Koning EJ
P2860
P304
P356
10.1073/PNAS.91.18.8467
P407
P577
1994-08-01T00:00:00Z