Cathepsin k is a critical protease in synovial fibroblast-mediated collagen degradation.
about
Drugs in development: bisphosphonates and metalloproteinase inhibitorsSerum cathepsin K levels of patients with longstanding rheumatoid arthritis: correlation with radiological destruction.Local expression of matrix metalloproteinases, cathepsins, and their inhibitors during the development of murine antigen-induced arthritisEffects of disease-modifying anti-rheumatic drugs (DMARDs) on the activities of rheumatoid arthritis-associated cathepsins K and SStructure-Activity Analysis of Cathepsin K/Chondroitin 4-Sulfate InteractionsBiochemical markers of ongoing joint damage in rheumatoid arthritis--current and future applications, limitations and opportunities.A soft coral-derived compound, 11-epi-sinulariolide acetate suppresses inflammatory response and bone destruction in adjuvant-induced arthritisCathepsin L plays an important role in the lysosomal degradation of L-lactate dehydrogenaseCathepsin K inhibitors for osteoporosis and potential off-target effectsNovel advances in the treatment of osteoporosis.Periploca forrestii saponin ameliorates CIA via suppressing proinflammatory cytokines and nuclear factor kappa-B pathways.Pathogenesis of bone lesions in rheumatoid arthritis.Cathepsin K is present in invasive oral tongue squamous cell carcinoma in vivo and in vitroThe effect of cathepsin K deficiency on airway development and TGF-β1 degradation.Pivotal role of cathepsin K in lung fibrosis.Ultraviolet A-induced cathepsin K expression is mediated via MAPK/AP-1 pathway in human dermal fibroblasts.How does the pathophysiological context influence delivery of bone growth factors?Cartilage destruction mediated by synovial fibroblasts does not depend on proliferation in rheumatoid arthritisNew treatment modalities in osteoporosis.Potential role of odanacatib in the treatment of osteoporosis.Drug delivery strategies for cathepsin inhibitors in joint diseases.Proteinases in the joint: clinical relevance of proteinases in joint destructionQuantitative proteomics reveals altered expression of extracellular matrix related proteins of human primary dermal fibroblasts in response to sulfated hyaluronan and collagen applied as artificial extracellular matrix.Curcumin improves bone microarchitecture in glucocorticoid-induced secondary osteoporosis mice through the activation of microRNA-365 via regulating MMP-9.Joint Degradation in a Monkey Model of Collagen-Induced Arthritis: Role of Cathepsin K Based on Biochemical Markers and Histological Evaluation.Therapeutic inhibition of cathepsin K-reducing bone resorption while maintaining bone formation.Odanacatib in postmenopausal women with low bone mineral density: a review of current clinical evidence.Proteinases involved in matrix turnover during cartilage and bone breakdown.Regulation of bone by the adaptive immune system in arthritis.Cysteine cathepsins and their potential in clinical therapy and biomarker discovery.The role of osteoclasts in bone tissue engineering.The Roles of Lysosomes in Inflammation and Autoimmune Diseases.Novel targets for the prevention of osteoporosis - lessons learned from studies of metabolic bone disorders.Cathepsin K osteoporosis trials, pycnodysostosis and mouse deficiency models: Commonalities and differences.Protein tyrosine phosphatase expression profile of rheumatoid arthritis fibroblast-like synoviocytes: a novel role of SH2 domain-containing phosphatase 2 as a modulator of invasion and survival.Single Cell Chemical Cytometry of Akt Activity in Rheumatoid Arthritis and Normal Fibroblast-like Synoviocytes in Response to Tumor Necrosis Factor α.A novel approach to inhibit bone resorption: exosite inhibitors against cathepsin KCysteine cathepsin activity regulation by glycosaminoglycans.Up regulation of cathepsin K expression in articular chondrocytes in a transgenic mouse model for osteoarthritisRegulation of chemerin chemoattractant and antibacterial activity by human cysteine cathepsins.
