Discovery of a Novel Class of Negative Allosteric Modulator of the Dopamine D2 Receptor Through Fragmentation of a Bitopic Ligand.

Discovery of a Novel Class of Negative Allosteric Modulator of the Dopamine D2 Receptor Through Fragmentation of a Bitopic Ligand.

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http://www.wikidata.org/entity/Q35741435
The First Negative Allosteric Modulator for Dopamine D2 and D3 Receptors, SB269652 May Lead to a New Generation of Antipsychotic DrugsFunctional Characterization of a Novel Series of Biased Signaling Dopamine D3 Receptor Agonists.Multivalent approaches and beyond: novel tools for the investigation of dopamine D2 receptor pharmacology.Targeting multiple opioid receptors - improved analgesics with reduced side effects?Allosteric Modulation of GPCRs: New Insights and Potential Utility for Treatment of Schizophrenia and Other CNS Disorders.Highly Selective Dopamine D3 Receptor (D3R) Antagonists and Partial Agonists Based on Eticlopride and the D3R Crystal Structure: New Leads for Opioid Dependence Treatment.The E2.65A mutation disrupts dynamic binding poses of SB269652 at the dopamine D2 and D3 receptors.Synthesis and Pharmacological Characterization of Novel trans-Cyclopropylmethyl-Linked Bivalent Ligands That Exhibit Selectivity and Allosteric Pharmacology at the Dopamine D3 Receptor (D3R).Design, synthesis, in vitro antiproliferative activity and apoptosis-inducing studies of 1-(3',4',5'-trimethoxyphenyl)-3-(2'-alkoxycarbonylindolyl)-2-propen-1-one derivatives obtained by a molecular hybridisation approach
P2860

Discovery of a Novel Class of Negative Allosteric Modulator of the Dopamine D2 Receptor Through Fragmentation of a Bitopic Ligand.

Item
http://www.wikidata.org/entity/Q35741435
description
2015 nî lūn-bûn
@nan
2015年の論文
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2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
Discovery of a Novel Class of ...... mentation of a Bitopic Ligand.
@ast
Discovery of a Novel Class of ...... mentation of a Bitopic Ligand.
@en
type
label
Discovery of a Novel Class of ...... mentation of a Bitopic Ligand.
@ast
Discovery of a Novel Class of ...... mentation of a Bitopic Ligand.
@en
prefLabel
Discovery of a Novel Class of ...... mentation of a Bitopic Ligand.
@ast
Discovery of a Novel Class of ...... mentation of a Bitopic Ligand.
@en
P1433
P1476
P2093
P304
P31
P356
P407
P433
P478
P50
P577
P698
P356
P1433
P1476
Discovery of a Novel Class of ...... mentation of a Bitopic Ligand.
@en
P2093
P304
P31
P356
10.1021/ACS.JMEDCHEM.5B00585
P407
P433
P478
P50
P577
P698