JNK-mediated induction of cyclooxygenase 2 is required for neurodegeneration in a mouse model of Parkinson's disease. - Wikidata - awgldk - TriplyDB

JNK-mediated induction of cyclooxygenase 2 is required for neurodegeneration in a mouse model of Parkinson's disease.

JNK-mediated induction of cyclooxygenase 2 is required for neurodegeneration in a mouse model of Parkinson's disease.

http://www.wikidata.org/entity/Q35736273

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MKK6 binds and regulates expression of Parkinson's disease-related protein LRRK2 Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stress Selective COX-2 inhibition prevents progressive dopamine neuron degeneration in a rat model of Parkinson's disease Chronic Inflammation Links Cancer and Parkinson's Disease Chronic Stress and Glucocorticoids: From Neuronal Plasticity to Neurodegeneration Neuronal response in Alzheimer's and Parkinson's disease: the effect of toxic proteins on intracellular pathways Regulation of Bim in Health and Disease JNK signalling in cancer: in need of new, smarter therapeutic targets Structure-Activity Relationships and X-ray Structures Describing the Selectivity of Aminopyrazole Inhibitors for c-Jun N-terminal Kinase 3 (JNK3) over p38 Synthesis, Biological Evaluation, X-ray Structure, and Pharmacokinetics of Aminopyrimidine c-jun-N-terminal Kinase (JNK) Inhibitors Discovery of Potent and Selective Covalent Inhibitors of JNK Protein Kinases and Parkinson's Disease Resveratrol potently reduces prostaglandin E2 production and free radical formation in lipopolysaccharide-activated primary rat microglia Stressor-like effects of c-Jun N-terminal kinase (JNK) inhibition Identification of licopyranocoumarin and glycyrurol from herbal medicines as neuroprotective compounds for Parkinson's disease Bag1-L is a phosphorylation-dependent coactivator of c-Jun during neuronal apoptosis.JNK3 mediates paraquat- and rotenone-induced dopaminergic neuron death.The c-jun kinase/stress-activated pathway: regulation, function and role in human disease.Activation of p38MAPK contributes to expanded polyglutamine-induced cytotoxicity.Parkinson's disease-implicated kinases in the brain; insights into disease pathogenesis.Increased mitochondrial calcium sensitivity and abnormal expression of innate immunity genes precede dopaminergic defects in Pink1-deficient mice.Loss of ATF2 function leads to cranial motoneuron degeneration during embryonic mouse development Parkin negatively regulates JNK pathway in the dopaminergic neurons of Drosophila.Defining a role for hemoglobin in Parkinson's disease Role of microglia adenosine A(2A) receptors in retinal and brain neurodegenerative diseases.Glial cell line-derived neurotrophic factor protects midbrain dopaminergic neurons against lipopolysaccharide neurotoxicity.Apoptosis signal-regulating kinase 1 mediates MPTP toxicity and regulates glial activation.Activation of c-Jun N-terminal kinase (JNK) during mitosis in retinal progenitor cells.Endoplasmic reticulum stress (ER-stress) by 2-deoxy-D-glucose (2DG) reduces cyclooxygenase-2 (COX-2) expression and N-glycosylation and induces a loss of COX-2 activity via a Src kinase-dependent pathway in rabbit articular chondrocytes.Exploring Braak's Hypothesis of Parkinson's Disease.Design and synthesis of highly potent and isoform selective JNK3 inhibitors: SAR studies on aminopyrazole derivatives.Intracellular signalling pathways in dopamine cell death and axonal degeneration.Expression of mutant alpha-synuclein modulates microglial phenotype in vitro Structural basis and biological consequences for JNK2/3 isoform selective aminopyrazoles.JNK Inhibition Protects Dopamine Neurons and Provides Behavioral Improvement in a Rat 6-hydroxydopamine Model of Parkinson's Disease.DLK induces developmental neuronal degeneration via selective regulation of proapoptotic JNK activity JNK isoforms differentially regulate neurite growth and regeneration in dopaminergic neurons in vitro.Hypothalamic inflammation: a double-edged sword to nutritional diseases.Synaptic and extrasynaptic NMDA receptors differentially modulate neuronal cyclooxygenase-2 function, lipid peroxidation, and neuroprotection.Increased levels of cerebrospinal fluid JNK3 associated with amyloid pathology: links to cognitive decline.

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P2860

JNK-mediated induction of cyclooxygenase 2 is required for neurodegeneration in a mouse model of Parkinson's disease.

http://www.wikidata.org/entity/Q35736273

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Proceedings of the National Academy of Sciences of the United States of America

P1476

JNK-mediated induction of cycl ...... model of Parkinson's disease.

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P2093

Etienne C Hirsch

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Pasko Rakic

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Peter Teismann

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Richard A Flavell

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Roger J Davis

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P2860

Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation

Signal transduction by the JNK group of MAP kinases

Mechanisms of excitotoxicity in neurologic diseases

Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene

Parkinson's disease: mechanisms and models

Cyclooxygenases: structural, cellular, and molecular biology

Fluid shear stress-induced cyclooxygenase-2 expression is mediated by C/EBP beta, cAMP-response element-binding protein, and AP-1 in osteoblastic MC3T3-E1 cells.

Etiology and pathogenesis of Parkinson's disease.

Gene transfer of the JNK interacting protein-1 protects dopaminergic neurons in the MPTP model of Parkinson's disease.

The role of glial cells in Parkinson's disease.

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Stéphane Hunot

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8936036

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Parkinson's disease

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327205

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