Intracellular amyloidogenesis by human islet amyloid polypeptide induces apoptosis in COS-1 cells
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Assay development and multivariate scoring for high-content discovery of chemoprotectants of endoplasmic-reticulum-stress-mediated amylin-induced cytotoxicity in pancreatic beta cellsAmyloidogenicity and cytotoxicity of islet amyloid polypeptide.Glucose- and time-dependence of islet amyloid formation in vitro.Concentration-dependent transitions govern the subcellular localization of islet amyloid polypeptideS20G mutant amylin exhibits increased in vitro amyloidogenicity and increased intracellular cytotoxicity compared to wild-type amylin.The Role of 6-Gingerol on Inhibiting Amyloid β Protein-Induced Apoptosis in PC12 CellsFeline models of type 2 diabetes mellitus.β-Cell failure in type 2 diabetes: a case of asking too much of too few?Membrane damage by human islet amyloid polypeptide through fibril growth at the membraneLessons from two prevalent amyloidoses-what amylin and Aβ have in commonRecent insights in islet amyloid polypeptide-induced membrane disruption and its role in beta-cell death in type 2 diabetes mellitusMembrane permeation induced by aggregates of human islet amyloid polypeptidesAtomic structures of fibrillar segments of hIAPP suggest tightly mated β-sheets are important for cytotoxicity.Human IAPP-induced pancreatic β cell toxicity and its regulation by autophagy.Structure of alpha-helical membrane-bound human islet amyloid polypeptide and its implications for membrane-mediated misfolding.Autophagy protects against human islet amyloid polypeptide-associated apoptosisInvolvement of ATP-sensitive potassium (K(ATP)) channels in the loss of beta-cell function induced by human islet amyloid polypeptide.Amylin uncovered: a review on the polypeptide responsible for type II diabetes.Induction of apoptosis by human amylin in RINm5F islet beta-cells is associated with enhanced expression of p53 and p21WAF1/CIP1.Expression, purification and use of recombinant annexin V for the detection of apoptotic cells.Nanoscale tools to selectively destroy cancer cells.Amylin-induced cytotoxicity is associated with activation of caspase-3 and MAP kinases.Amylin gene promoter mutations predispose to Type 2 diabetes in New Zealand Maori.A direct fluorescence-based technique for cellular localization of amylin.Sphingomyelinase dependent apoptosis following treatment of pancreatic beta-cells with amyloid peptides Abeta(1-42) or IAPP.Development of proteolytically stable N-methylated peptide inhibitors of aggregation of the amylin peptide implicated in type 2 diabetes.Copper-mediated formation of hydrogen peroxide from the amylin peptide: A novel mechanism for degeneration of islet cells in type-2 diabetes mellitus?Characterisation of the Structure and Oligomerisation of Islet Amyloid Polypeptides (IAPP): A Review of Molecular Dynamics Simulation Studies
P2860
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P2860
Intracellular amyloidogenesis by human islet amyloid polypeptide induces apoptosis in COS-1 cells
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
1999年论文
@zh
1999年论文
@zh-cn
name
Intracellular amyloidogenesis ...... duces apoptosis in COS-1 cells
@ast
Intracellular amyloidogenesis ...... duces apoptosis in COS-1 cells
@en
type
label
Intracellular amyloidogenesis ...... duces apoptosis in COS-1 cells
@ast
Intracellular amyloidogenesis ...... duces apoptosis in COS-1 cells
@en
prefLabel
Intracellular amyloidogenesis ...... duces apoptosis in COS-1 cells
@ast
Intracellular amyloidogenesis ...... duces apoptosis in COS-1 cells
@en
P2860
P1476
Intracellular amyloidogenesis ...... duces apoptosis in COS-1 cells
@en
P2093
H J Hiddinga
N L Eberhardt
P2860
P304
P356
10.1016/S0002-9440(10)65360-6
P407
P577
1999-04-01T00:00:00Z