P2860
Q24795847-8E716D8C-B784-4AFB-B943-92032F9BCB5EQ24799065-FE9A990C-1FF8-46A8-832B-679FC7208E7CQ24799214-A9A41DED-E4FF-4BA6-BE00-D6732D872D67Q27643987-DDA0F9E7-84F7-4031-94A2-E6FABEACC120Q27666421-DAA29820-7327-4F8A-94D8-98B43436336CQ27687777-3A95F235-6FEC-4B61-B96A-34746F51AF83Q28487935-F5B35DCD-74FE-464B-9B89-A0E73013A57EQ28570792-049D26F1-2E48-443D-9D24-B50DF189E713Q29042565-F5E128BD-4053-46E4-AE26-356631D744A5Q30248319-F84DDEB8-0415-42DE-AF81-83C39F4AA4DFQ33626416-EE72BFF9-56E6-4940-B3E7-19E094758015Q34637331-D0CE30A4-5E16-4F4E-A7D0-2A9F88310A4AQ34948094-9ACB77CE-E9D5-4F57-8ACE-7382EE29ACDDQ35073995-51A9A6B6-4D53-4D89-9BD6-F9257BED5A40Q35098381-1D8692BE-68AD-4CFB-8F06-F73101009617Q35210637-B9761D2F-A988-4432-BE17-1BB2C5AB7892Q35463054-5C5BDD87-2A9F-46AC-848D-078B437F3E05Q35749068-1E668D33-BC54-4553-B3E0-DDC61E97C3A8Q35754801-4E89C0B0-3CA2-423C-8682-47C639C4F39AQ36136239-5ED37AC5-37E0-4450-94B9-EDBAE33E9E30Q36316921-C01FFC74-1216-4AC1-B102-CDF32A2EBC9CQ36401848-1C165780-FA12-49C2-8D11-7362EDA92519Q36422920-4FC7C681-DE91-4812-BA05-0F3721D6A64DQ36511687-52B41CF0-C62F-43D7-BEEE-D3F7570C1430Q36582672-AA0A2657-15E0-42DC-B351-B9094F16C112Q37056336-23EAC4A7-D08C-4A72-92B9-338AFE50EBF4Q37058788-2A460DB8-B1B3-4A1E-810D-329E357425F8Q37633409-1D9A6D7A-8E40-4882-9BCF-3E0736C20142Q37884121-208E4B2F-7D03-44A9-92DB-E0CCEFCBFF3DQ38182521-26B68B42-0A2A-482C-A2C2-19D522AF39E9Q38183343-65337D87-9B8A-42F8-ADB6-9E0C29C070B7Q38235294-874A93D6-C677-4651-B833-A9FD5BA2BD81Q38470745-DB533D8A-6BA0-4497-A3FD-6C6262CC2C11Q38784335-24A68690-5937-4A21-AE36-5DC5C58FF351Q39207570-FC9A2DB0-FE1A-426C-83EF-9F6B3A7CCB76Q39621544-044E1D92-228E-43F2-AF25-00C5EB76D480Q41771681-36496F2C-DAE0-48B9-9216-0145E9DFDD1AQ41852264-E1E58359-8978-4BF6-8DD2-7BEB6235D193Q42099733-F85CFCF7-40F6-4826-BAFF-E798E5B4092BQ42834477-47578252-AD9D-4459-B21F-5ACEEA659919
P2860
Cathepsin k is a critical protease in synovial fibroblast-mediated collagen degradation.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
2001年论文
@zh
2001年论文
@zh-cn
name
Cathepsin k is a critical protease in synovial fibroblast-mediated collagen degradation.
@ast
Cathepsin k is a critical protease in synovial fibroblast-mediated collagen degradation.
@en
type
label
Cathepsin k is a critical protease in synovial fibroblast-mediated collagen degradation.
@ast
Cathepsin k is a critical protease in synovial fibroblast-mediated collagen degradation.
@en
prefLabel
Cathepsin k is a critical protease in synovial fibroblast-mediated collagen degradation.
@ast
Cathepsin k is a critical protease in synovial fibroblast-mediated collagen degradation.
@en
P2093
P2860
P1476
Cathepsin k is a critical protease in synovial fibroblast-mediated collagen degradation.
@en
P2093
R E Gordon
P2860
P304
P356
10.1016/S0002-9440(10)63068-4
P407
P577
2001-12-01T00:00:00Z