Defective DNA repair and increased genomic instability in Cernunnos-XLF-deficient murine ES cells.
about
ATM damage response and XLF repair factor are functionally redundant in joining DNA breaksFunctional redundancy between the XLF and DNA-PKcs DNA repair factors in V(D)J recombination and nonhomologous DNA end joiningRobust chromosomal DNA repair via alternative end-joining in the absence of X-ray repair cross-complementing protein 1 (XRCC1)A human XRCC4-XLF complex bridges DNAXRCC4's interaction with XLF is required for coding (but not signal) end joiningPrimary immunodeficiency diseases: an update from the International Union of Immunological Societies Primary Immunodeficiency Diseases Classification CommitteeLymphocyte-specific compensation for XLF/cernunnos end-joining functions in V(D)J recombinationThe linear no-threshold relationship is inconsistent with radiation biologic and experimental dataThe response to and repair of RAG-mediated DNA double-strand breaksATM limits incorrect end utilization during non-homologous end joining of multiple chromosome breaksEvolutionary genomics of human intellectual disabilityThe relative efficiency of homology-directed repair has distinct effects on proper anaphase chromosome separation.Two-Stage Synapsis of DNA Ends during Non-homologous End Joining.Impaired replication stress response in cells from immunodeficiency patients carrying Cernunnos/XLF mutations.Bcl2 negatively regulates DNA double-strand-break repair through a nonhomologous end-joining pathwayWerner syndrome protein positively regulates XRCC4-like factor transcriptionActivating WASP mutations associated with X-linked neutropenia result in enhanced actin polymerization, altered cytoskeletal responses, and genomic instability in lymphocytes.Hematopoietic stem cell dysfunction underlies the progressive lymphocytopenia in XLF/Cernunnos deficiencyCernunnos influences human immunoglobulin class switch recombination and may be associated with B cell lymphomagenesisMouse Rad9b is essential for embryonic development and promotes resistance to DNA damageXRCC4 and XLF form long helical protein filaments suitable for DNA end protection and alignment to facilitate DNA double strand break repair.Cooperative assembly of a protein-DNA filament for nonhomologous end joiningAtaxia telangiectasia-mutated protein and DNA-dependent protein kinase have complementary V(D)J recombination functions.End-processing during non-homologous end-joining: a role for exonuclease 1Interplay between Cernunnos-XLF and nonhomologous end-joining proteins at DNA ends in the cell.Defining a genotoxic profile with mouse embryonic stem cellsUnique and redundant functions of ATM and DNA-PKcs during V(D)J recombinationInduced pluripotent stem cells are sensitive to DNA damage.Crystallization and preliminary X-ray diffraction analysis of the human XRCC4-XLF complex.Differential phosphorylation of DNA-PKcs regulates the interplay between end-processing and end-ligation during nonhomologous end-joining.Functional redundancy between repair factor XLF and damage response mediator 53BP1 in V(D)J recombination and DNA repair.Overlapping functions between XLF repair protein and 53BP1 DNA damage response factor in end joining and lymphocyte developmentXRCC4/XLF Interaction Is Variably Required for DNA Repair and Is Not Required for Ligase IV StimulationDNA-damage repair; the good, the bad, and the ugly.c-Myc suppression of DNA double-strand break repair.RAG2 and XLF/Cernunnos interplay reveals a novel role for the RAG complex in DNA repairV(D)J and immunoglobulin class switch recombinations: a paradigm to study the regulation of DNA end-joining.DNA strand breaks, neurodegeneration and aging in the brain.Mouse models of DNA double-strand break repair and neurological diseaseRole of the yeast DNA repair protein Nej1 in end processing during the repair of DNA double strand breaks by non-homologous end joining
P2860
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P2860
Defective DNA repair and increased genomic instability in Cernunnos-XLF-deficient murine ES cells.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Defective DNA repair and incre ...... XLF-deficient murine ES cells.
@ast
Defective DNA repair and incre ...... XLF-deficient murine ES cells.
@en
type
label
Defective DNA repair and incre ...... XLF-deficient murine ES cells.
@ast
Defective DNA repair and incre ...... XLF-deficient murine ES cells.
@en
prefLabel
Defective DNA repair and incre ...... XLF-deficient murine ES cells.
@ast
Defective DNA repair and incre ...... XLF-deficient murine ES cells.
@en
P2093
P2860
P356
P1476
Defective DNA repair and incre ...... XLF-deficient murine ES cells.
@en
P2093
Frederick W Alt
Hwei-Ling Cheng
James W Brush
P2860
P304
P356
10.1073/PNAS.0611734104
P407
P577
2007-03-07T00:00:00Z