Second-site reversion of a human immunodeficiency virus type 1 reverse transcriptase mutant that restores enzyme function and replication capacity.
about
Evidence of a role for the Q151L mutation and the viral background in development of multiple dideoxynucleoside-resistant human immunodeficiency virus type 1Positive and negative aspects of the human immunodeficiency virus protease: development of inhibitors versus its role in AIDS pathogenesisA Leu to Ile but not Leu to Val change at HIV-1 reverse transcriptase codon 74 in the background of K65R mutation leads to an increased processivity of K65R+L74I enzyme and a replication competent virus.Compensation by the E138K mutation in HIV-1 reverse transcriptase for deficits in viral replication capacity and enzyme processivity associated with the M184I/V mutations.HIV-1 protease dimer interface mutations that compensate for viral reverse transcriptase instability in infectious virions.Comparative analysis of in vitro processivity of HIV-1 reverse transcriptases containing mutations 65R, 74V, 184V and 65R+74V.Mutation rates and intrinsic fidelity of retroviral reverse transcriptases.dNTP versus NTP discrimination by phenylalanine 451 in duck hepatitis B virus P protein indicates a common structure of the dNTP-binding pocket with other reverse transcriptases.A mutation in the primer grip region of HIV-1 reverse transcriptase that confers reduced fidelity of DNA synthesisSystematic study of the genetic response of a variable virus to the introduction of deleterious mutations in a functional capsid region.The hepatitis B virus polymerase mutation rtV173L is selected during lamivudine therapy and enhances viral replication in vitro.Identification of a novel resistance (E40F) and compensatory (K43E) substitution in HIV-1 reverse transcriptase.Deterministic, compensatory mutational events in the capsid of foot-and-mouth disease virus in response to the introduction of mutations found in viruses from persistent infections.Increased G-->A transition frequencies displayed by primer grip mutants of human immunodeficiency virus type 1 reverse transcriptaseHypersusceptibility to substrate analogs conferred by mutations in human immunodeficiency virus type 1 reverse transcriptase.
P2860
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P2860
Second-site reversion of a human immunodeficiency virus type 1 reverse transcriptase mutant that restores enzyme function and replication capacity.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
1999年论文
@zh
1999年论文
@zh-cn
name
Second-site reversion of a hum ...... tion and replication capacity.
@en
Second-site reversion of a hum ...... tion and replication capacity.
@nl
type
label
Second-site reversion of a hum ...... tion and replication capacity.
@en
Second-site reversion of a hum ...... tion and replication capacity.
@nl
prefLabel
Second-site reversion of a hum ...... tion and replication capacity.
@en
Second-site reversion of a hum ...... tion and replication capacity.
@nl
P2093
P2860
P1433
P1476
Second-site reversion of a hum ...... ction and replication capacity
@en
P2093
López-Galíndez C
Menéndez-Arias L
Olivares I
Sánchez-Merino V
P2860
P304
P407
P577
1999-08-01T00:00:00Z