A genetic approach for identifying critical residues in the fingers and palm subdomains of HIV-1 reverse transcriptase.
about
HotSpot Wizard: a web server for identification of hot spots in protein engineering.Computational approaches to study the effects of small genomic variations.Purifying selection masks the mutational flexibility of HIV-1 reverse transcriptase.High sequence conservation of human immunodeficiency virus type 1 reverse transcriptase under drug pressure despite the continuous appearance of mutations.The exchangeability of amino acids in proteinsAnalysis of mutations at positions 115 and 116 in the dNTP binding site of HIV-1 reverse transcriptase.The L80I substitution in the reverse transcriptase domain of the hepatitis B virus polymerase is associated with lamivudine resistance and enhanced viral replication in vitroMutations in human immunodeficiency virus type 1 reverse transcriptase that make it sensitive to degradation by the viral protease in virions are selected against in patients.Mutations in HIV-1 reverse transcriptase cause misfolding and miscleavage by the viral protease.Mutations in the thumb allow human immunodeficiency virus type 1 reverse transcriptase to be cleaved by protease in virions.Variation of human immunodeficiency virus type-1 reverse transcriptase within the simian immunodeficiency virus genome of RT-SHIV.Second-site reversion of a human immunodeficiency virus type 1 reverse transcriptase mutant that restores enzyme function and replication capacity.Amino acid substitutions at position 190 of human immunodeficiency virus type 1 reverse transcriptase increase susceptibility to delavirdine and impair virus replication.Six Highly Conserved Targets of RNAi Revealed in HIV-1-Infected Patients from Russia Are Also Present in Many HIV-1 Strains Worldwide.Physicochemical constraint violation by missense substitutions mediates impairment of protein function and disease severity.Nucleotide specificity of HIV-1 reverse transcriptases with amino acid substitutions affecting Ala-114.Insights into the role of an active site aspartate in Ty1 reverse transcriptase polymerization.Four-body scoring function for mutagenesis.
P2860
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P2860
A genetic approach for identifying critical residues in the fingers and palm subdomains of HIV-1 reverse transcriptase.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
1998年论文
@zh
1998年论文
@zh-cn
name
A genetic approach for identif ...... f HIV-1 reverse transcriptase.
@ast
A genetic approach for identif ...... f HIV-1 reverse transcriptase.
@en
type
label
A genetic approach for identif ...... f HIV-1 reverse transcriptase.
@ast
A genetic approach for identif ...... f HIV-1 reverse transcriptase.
@en
prefLabel
A genetic approach for identif ...... f HIV-1 reverse transcriptase.
@ast
A genetic approach for identif ...... f HIV-1 reverse transcriptase.
@en
P2093
P2860
P356
P1476
A genetic approach for identif ...... f HIV-1 reverse transcriptase.
@en
P2093
C A Hutchison
G J Pielak
J A Wrobel
J D Merker
M J Conrad
R Swanstrom
P2860
P304
P356
10.1073/PNAS.95.2.638
P407
P577
1998-01-01T00:00:00Z